Impact of low skeletal muscle mass index and perioperative blood transfusion on the prognosis for HCC following curative resection
Abstract Background This study aimed to assess the prognostic factors including low skeletal muscle mass index (SMI) and perioperative blood transfusion for patients with hepatocellular carcinoma (HCC) following curative surgery. Methods This study included 139 patients with HCC who underwent hepate...
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | BMC Gastroenterology |
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| Online Access: | http://link.springer.com/article/10.1186/s12876-020-01472-z |
| _version_ | 1818305266596184064 |
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| author | Tomoaki Bekki Tomoyuki Abe Hironobu Amano Minoru Hattori Tsuyoshi Kobayashi Masahiro Nakahara Hideki Ohdan Toshio Noriyuki |
| author_facet | Tomoaki Bekki Tomoyuki Abe Hironobu Amano Minoru Hattori Tsuyoshi Kobayashi Masahiro Nakahara Hideki Ohdan Toshio Noriyuki |
| author_sort | Tomoaki Bekki |
| collection | DOAJ |
| description | Abstract Background This study aimed to assess the prognostic factors including low skeletal muscle mass index (SMI) and perioperative blood transfusion for patients with hepatocellular carcinoma (HCC) following curative surgery. Methods This study included 139 patients with HCC who underwent hepatectomy between 2005 and 2016. Univariate and multivariate analyses were performed to identify variables associated with overall survival (OS) and recurrence-free survival (RFS). Results Low SMI was significantly related with poor OS, while blood transfusion had a strong impact on RFS. The male ratio and body mass index in the low SMI group were significantly higher than those in the high SMI group. There were no significant differences in age, virus etiology, laboratory data, liver function, tumor makers, and operative variables between the groups. Tumor factors such as tumor diameter, tumor number, poor differentiation, and intrahepatic metastasis (IM) did not significantly differ between the two groups. Operation time, intraoperative blood loss volume, and recurrence ratio were significantly higher in the blood transfusion group than in the non-transfusion group. IM was associated with poor OS and RFS. Conclusions Low SMI and blood transfusion were independently related with long-term prognosis in patients with HCC following curative surgery. |
| first_indexed | 2024-12-13T06:23:52Z |
| format | Article |
| id | doaj.art-ea04f14896d742e9a407afcaf11db749 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-13T06:23:52Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-ea04f14896d742e9a407afcaf11db7492022-12-21T23:56:47ZengBMCBMC Gastroenterology1471-230X2020-10-0120111110.1186/s12876-020-01472-zImpact of low skeletal muscle mass index and perioperative blood transfusion on the prognosis for HCC following curative resectionTomoaki Bekki0Tomoyuki Abe1Hironobu Amano2Minoru Hattori3Tsuyoshi Kobayashi4Masahiro Nakahara5Hideki Ohdan6Toshio Noriyuki7Department of Surgery, Onomichi General HospitalDepartment of Surgery, Onomichi General HospitalDepartment of Surgery, Onomichi General HospitalAdvanced Medical Skills Training Center, Institute of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Surgery, Onomichi General HospitalDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Surgery, Onomichi General HospitalAbstract Background This study aimed to assess the prognostic factors including low skeletal muscle mass index (SMI) and perioperative blood transfusion for patients with hepatocellular carcinoma (HCC) following curative surgery. Methods This study included 139 patients with HCC who underwent hepatectomy between 2005 and 2016. Univariate and multivariate analyses were performed to identify variables associated with overall survival (OS) and recurrence-free survival (RFS). Results Low SMI was significantly related with poor OS, while blood transfusion had a strong impact on RFS. The male ratio and body mass index in the low SMI group were significantly higher than those in the high SMI group. There were no significant differences in age, virus etiology, laboratory data, liver function, tumor makers, and operative variables between the groups. Tumor factors such as tumor diameter, tumor number, poor differentiation, and intrahepatic metastasis (IM) did not significantly differ between the two groups. Operation time, intraoperative blood loss volume, and recurrence ratio were significantly higher in the blood transfusion group than in the non-transfusion group. IM was associated with poor OS and RFS. Conclusions Low SMI and blood transfusion were independently related with long-term prognosis in patients with HCC following curative surgery.http://link.springer.com/article/10.1186/s12876-020-01472-zBlood transfusionHepatocellular carcinomaLow SMI |
| spellingShingle | Tomoaki Bekki Tomoyuki Abe Hironobu Amano Minoru Hattori Tsuyoshi Kobayashi Masahiro Nakahara Hideki Ohdan Toshio Noriyuki Impact of low skeletal muscle mass index and perioperative blood transfusion on the prognosis for HCC following curative resection BMC Gastroenterology Blood transfusion Hepatocellular carcinoma Low SMI |
| title | Impact of low skeletal muscle mass index and perioperative blood transfusion on the prognosis for HCC following curative resection |
| title_full | Impact of low skeletal muscle mass index and perioperative blood transfusion on the prognosis for HCC following curative resection |
| title_fullStr | Impact of low skeletal muscle mass index and perioperative blood transfusion on the prognosis for HCC following curative resection |
| title_full_unstemmed | Impact of low skeletal muscle mass index and perioperative blood transfusion on the prognosis for HCC following curative resection |
| title_short | Impact of low skeletal muscle mass index and perioperative blood transfusion on the prognosis for HCC following curative resection |
| title_sort | impact of low skeletal muscle mass index and perioperative blood transfusion on the prognosis for hcc following curative resection |
| topic | Blood transfusion Hepatocellular carcinoma Low SMI |
| url | http://link.springer.com/article/10.1186/s12876-020-01472-z |
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