Evaluation of liver fibrosis and carotid intima-media thickness index (C-IMT) in patients with chronic hepatitis C virus before and after direct-acting antiviral treatment (DAA)
Introduction. Viral hepatitis is still a challenge for the medical world and research over the past decades has been aimed at discovering viable methods of prevention, diagnosis and treatment. Material and methods. Data analysed from 73 patients from ”Dr. Victor Babes” Clinical Hospital of Infectio...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2021-06-01
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| Series: | Romanian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | https://rjid.com.ro/articles/2021.2/RJID_2021_2_Art-07.pdf |
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| author | Raluca Mihaela Dirtu George Sebastian Gherlan Daniel Codreanu Valentina Simion Horia Nicolae Corneliu Petru Popescu Simin Aysel Florescu Emanoil Ceausu Petre Iacob Calistru |
| author_facet | Raluca Mihaela Dirtu George Sebastian Gherlan Daniel Codreanu Valentina Simion Horia Nicolae Corneliu Petru Popescu Simin Aysel Florescu Emanoil Ceausu Petre Iacob Calistru |
| author_sort | Raluca Mihaela Dirtu |
| collection | DOAJ |
| description | Introduction. Viral hepatitis is still a challenge for the medical world and research over the past decades has been aimed at discovering viable methods of prevention, diagnosis and treatment.
Material and methods. Data analysed from 73 patients from ”Dr. Victor Babes” Clinical Hospital of Infectious and Tropical Diseases and ”Dr. Victor Babes” Private Medical Clinic, both from Bucharest.
Results. Fibroscan assessment showed that patients predominantly have F2, F3, F4 Metavir fibrosis stage while FibroTest showed F3, F4 stage of fibrosis. It was observed a decrease in fibrosis stage after DAA treatment comparative to values before treatment (5.622 kPa average post-treatment comparative to 11.49 kPa before treatment, statistically significant with p value < 0.001). Chronic infection with hepatitis C virus is considered a risk factor for atherosclerosis correlated with a higher cardiovascular risk compared to the general population. Monitoring patients prior to and after DAA treatment is an efficient method to detect early vascular changes that could lead to thrombotic and/or cardiovascular events.
Conclusions. Measurement of the IMT index by doppler ultrasound in patients with hepatitis C virus infectionmay constitute a method of identification the endothelial dysfunction or atherosclerosis and may help to establish cardiovascular risk. Elimination of hepatitis C virus is the target of ongoing international programmes but the extrahepatic effects of persistent infection, early diagnosis and appropriate treatment should not be neglected. |
| first_indexed | 2024-04-14T01:05:51Z |
| format | Article |
| id | doaj.art-ea0ba01e9bc44517a9dab52f8f304f01 |
| institution | Directory Open Access Journal |
| issn | 1454-3389 2069-6051 |
| language | English |
| last_indexed | 2024-04-14T01:05:51Z |
| publishDate | 2021-06-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Infectious Diseases |
| spelling | doaj.art-ea0ba01e9bc44517a9dab52f8f304f012022-12-22T02:21:16ZengAmaltea Medical Publishing HouseRomanian Journal of Infectious Diseases1454-33892069-60512021-06-0124210310810.37897/RJID.2021.2.7Evaluation of liver fibrosis and carotid intima-media thickness index (C-IMT) in patients with chronic hepatitis C virus before and after direct-acting antiviral treatment (DAA)Raluca Mihaela Dirtu0George Sebastian Gherlan1Daniel Codreanu2Valentina Simion3Horia Nicolae4Corneliu Petru Popescu5Simin Aysel Florescu6Emanoil Ceausu7Petre Iacob Calistru8“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; “Dr. Victor Babes” Clinical Hospital of Infectious and Tropical Diseases, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; “Dr. Victor Babes” Clinical Hospital of Infectious and Tropical Diseases, Bucharest, Romania; “Dr. Victor Babes” Private Medical Clinic, Bucharest, Romania“Dr. Victor Babes” Clinical Hospital of Infectious and Tropical Diseases, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; “Dr. Victor Babes” Clinical Hospital of Infectious and Tropical