Neonatal intestinal dysbiosis in necrotizing enterocolitis
Abstract Necrotizing Enterocolitis (NEC) is one of the most devastating gastrointestinal diseases in neonates, particularly among preterm infants in whom surgical NEC is the leading cause of morbidity. NEC pathophysiology occurs in the hyper-reactive milieu of the premature gut after bacterial colon...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2018-03-01
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| Series: | Molecular Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s10020-018-0002-0 |
| _version_ | 1828199497560227840 |
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| author | Naomi-Liza Denning Jose M. Prince |
| author_facet | Naomi-Liza Denning Jose M. Prince |
| author_sort | Naomi-Liza Denning |
| collection | DOAJ |
| description | Abstract Necrotizing Enterocolitis (NEC) is one of the most devastating gastrointestinal diseases in neonates, particularly among preterm infants in whom surgical NEC is the leading cause of morbidity. NEC pathophysiology occurs in the hyper-reactive milieu of the premature gut after bacterial colonization. The resultant activation of the TLR4 pathway appears to be a strongly contributing factor. Advancements in metagenomics may yield new clarity to the relationship between the neonatal intestinal microbiome and the development of NEC. After a century without effective directed treatments, microbiome manipulation offers a promising therapeutic target for the prevention and treatment of this devastating disease. |
| first_indexed | 2024-04-12T10:56:04Z |
| format | Article |
| id | doaj.art-ea05dc56237542d8ad6410d85188d5e2 |
| institution | Directory Open Access Journal |
| issn | 1076-1551 1528-3658 |
| language | English |
| last_indexed | 2024-04-12T10:56:04Z |
| publishDate | 2018-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj.art-ea05dc56237542d8ad6410d85188d5e22022-12-22T03:36:06ZengBMCMolecular Medicine1076-15511528-36582018-03-0124111010.1186/s10020-018-0002-0Neonatal intestinal dysbiosis in necrotizing enterocolitisNaomi-Liza Denning0Jose M. Prince1Division of Pediatric Surgery, Zucker School of Medicine at Hofstra/Northwell, Cohen Children’s Medical CenterDivision of Pediatric Surgery, Zucker School of Medicine at Hofstra/Northwell, Cohen Children’s Medical CenterAbstract Necrotizing Enterocolitis (NEC) is one of the most devastating gastrointestinal diseases in neonates, particularly among preterm infants in whom surgical NEC is the leading cause of morbidity. NEC pathophysiology occurs in the hyper-reactive milieu of the premature gut after bacterial colonization. The resultant activation of the TLR4 pathway appears to be a strongly contributing factor. Advancements in metagenomics may yield new clarity to the relationship between the neonatal intestinal microbiome and the development of NEC. After a century without effective directed treatments, microbiome manipulation offers a promising therapeutic target for the prevention and treatment of this devastating disease.http://link.springer.com/article/10.1186/s10020-018-0002-0Neonatal sepsisMicrobiomeIntestinal failurePrematurityInflammation |
| spellingShingle | Naomi-Liza Denning Jose M. Prince Neonatal intestinal dysbiosis in necrotizing enterocolitis Molecular Medicine Neonatal sepsis Microbiome Intestinal failure Prematurity Inflammation |
| title | Neonatal intestinal dysbiosis in necrotizing enterocolitis |
| title_full | Neonatal intestinal dysbiosis in necrotizing enterocolitis |
| title_fullStr | Neonatal intestinal dysbiosis in necrotizing enterocolitis |
| title_full_unstemmed | Neonatal intestinal dysbiosis in necrotizing enterocolitis |
| title_short | Neonatal intestinal dysbiosis in necrotizing enterocolitis |
| title_sort | neonatal intestinal dysbiosis in necrotizing enterocolitis |
| topic | Neonatal sepsis Microbiome Intestinal failure Prematurity Inflammation |
| url | http://link.springer.com/article/10.1186/s10020-018-0002-0 |
| work_keys_str_mv | AT naomilizadenning neonatalintestinaldysbiosisinnecrotizingenterocolitis AT josemprince neonatalintestinaldysbiosisinnecrotizingenterocolitis |