Tailoring ZE21B Alloy with Nature-Inspired Extracellular Matrix Secreted by Micro-Patterned Smooth Muscle Cells and Endothelial Cells to Promote Surface Biocompatibility
Delayed surface endothelialization is a bottleneck that restricts the further application of cardiovascular stents. It has been reported that the nature-inspired extracellular matrix (ECM) secreted by the hyaluronic acid (HA) micro-patterned smooth muscle cells (SMC) and endothelial cells (EC) can s...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/6/3180 |
| _version_ | 1797470928669507584 |
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| author | Changsheng Liu Lan Chen Kun Zhang Jingan Li Shaokang Guan |
| author_facet | Changsheng Liu Lan Chen Kun Zhang Jingan Li Shaokang Guan |
| author_sort | Changsheng Liu |
| collection | DOAJ |
| description | Delayed surface endothelialization is a bottleneck that restricts the further application of cardiovascular stents. It has been reported that the nature-inspired extracellular matrix (ECM) secreted by the hyaluronic acid (HA) micro-patterned smooth muscle cells (SMC) and endothelial cells (EC) can significantly promote surface endothelialization. However, this ECM coating obtained by decellularized method (dECM) is difficult to obtain directly on the surface of degradable magnesium (Mg) alloy. In this study, the method of obtaining bionic dECM by micro-patterning SMC/EC was further improved, and the nature-inspired ECM was prepared onto the Mg-Zn-Y-Nd (ZE21B) alloy surface by self-assembly. The results showed that the ECM coating not only improved surface endothelialization of ZE21B alloy, but also presented better blood compatibility, anti-hyperplasia, and anti-inflammation functions. The innovation and significance of the study is to overcome the disadvantage of traditional dECM coating and further expand the application of dECM coating to the surface of degradable materials and materials with different shapes. |
| first_indexed | 2024-03-09T19:42:53Z |
| format | Article |
| id | doaj.art-ea120e1e10c749bebef4c34c81cb6158 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T19:42:53Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ea120e1e10c749bebef4c34c81cb61582023-11-24T01:34:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01236318010.3390/ijms23063180Tailoring ZE21B Alloy with Nature-Inspired Extracellular Matrix Secreted by Micro-Patterned Smooth Muscle Cells and Endothelial Cells to Promote Surface BiocompatibilityChangsheng Liu0Lan Chen1Kun Zhang2Jingan Li3Shaokang Guan4School of Materials Science and Engineering, Zhengzhou University, 100 Science Road, Zhengzhou 450001, ChinaSchool of Materials Science and Engineering, Zhengzhou University, 100 Science Road, Zhengzhou 450001, ChinaSchool of Life Science, Zhengzhou University, 100 Science Road, Zhengzhou 450001, ChinaSchool of Materials Science and Engineering, Zhengzhou University, 100 Science Road, Zhengzhou 450001, ChinaSchool of Materials Science and Engineering, Zhengzhou University, 100 Science Road, Zhengzhou 450001, ChinaDelayed surface endothelialization is a bottleneck that restricts the further application of cardiovascular stents. It has been reported that the nature-inspired extracellular matrix (ECM) secreted by the hyaluronic acid (HA) micro-patterned smooth muscle cells (SMC) and endothelial cells (EC) can significantly promote surface endothelialization. However, this ECM coating obtained by decellularized method (dECM) is difficult to obtain directly on the surface of degradable magnesium (Mg) alloy. In this study, the method of obtaining bionic dECM by micro-patterning SMC/EC was further improved, and the nature-inspired ECM was prepared onto the Mg-Zn-Y-Nd (ZE21B) alloy surface by self-assembly. The results showed that the ECM coating not only improved surface endothelialization of ZE21B alloy, but also presented better blood compatibility, anti-hyperplasia, and anti-inflammation functions. The innovation and significance of the study is to overcome the disadvantage of traditional dECM coating and further expand the application of dECM coating to the surface of degradable materials and materials with different shapes.https://www.mdpi.com/1422-0067/23/6/3180cardiovascular materialsZE21B alloybiocompatibilitydECM coatinghyaluronic acid micro-patterns |
| spellingShingle | Changsheng Liu Lan Chen Kun Zhang Jingan Li Shaokang Guan Tailoring ZE21B Alloy with Nature-Inspired Extracellular Matrix Secreted by Micro-Patterned Smooth Muscle Cells and Endothelial Cells to Promote Surface Biocompatibility International Journal of Molecular Sciences cardiovascular materials ZE21B alloy biocompatibility dECM coating hyaluronic acid micro-patterns |
| title | Tailoring ZE21B Alloy with Nature-Inspired Extracellular Matrix Secreted by Micro-Patterned Smooth Muscle Cells and Endothelial Cells to Promote Surface Biocompatibility |
| title_full | Tailoring ZE21B Alloy with Nature-Inspired Extracellular Matrix Secreted by Micro-Patterned Smooth Muscle Cells and Endothelial Cells to Promote Surface Biocompatibility |
| title_fullStr | Tailoring ZE21B Alloy with Nature-Inspired Extracellular Matrix Secreted by Micro-Patterned Smooth Muscle Cells and Endothelial Cells to Promote Surface Biocompatibility |
| title_full_unstemmed | Tailoring ZE21B Alloy with Nature-Inspired Extracellular Matrix Secreted by Micro-Patterned Smooth Muscle Cells and Endothelial Cells to Promote Surface Biocompatibility |
| title_short | Tailoring ZE21B Alloy with Nature-Inspired Extracellular Matrix Secreted by Micro-Patterned Smooth Muscle Cells and Endothelial Cells to Promote Surface Biocompatibility |
| title_sort | tailoring ze21b alloy with nature inspired extracellular matrix secreted by micro patterned smooth muscle cells and endothelial cells to promote surface biocompatibility |
| topic | cardiovascular materials ZE21B alloy biocompatibility dECM coating hyaluronic acid micro-patterns |
| url | https://www.mdpi.com/1422-0067/23/6/3180 |
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