Diseases, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; Elias University Emergency Hospital, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; “Dr. Victor Babes” Clinical Hospital of Infectious and Tropical Diseases, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; “Dr. Victor Babes” Clinical Hospital of Infectious and Tropical Diseases, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; “Dr. Victor Babes” Clinical Hospital of Infectious and Tropical Diseases, Bucharest, Romania; Academy of Medical Sciences, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; “Dr. Victor Babes” Clinical Hospital of Infectious and Tropical Diseases, Bucharest, Romania; “Dr. Victor Babes” Private Medical Clinic, Bucharest, RomaniaIntroduction. Viral hepatitis is still a challenge for the medical world and research over the past decades has been aimed at discovering viable methods of prevention, diagnosis and treatment. Material and methods. Data analysed from 73 patients from ”Dr. Victor Babes” Clinical Hospital of Infectious and Tropical Diseases and ”Dr. Victor Babes” Private Medical Clinic, both from Bucharest. Results. Fibroscan assessment showed that patients predominantly have F2, F3, F4 Metavir fibrosis stage while FibroTest showed F3, F4 stage of fibrosis. It was observed a decrease in fibrosis stage after DAA treatment comparative to values before treatment (5.622 kPa average post-treatment comparative to 11.49 kPa before treatment, statistically significant with p value < 0.001). Chronic infection with hepatitis C virus is considered a risk factor for atherosclerosis correlated with a higher cardiovascular risk compared to the general population. Monitoring patients prior to and after DAA treatment is an efficient method to detect early vascular changes that could lead to thrombotic and/or cardiovascular events. Conclusions. Measurement of the IMT index by doppler ultrasound in patients with hepatitis C virus infectionmay constitute a method of identification the endothelial dysfunction or atherosclerosis and may help to establish cardiovascular risk. Elimination of hepatitis C virus is the target of ongoing international programmes but the extrahepatic effects of persistent infection, early diagnosis and appropriate treatment should not be neglected.https://rjid.com.ro/articles/2021.2/RJID_2021_2_Art-07.pdfhepatitis virus cimtcardiovascularextrahepaticdaa |
| spellingShingle | Raluca Mihaela Dirtu George Sebastian Gherlan Daniel Codreanu Valentina Simion Horia Nicolae Corneliu Petru Popescu Simin Aysel Florescu Emanoil Ceausu Petre Iacob Calistru Evaluation of liver fibrosis and carotid intima-media thickness index (C-IMT) in patients with chronic hepatitis C virus before and after direct-acting antiviral treatment (DAA) Romanian Journal of Infectious Diseases hepatitis virus c imt cardiovascular extrahepatic daa |
| title | Evaluation of liver fibrosis and carotid intima-media thickness index (C-IMT) in patients with chronic hepatitis C virus before and after direct-acting antiviral treatment (DAA) |
| title_full | Evaluation of liver fibrosis and carotid intima-media thickness index (C-IMT) in patients with chronic hepatitis C virus before and after direct-acting antiviral treatment (DAA) |
| title_fullStr | Evaluation of liver fibrosis and carotid intima-media thickness index (C-IMT) in patients with chronic hepatitis C virus before and after direct-acting antiviral treatment (DAA) |
| title_full_unstemmed | Evaluation of liver fibrosis and carotid intima-media thickness index (C-IMT) in patients with chronic hepatitis C virus before and after direct-acting antiviral treatment (DAA) |
| title_short | Evaluation of liver fibrosis and carotid intima-media thickness index (C-IMT) in patients with chronic hepatitis C virus before and after direct-acting antiviral treatment (DAA) |
| title_sort | evaluation of liver fibrosis and carotid intima media thickness index c imt in patients with chronic hepatitis c virus before and after direct acting antiviral treatment daa |
| topic | hepatitis virus c imt cardiovascular extrahepatic daa |
| url | https://rjid.com.ro/articles/2021.2/RJID_2021_2_Art-07.pdf |
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