Mechanisms of increased bioavailability through amorphous solid dispersions: a review
Amorphous solid dispersions (ASDs) can increase the oral bioavailability of poorly soluble drugs. However, their use in drug development is comparably rare due to a lack of basic understanding of mechanisms governing drug liberation and absorption in vivo. Furthermore, the lack of a unified nomencla...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10717544.2019.1704940 |
| _version_ | 1818656878000865280 |
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| author | Andreas Schittny Jörg Huwyler Maxim Puchkov |
| author_facet | Andreas Schittny Jörg Huwyler Maxim Puchkov |
| author_sort | Andreas Schittny |
| collection | DOAJ |
| description | Amorphous solid dispersions (ASDs) can increase the oral bioavailability of poorly soluble drugs. However, their use in drug development is comparably rare due to a lack of basic understanding of mechanisms governing drug liberation and absorption in vivo. Furthermore, the lack of a unified nomenclature hampers the interpretation and classification of research data. In this review, we therefore summarize and conceptualize mechanisms covering the dissolution of ASDs, formation of supersaturated ASD solutions, factors responsible for solution stabilization, drug uptake from ASD solutions, and drug distribution within these complex systems as well as effects of excipients. Furthermore, we discuss the importance of these findings on the development of ASDs. This improved overall understanding of these mechanisms will facilitate a rational ASD formulation development and will serve as a basis for further mechanistic research on drug delivery by ASDs. |
| first_indexed | 2024-12-17T03:32:34Z |
| format | Article |
| id | doaj.art-ea0541b982f44eacbc356a06b8193afc |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-12-17T03:32:34Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-ea0541b982f44eacbc356a06b8193afc2022-12-21T22:05:14ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642020-01-0127111012710.1080/10717544.2019.17049401704940Mechanisms of increased bioavailability through amorphous solid dispersions: a reviewAndreas Schittny0Jörg Huwyler1Maxim Puchkov2Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of BaselDepartment of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of BaselDepartment of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of BaselAmorphous solid dispersions (ASDs) can increase the oral bioavailability of poorly soluble drugs. However, their use in drug development is comparably rare due to a lack of basic understanding of mechanisms governing drug liberation and absorption in vivo. Furthermore, the lack of a unified nomenclature hampers the interpretation and classification of research data. In this review, we therefore summarize and conceptualize mechanisms covering the dissolution of ASDs, formation of supersaturated ASD solutions, factors responsible for solution stabilization, drug uptake from ASD solutions, and drug distribution within these complex systems as well as effects of excipients. Furthermore, we discuss the importance of these findings on the development of ASDs. This improved overall understanding of these mechanisms will facilitate a rational ASD formulation development and will serve as a basis for further mechanistic research on drug delivery by ASDs.http://dx.doi.org/10.1080/10717544.2019.1704940amorphous solid dispersionexcipientspoorly water-soluble drugsoral bioavailabilitydissolutiondrug absorption |
| spellingShingle | Andreas Schittny Jörg Huwyler Maxim Puchkov Mechanisms of increased bioavailability through amorphous solid dispersions: a review Drug Delivery amorphous solid dispersion excipients poorly water-soluble drugs oral bioavailability dissolution drug absorption |
| title | Mechanisms of increased bioavailability through amorphous solid dispersions: a review |
| title_full | Mechanisms of increased bioavailability through amorphous solid dispersions: a review |
| title_fullStr | Mechanisms of increased bioavailability through amorphous solid dispersions: a review |
| title_full_unstemmed | Mechanisms of increased bioavailability through amorphous solid dispersions: a review |
| title_short | Mechanisms of increased bioavailability through amorphous solid dispersions: a review |
| title_sort | mechanisms of increased bioavailability through amorphous solid dispersions a review |
| topic | amorphous solid dispersion excipients poorly water-soluble drugs oral bioavailability dissolution drug absorption |
| url | http://dx.doi.org/10.1080/10717544.2019.1704940 |
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