Trabecular bone score and sclerostin concentrations in patients with primary adrenal insufficiency
BackgroundPatients with primary adrenal insufficiency need lifelong replacement therapy with glucocorticoids and mineralocorticoids, which may influence their bone quality.AimThe aim of the study was to evaluate densitometry parameters, trabecular bone score and sclerostin concentrations in patients...
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.996157/full |
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| author | Aleksandra Zdrojowy-Wełna Jowita Halupczok-Żyła Natalia Słoka Joanna Syrycka Łukasz Gojny Marek Bolanowski |
| author_facet | Aleksandra Zdrojowy-Wełna Jowita Halupczok-Żyła Natalia Słoka Joanna Syrycka Łukasz Gojny Marek Bolanowski |
| author_sort | Aleksandra Zdrojowy-Wełna |
| collection | DOAJ |
| description | BackgroundPatients with primary adrenal insufficiency need lifelong replacement therapy with glucocorticoids and mineralocorticoids, which may influence their bone quality.AimThe aim of the study was to evaluate densitometry parameters, trabecular bone score and sclerostin concentrations in patients with primary adrenal insufficiency in comparison to control group.Materials and methodsWe included 29 patients (62% females) with diagnose of autoimmune primary adrenal insufficiency (mean age 49.7 ± 11.7 years, mean duration of the disease 13.2± 13.6 years) and 33 healthy subjects (adjusted with age, sex and body mass index). Bone mineral density at the femoral neck, lumbar spine, total body and trabecular bone score were evaluated. Serum sclerostin concentrations were measured.ResultsThere were no significant differences in densitometry parameters (T-score, Z-score, bone mineral density in all locations) as well as in trabecular bone score in patients with adrenal insufficiency in comparison to control group. Mean serum sclerostin concentration was significantly higher in patients with adrenal insufficiency than in control group (44.7 ± 23.5 vs 30.7 ± 10.4 pmol/l, p=0.006). There was a negative correlation between trabecular bone score and the duration of adrenal insufficiency and age, also a negative correlation between femoral neck and total densitometry parameters and 24-hour urine cortisol as a marker of hydrocortisone daily dose in patients with adrenal insufficiency.ConclusionsThe bone status in patients with primary adrenal insufficiency was not impaired in comparison to control group, while sclerostin concentration was higher. The duration of the disease and higher hydrocortisone doses may affect negatively bone status. |
| first_indexed | 2024-04-11T23:36:22Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T23:36:22Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-ea139a0fd81d40bb94baa8c45ae1f2cd2022-12-22T03:56:57ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-11-011310.3389/fendo.2022.996157996157Trabecular bone score and sclerostin concentrations in patients with primary adrenal insufficiencyAleksandra Zdrojowy-Wełna0Jowita Halupczok-Żyła1Natalia Słoka2Joanna Syrycka3Łukasz Gojny4Marek Bolanowski5Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wroclaw, PolandDepartment of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wroclaw, PolandLaboratory of Molecular Endocrinology, Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wroclaw, PolandDepartment of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wroclaw, PolandDepartment of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wroclaw, PolandDepartment of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wroclaw, PolandBackgroundPatients with primary adrenal insufficiency need lifelong replacement therapy with glucocorticoids and mineralocorticoids, which may influence their bone quality.AimThe aim of the study was to evaluate densitometry parameters, trabecular bone score and sclerostin concentrations in patients with primary adrenal insufficiency in comparison to control group.Materials and methodsWe included 29 patients (62% females) with diagnose of autoimmune primary adrenal insufficiency (mean age 49.7 ± 11.7 years, mean duration of the disease 13.2± 13.6 years) and 33 healthy subjects (adjusted with age, sex and body mass index). Bone mineral density at the femoral neck, lumbar spine, total body and trabecular bone score were evaluated. Serum sclerostin concentrations were measured.ResultsThere were no significant differences in densitometry parameters (T-score, Z-score, bone mineral density in all locations) as well as in trabecular bone score in patients with adrenal insufficiency in comparison to control group. Mean serum sclerostin concentration was significantly higher in patients with adrenal insufficiency than in control group (44.7 ± 23.5 vs 30.7 ± 10.4 pmol/l, p=0.006). There was a negative correlation between trabecular bone score and the duration of adrenal insufficiency and age, also a negative correlation between femoral neck and total densitometry parameters and 24-hour urine cortisol as a marker of hydrocortisone daily dose in patients with adrenal insufficiency.ConclusionsThe bone status in patients with primary adrenal insufficiency was not impaired in comparison to control group, while sclerostin concentration was higher. The duration of the disease and higher hydrocortisone doses may affect negatively bone status.https://www.frontiersin.org/articles/10.3389/fendo.2022.996157/fullprimary adrenal insufficiencysclerostintrabecular bone scorebone mineral densityAddison’s disease |
| spellingShingle | Aleksandra Zdrojowy-Wełna Jowita Halupczok-Żyła Natalia Słoka Joanna Syrycka Łukasz Gojny Marek Bolanowski Trabecular bone score and sclerostin concentrations in patients with primary adrenal insufficiency Frontiers in Endocrinology primary adrenal insufficiency sclerostin trabecular bone score bone mineral density Addison’s disease |
| title | Trabecular bone score and sclerostin concentrations in patients with primary adrenal insufficiency |
| title_full | Trabecular bone score and sclerostin concentrations in patients with primary adrenal insufficiency |
| title_fullStr | Trabecular bone score and sclerostin concentrations in patients with primary adrenal insufficiency |
| title_full_unstemmed | Trabecular bone score and sclerostin concentrations in patients with primary adrenal insufficiency |
| title_short | Trabecular bone score and sclerostin concentrations in patients with primary adrenal insufficiency |
| title_sort | trabecular bone score and sclerostin concentrations in patients with primary adrenal insufficiency |
| topic | primary adrenal insufficiency sclerostin trabecular bone score bone mineral density Addison’s disease |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.996157/full |
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