Efficiency of a Tetracycline-Adjuvant Combination Against Multidrug Resistant <i>Pseudomonas aeruginosa</i> Tunisian Clinical Isolates
The growing number of multidrug resistant strains in Tunisia has become a serious health concern contributing to high rate of mortality and morbidity. Since current antibiotics are rapidly becoming ineffective, novel strategies to combat resistance are needed. Recently, we demonstrated that combinat...
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| Format: | Article |
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MDPI AG
2020-12-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/9/12/919 |
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| author | Azza Troudi Meha Fethi Mohamed Selim El Asli Jean Michel Bolla Naouel Klibi Jean Michel Brunel |
| author_facet | Azza Troudi Meha Fethi Mohamed Selim El Asli Jean Michel Bolla Naouel Klibi Jean Michel Brunel |
| author_sort | Azza Troudi |
| collection | DOAJ |
| description | The growing number of multidrug resistant strains in Tunisia has become a serious health concern contributing to high rate of mortality and morbidity. Since current antibiotics are rapidly becoming ineffective, novel strategies to combat resistance are needed. Recently, we demonstrated that combination of a tetracycline antibiotic with various polyaminoisoprenyl adjuvants can sustain the life span and enhance the activity of these drugs against <i>Pseudomonas aeruginosa</i> reference strain (PA01). In the context of our continuing studies, the effective approach of antibiotic-adjuvant was investigated against a large panel of <i>P. aeruginosa</i> Tunisian clinical strains collected from the Military Hospital of Tunis. In this paper, we demonstrated that the combination of a farnesyl spermine compound <b>3</b> used at concentrations ranging from 2.5 to 10 µM, in the presence of doxycycline or minocycline leads to a significant decrease of <i>P. aeruginosa</i> antibiotic resistance. |
| first_indexed | 2024-03-10T13:59:35Z |
| format | Article |
| id | doaj.art-ea08b816e0a649c988fbbcb63e421411 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T13:59:35Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-ea08b816e0a649c988fbbcb63e4214112023-11-21T01:21:31ZengMDPI AGAntibiotics2079-63822020-12-0191291910.3390/antibiotics9120919Efficiency of a Tetracycline-Adjuvant Combination Against Multidrug Resistant <i>Pseudomonas aeruginosa</i> Tunisian Clinical IsolatesAzza Troudi0Meha Fethi1Mohamed Selim El Asli2Jean Michel Bolla3Naouel Klibi4Jean Michel Brunel5Faculté de Pharmacie, Aix Marseille Universite, INSERM, SSA, MCT, 13385 Marseille, FranceLaboratory of Microorganisms and Active Biomolecules, Department of Biology, Faculty of Sciences of Tunis, University of Tunis, Tunis 1008, TunisiaService of Microbiology, Military Hospital of Tunis HMPIT, Tunis 1008, TunisiaFaculté de Pharmacie, Aix Marseille Universite, INSERM, SSA, MCT, 13385 Marseille, FranceLaboratory of Microorganisms and Active Biomolecules, Department of Biology, Faculty of Sciences of Tunis, University of Tunis, Tunis 1008, TunisiaFaculté de Pharmacie, Aix Marseille Universite, INSERM, SSA, MCT, 13385 Marseille, FranceThe growing number of multidrug resistant strains in Tunisia has become a serious health concern contributing to high rate of mortality and morbidity. Since current antibiotics are rapidly becoming ineffective, novel strategies to combat resistance are needed. Recently, we demonstrated that combination of a tetracycline antibiotic with various polyaminoisoprenyl adjuvants can sustain the life span and enhance the activity of these drugs against <i>Pseudomonas aeruginosa</i> reference strain (PA01). In the context of our continuing studies, the effective approach of antibiotic-adjuvant was investigated against a large panel of <i>P. aeruginosa</i> Tunisian clinical strains collected from the Military Hospital of Tunis. In this paper, we demonstrated that the combination of a farnesyl spermine compound <b>3</b> used at concentrations ranging from 2.5 to 10 µM, in the presence of doxycycline or minocycline leads to a significant decrease of <i>P. aeruginosa</i> antibiotic resistance.https://www.mdpi.com/2079-6382/9/12/919polyaminoisoprenyl derivativesantibiotic adjuvantspolyamines<i>Pseudomonas aeruginosa</i> clinical strainsdoxycyclineminocycline |
| spellingShingle | Azza Troudi Meha Fethi Mohamed Selim El Asli Jean Michel Bolla Naouel Klibi Jean Michel Brunel Efficiency of a Tetracycline-Adjuvant Combination Against Multidrug Resistant <i>Pseudomonas aeruginosa</i> Tunisian Clinical Isolates Antibiotics polyaminoisoprenyl derivatives antibiotic adjuvants polyamines <i>Pseudomonas aeruginosa</i> clinical strains doxycycline minocycline |
| title | Efficiency of a Tetracycline-Adjuvant Combination Against Multidrug Resistant <i>Pseudomonas aeruginosa</i> Tunisian Clinical Isolates |
| title_full | Efficiency of a Tetracycline-Adjuvant Combination Against Multidrug Resistant <i>Pseudomonas aeruginosa</i> Tunisian Clinical Isolates |
| title_fullStr | Efficiency of a Tetracycline-Adjuvant Combination Against Multidrug Resistant <i>Pseudomonas aeruginosa</i> Tunisian Clinical Isolates |
| title_full_unstemmed | Efficiency of a Tetracycline-Adjuvant Combination Against Multidrug Resistant <i>Pseudomonas aeruginosa</i> Tunisian Clinical Isolates |
| title_short | Efficiency of a Tetracycline-Adjuvant Combination Against Multidrug Resistant <i>Pseudomonas aeruginosa</i> Tunisian Clinical Isolates |
| title_sort | efficiency of a tetracycline adjuvant combination against multidrug resistant i pseudomonas aeruginosa i tunisian clinical isolates |
| topic | polyaminoisoprenyl derivatives antibiotic adjuvants polyamines <i>Pseudomonas aeruginosa</i> clinical strains doxycycline minocycline |
| url | https://www.mdpi.com/2079-6382/9/12/919 |
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