Clozapine Use During Pregnancy and Lactation: A Case-Series Report
The current prescription of clozapine in psychotic women of reproductive age makes it crucial to understand its pharmacokinetics during pregnancy and lactation as well as its risk profile for neonatal outcome. The aim of this case series was to provide new evidence on the pharmacokinetic features of...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphar.2018.00264/full |
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| author | M. Luisa Imaz M. Luisa Imaz Giovanni Oriolo Giovanni Oriolo Mercè Torra Mercè Torra Dolors Soy Lluïsa García-Esteve Lluïsa García-Esteve Rocio Martin-Santos Rocio Martin-Santos |
| author_facet | M. Luisa Imaz M. Luisa Imaz Giovanni Oriolo Giovanni Oriolo Mercè Torra Mercè Torra Dolors Soy Lluïsa García-Esteve Lluïsa García-Esteve Rocio Martin-Santos Rocio Martin-Santos |
| author_sort | M. Luisa Imaz |
| collection | DOAJ |
| description | The current prescription of clozapine in psychotic women of reproductive age makes it crucial to understand its pharmacokinetics during pregnancy and lactation as well as its risk profile for neonatal outcome. The aim of this case series was to provide new evidence on the pharmacokinetic features of clozapine that determine its passage through the placenta and amniotic fluid, as well as the neonatal clozapine elimination half-life (t1/2). This case series demonstrates for the first time that clozapine might show partial placental passage similar to other atypical antipsychotics. Clozapine levels decreased during the first few days in nursing infants. The half-life of clozapine in neonates was slightly higher than previously estimated. Clozapine use in pregnancy may be associated with diabetes mellitus, especially if there is a family history of this disease. Although no acute toxicological effects were observed in the intrauterine exposed newborn, close follow-up of pregnancy is recommended. However, these results must be taken with caution being a case series with small sample size |
| first_indexed | 2024-04-13T09:39:26Z |
| format | Article |
| id | doaj.art-ea0b4e84413f430e813fad3945418113 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T09:39:26Z |
| publishDate | 2018-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-ea0b4e84413f430e813fad39454181132022-12-22T02:51:59ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-03-01910.3389/fphar.2018.00264344206Clozapine Use During Pregnancy and Lactation: A Case-Series ReportM. Luisa Imaz0M. Luisa Imaz1Giovanni Oriolo2Giovanni Oriolo3Mercè Torra4Mercè Torra5Dolors Soy6Lluïsa García-Esteve7Lluïsa García-Esteve8Rocio Martin-Santos9Rocio Martin-Santos10Perinatal Psychiatry Program, Department of Psychiatry and Psychology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, SpainDepartment of Medicine, University of Barcelona, Barcelona, SpainDepartment of Medicine, University of Barcelona, Barcelona, SpainDepartment of Psychiatry and Psychology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, SpainDepartment of Medicine, University of Barcelona, Barcelona, SpainPharmacology and Toxicology Laboratory, Biochemistry and Molecular Genetics Service, Biomedical Diagnostic Center (CBD), Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, SpainDivision of Medicines, Pharmacy Service, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, SpainPerinatal Psychiatry Program, Department of Psychiatry and Psychology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, SpainDepartment of Medicine, University of Barcelona, Barcelona, SpainDepartment of Medicine, University of Barcelona, Barcelona, SpainDepartment of Psychiatry and Psychology, Hospital Clinic, Institut d'Investigacions Biomèdiques Artur Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM), Barcelona, SpainThe current prescription of clozapine in psychotic women of reproductive age makes it crucial to understand its pharmacokinetics during pregnancy and lactation as well as its risk profile for neonatal outcome. The aim of this case series was to provide new evidence on the pharmacokinetic features of clozapine that determine its passage through the placenta and amniotic fluid, as well as the neonatal clozapine elimination half-life (t1/2). This case series demonstrates for the first time that clozapine might show partial placental passage similar to other atypical antipsychotics. Clozapine levels decreased during the first few days in nursing infants. The half-life of clozapine in neonates was slightly higher than previously estimated. Clozapine use in pregnancy may be associated with diabetes mellitus, especially if there is a family history of this disease. Although no acute toxicological effects were observed in the intrauterine exposed newborn, close follow-up of pregnancy is recommended. However, these results must be taken with caution being a case series with small sample sizehttp://journal.frontiersin.org/article/10.3389/fphar.2018.00264/fullclozapinepregnancyplacentalpharmacokineticsamnioticlactation |
| spellingShingle | M. Luisa Imaz M. Luisa Imaz Giovanni Oriolo Giovanni Oriolo Mercè Torra Mercè Torra Dolors Soy Lluïsa García-Esteve Lluïsa García-Esteve Rocio Martin-Santos Rocio Martin-Santos Clozapine Use During Pregnancy and Lactation: A Case-Series Report Frontiers in Pharmacology clozapine pregnancy placental pharmacokinetics amniotic lactation |
| title | Clozapine Use During Pregnancy and Lactation: A Case-Series Report |
| title_full | Clozapine Use During Pregnancy and Lactation: A Case-Series Report |
| title_fullStr | Clozapine Use During Pregnancy and Lactation: A Case-Series Report |
| title_full_unstemmed | Clozapine Use During Pregnancy and Lactation: A Case-Series Report |
| title_short | Clozapine Use During Pregnancy and Lactation: A Case-Series Report |
| title_sort | clozapine use during pregnancy and lactation a case series report |
| topic | clozapine pregnancy placental pharmacokinetics amniotic lactation |
| url | http://journal.frontiersin.org/article/10.3389/fphar.2018.00264/full |
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