Emerging roles of mitochondrial sirtuin SIRT5 in succinylation modification and cancer development

Succinylation represents an emerging class of post-translational modifications (PTMs), characterized by the enzymatic or non-enzymatic transfer of a negatively charged four-carbon succinyl group to the ϵ-amino group of lysine residues, mediated by succinyl-coenzyme A. Recent studies have highlighted...

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Main Authors: Zhangmin Ke, Kaikai Shen, Li Wang, Hao Xu, Xia Pan, Zhenjue Qian, Yuting Wen, Tangfeng Lv, Xiuwei Zhang, Yong Song
פורמט: Article
שפה:English
יצא לאור: Frontiers Media S.A. 2025-01-01
סדרה:Frontiers in Immunology
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גישה מקוונת:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1531246/full