Gut Microbiome-Related Anti-Inflammatory Effects of Aryl Hydrocarbon Receptor Activation on Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is one of the most prevalent chronic inflammations of the gastrointestinal tract (GIT). The gut microbial population, the cytokine milieu, the aryl hydrocarbon receptor (AHR) expressed by immune and nonimmune cells and the intrinsic pathway of Th-cell differentiation...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/6/3372 |
| _version_ | 1797240718963507200 |
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| author | Salvinaz Islam Moutusy Seiichiroh Ohsako |
| author_facet | Salvinaz Islam Moutusy Seiichiroh Ohsako |
| author_sort | Salvinaz Islam Moutusy |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is one of the most prevalent chronic inflammations of the gastrointestinal tract (GIT). The gut microbial population, the cytokine milieu, the aryl hydrocarbon receptor (AHR) expressed by immune and nonimmune cells and the intrinsic pathway of Th-cell differentiation are implicated in the immunopathology of IBD. AHR activation requires a delicate balance between regulatory and effector T-cells; loss of this balance can cause local gut microbial dysbiosis and intestinal inflammation. Thus, the study of the gut microbiome in association with AHR provides critical insights into IBD pathogenesis and interventions. This review will focus on the recent advancements to form conceptional frameworks on the benefits of AHR activation by commensal gut bacteria in IBD. |
| first_indexed | 2024-04-24T18:11:54Z |
| format | Article |
| id | doaj.art-ea078781e3b24f1e88e267560433c97a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-24T18:11:54Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ea078781e3b24f1e88e267560433c97a2024-03-27T13:45:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-03-01256337210.3390/ijms25063372Gut Microbiome-Related Anti-Inflammatory Effects of Aryl Hydrocarbon Receptor Activation on Inflammatory Bowel DiseaseSalvinaz Islam Moutusy0Seiichiroh Ohsako1Laboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, JapanLaboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, JapanInflammatory bowel disease (IBD) is one of the most prevalent chronic inflammations of the gastrointestinal tract (GIT). The gut microbial population, the cytokine milieu, the aryl hydrocarbon receptor (AHR) expressed by immune and nonimmune cells and the intrinsic pathway of Th-cell differentiation are implicated in the immunopathology of IBD. AHR activation requires a delicate balance between regulatory and effector T-cells; loss of this balance can cause local gut microbial dysbiosis and intestinal inflammation. Thus, the study of the gut microbiome in association with AHR provides critical insights into IBD pathogenesis and interventions. This review will focus on the recent advancements to form conceptional frameworks on the benefits of AHR activation by commensal gut bacteria in IBD.https://www.mdpi.com/1422-0067/25/6/3372inflammatory bowel diseases (IBD)aryl hydrocarbon receptor (AHR)gut microbiotainflammationdysbiosis |
| spellingShingle | Salvinaz Islam Moutusy Seiichiroh Ohsako Gut Microbiome-Related Anti-Inflammatory Effects of Aryl Hydrocarbon Receptor Activation on Inflammatory Bowel Disease International Journal of Molecular Sciences inflammatory bowel diseases (IBD) aryl hydrocarbon receptor (AHR) gut microbiota inflammation dysbiosis |
| title | Gut Microbiome-Related Anti-Inflammatory Effects of Aryl Hydrocarbon Receptor Activation on Inflammatory Bowel Disease |
| title_full | Gut Microbiome-Related Anti-Inflammatory Effects of Aryl Hydrocarbon Receptor Activation on Inflammatory Bowel Disease |
| title_fullStr | Gut Microbiome-Related Anti-Inflammatory Effects of Aryl Hydrocarbon Receptor Activation on Inflammatory Bowel Disease |
| title_full_unstemmed | Gut Microbiome-Related Anti-Inflammatory Effects of Aryl Hydrocarbon Receptor Activation on Inflammatory Bowel Disease |
| title_short | Gut Microbiome-Related Anti-Inflammatory Effects of Aryl Hydrocarbon Receptor Activation on Inflammatory Bowel Disease |
| title_sort | gut microbiome related anti inflammatory effects of aryl hydrocarbon receptor activation on inflammatory bowel disease |
| topic | inflammatory bowel diseases (IBD) aryl hydrocarbon receptor (AHR) gut microbiota inflammation dysbiosis |
| url | https://www.mdpi.com/1422-0067/25/6/3372 |
| work_keys_str_mv | AT salvinazislammoutusy gutmicrobiomerelatedantiinflammatoryeffectsofarylhydrocarbonreceptoractivationoninflammatoryboweldisease AT seiichirohohsako gutmicrobiomerelatedantiinflammatoryeffectsofarylhydrocarbonreceptoractivationoninflammatoryboweldisease |