Walk Locomotion Kinematic Changes in a Model of Penetrating Hippocampal Injury in Male/Female Mice and Rats
Traumatic brain injury has been the leading cause of mortality and morbidity in human beings. One of the most susceptible structures to this damage is the hippocampus due to cellular and synaptic loss and impaired hippocampal connectivity to the brain, brain stem, and spinal cord. Thus, hippocampal...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/11/1545 |
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| author | Jonatan Alpirez Lilia Carolina Leon-Moreno Irene Guadalupe Aguilar-García Rolando Castañeda-Arellano Judith Marcela Dueñas-Jiménez Cesar Rodolfo Asencio-Piña Sergio Horacio Dueñas-Jiménez |
| author_facet | Jonatan Alpirez Lilia Carolina Leon-Moreno Irene Guadalupe Aguilar-García Rolando Castañeda-Arellano Judith Marcela Dueñas-Jiménez Cesar Rodolfo Asencio-Piña Sergio Horacio Dueñas-Jiménez |
| author_sort | Jonatan Alpirez |
| collection | DOAJ |
| description | Traumatic brain injury has been the leading cause of mortality and morbidity in human beings. One of the most susceptible structures to this damage is the hippocampus due to cellular and synaptic loss and impaired hippocampal connectivity to the brain, brain stem, and spinal cord. Thus, hippocampal damage in rodents using a stereotaxic device could be an adequate method to study a precise lesion from CA1 to the dentate gyrus structures. We studied male and female rats and mice, analyzing hindlimb locomotion kinematics changes to compare the locomotion kinematics using the same methodology in rodents. We measure (1) the vertical hindlimb metatarsus, ankle, and knee joint vertical displacements (VD) and (2) the factor of dissimilarity (DF). The VD in intact rats in metatarsus, ankle, and knee joints differs from that in intact mice in similar joints. In rats, the vertical displacement through the step cycle changed in the left and right metatarsus, ankle, and knee joints compared to the intact group versus the lesioned group. More subtle changes were also observed in mice. DF demonstrates contrasting results when studying locomotion kinematics of mice or rats and sex-dependent differences. Thus, a precise lesion in a rodent’s hippocampal structure discloses some hindlimb locomotion changes related to species and sex. Thus, we only have a qualitative comparison between murine species. In order to make a comparison with other species, we should standardize the model. |
| first_indexed | 2024-03-09T16:59:05Z |
| format | Article |
| id | doaj.art-ea12bf9aaac947e5935fd489e3dc9e43 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T16:59:05Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-ea12bf9aaac947e5935fd489e3dc9e432023-11-24T14:32:41ZengMDPI AGBrain Sciences2076-34252023-11-011311154510.3390/brainsci13111545Walk Locomotion Kinematic Changes in a Model of Penetrating Hippocampal Injury in Male/Female Mice and RatsJonatan Alpirez0Lilia Carolina Leon-Moreno1Irene Guadalupe Aguilar-García2Rolando Castañeda-Arellano3Judith Marcela Dueñas-Jiménez4Cesar Rodolfo Asencio-Piña5Sergio Horacio Dueñas-Jiménez6Departamento de Neurociencias, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoDepartamento de Neurociencias, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoDepartamento de Neurociencias, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoCentro de Investigación Multidisciplinario en Salud, Centro Universitario de Tonalá, Universidad de Guadalajara, Tonalá 45425, MexicoDepartamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoDepartamento de Electronica, Centro Universitario de Ciencias Exactas e Ingenierias, Universidad de Guadalajara, Guadalajara 44430, MexicoDepartamento de Neurociencias, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoTraumatic brain injury has been the leading cause of mortality and morbidity in human beings. One of the most susceptible structures to this damage is the hippocampus due to cellular and synaptic loss and impaired hippocampal connectivity to the brain, brain stem, and spinal cord. Thus, hippocampal damage in rodents using a stereotaxic device could be an adequate method to study a precise lesion from CA1 to the dentate gyrus structures. We studied male and female rats and mice, analyzing hindlimb locomotion kinematics changes to compare the locomotion kinematics using the same methodology in rodents. We measure (1) the vertical hindlimb metatarsus, ankle, and knee joint vertical displacements (VD) and (2) the factor of dissimilarity (DF). The VD in intact rats in metatarsus, ankle, and knee joints differs from that in intact mice in similar joints. In rats, the vertical displacement through the step cycle changed in the left and right metatarsus, ankle, and knee joints compared to the intact group versus the lesioned group. More subtle changes were also observed in mice. DF demonstrates contrasting results when studying locomotion kinematics of mice or rats and sex-dependent differences. Thus, a precise lesion in a rodent’s hippocampal structure discloses some hindlimb locomotion changes related to species and sex. Thus, we only have a qualitative comparison between murine species. In order to make a comparison with other species, we should standardize the model.https://www.mdpi.com/2076-3425/13/11/1545locomotion kinematicshippocampal injurymiceratssex differences |
| spellingShingle | Jonatan Alpirez Lilia Carolina Leon-Moreno Irene Guadalupe Aguilar-García Rolando Castañeda-Arellano Judith Marcela Dueñas-Jiménez Cesar Rodolfo Asencio-Piña Sergio Horacio Dueñas-Jiménez Walk Locomotion Kinematic Changes in a Model of Penetrating Hippocampal Injury in Male/Female Mice and Rats Brain Sciences locomotion kinematics hippocampal injury mice rats sex differences |
| title | Walk Locomotion Kinematic Changes in a Model of Penetrating Hippocampal Injury in Male/Female Mice and Rats |
| title_full | Walk Locomotion Kinematic Changes in a Model of Penetrating Hippocampal Injury in Male/Female Mice and Rats |
| title_fullStr | Walk Locomotion Kinematic Changes in a Model of Penetrating Hippocampal Injury in Male/Female Mice and Rats |
| title_full_unstemmed | Walk Locomotion Kinematic Changes in a Model of Penetrating Hippocampal Injury in Male/Female Mice and Rats |
| title_short | Walk Locomotion Kinematic Changes in a Model of Penetrating Hippocampal Injury in Male/Female Mice and Rats |
| title_sort | walk locomotion kinematic changes in a model of penetrating hippocampal injury in male female mice and rats |
| topic | locomotion kinematics hippocampal injury mice rats sex differences |
| url | https://www.mdpi.com/2076-3425/13/11/1545 |
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