Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus
Two new secondary metabolites, namely, pinodiketopiperazine A (1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide (2), along with alternariol 2,4-dimethyl ether (3) and l-5-oxoproline methyl ester (4), which were isolated from a natural source for the first time but have been previously synthesized, w...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-06-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/11/6/2230 |
| _version_ | 1798041365830959104 |
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| author | Bin-Gui Wang Nai-Yun Ji Chun-Shun Li Ming-Hui Wang Xiao-Ming Li |
| author_facet | Bin-Gui Wang Nai-Yun Ji Chun-Shun Li Ming-Hui Wang Xiao-Ming Li |
| author_sort | Bin-Gui Wang |
| collection | DOAJ |
| description | Two new secondary metabolites, namely, pinodiketopiperazine A (1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide (2), along with alternariol 2,4-dimethyl ether (3) and l-5-oxoproline methyl ester (4), which were isolated from a natural source for the first time but have been previously synthesized, were characterized from the marine sediment-derived fungus Penicillium pinophilum SD-272. In addition, six known metabolites (5–10) were also identified. Their structures were elucidated by analysis of the NMR and mass spectroscopic data. The absolute configuration of compound 1 was determined by experimental and calculated ECD spectra. Compound 2 displayed potent brine shrimp (Artemia salina) lethality with LD50 11.2 μM. |
| first_indexed | 2024-04-11T22:20:32Z |
| format | Article |
| id | doaj.art-ea07250b10294fb5b2a2a0ad2c8e94bf |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T22:20:32Z |
| publishDate | 2013-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-ea07250b10294fb5b2a2a0ad2c8e94bf2022-12-22T04:00:09ZengMDPI AGMarine Drugs1660-33972013-06-011162230223810.3390/md11062230Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived FungusBin-Gui WangNai-Yun JiChun-Shun LiMing-Hui WangXiao-Ming LiTwo new secondary metabolites, namely, pinodiketopiperazine A (1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide (2), along with alternariol 2,4-dimethyl ether (3) and l-5-oxoproline methyl ester (4), which were isolated from a natural source for the first time but have been previously synthesized, were characterized from the marine sediment-derived fungus Penicillium pinophilum SD-272. In addition, six known metabolites (5–10) were also identified. Their structures were elucidated by analysis of the NMR and mass spectroscopic data. The absolute configuration of compound 1 was determined by experimental and calculated ECD spectra. Compound 2 displayed potent brine shrimp (Artemia salina) lethality with LD50 11.2 μM.http://www.mdpi.com/1660-3397/11/6/2230sedimentPenicillium pinophilumsecondary metabolitebrine shrimp lethality |
| spellingShingle | Bin-Gui Wang Nai-Yun Ji Chun-Shun Li Ming-Hui Wang Xiao-Ming Li Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus Marine Drugs sediment Penicillium pinophilum secondary metabolite brine shrimp lethality |
| title | Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus |
| title_full | Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus |
| title_fullStr | Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus |
| title_full_unstemmed | Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus |
| title_short | Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus |
| title_sort | secondary metabolites from penicillium pinophilum sd 272 a marine sediment derived fungus |
| topic | sediment Penicillium pinophilum secondary metabolite brine shrimp lethality |
| url | http://www.mdpi.com/1660-3397/11/6/2230 |
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