Injectable hydrogels delivering therapeutic agents for disease treatment and tissue engineering
Abstract Background Injectable hydrogels have been extensively researched for the use as scaffolds or as carriers of therapeutic agents such as drugs, cells, proteins, and bioactive molecules in the treatment of diseases and cancers and the repair and regeneration of tissues. It is because they have...
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2018-09-01
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| Series: | Biomaterials Research |
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| Online Access: | http://link.springer.com/article/10.1186/s40824-018-0138-6 |
| _version_ | 1797283203430481920 |
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| author | Jin Hyun Lee |
| author_facet | Jin Hyun Lee |
| author_sort | Jin Hyun Lee |
| collection | DOAJ |
| description | Abstract Background Injectable hydrogels have been extensively researched for the use as scaffolds or as carriers of therapeutic agents such as drugs, cells, proteins, and bioactive molecules in the treatment of diseases and cancers and the repair and regeneration of tissues. It is because they have the injectability with minimal invasiveness and usability for irregularly shaped sites, in addition to typical advantages of conventional hydrogels such as biocompatibility, permeability to oxygen and nutrient, properties similar to the characteristics of the native extracellular matrix, and porous structure allowing therapeutic agents to be loaded. Main body In this article, recent studies of injectable hydrogel systems applicable for therapeutic agent delivery, disease/cancer therapy, and tissue engineering have reviewed in terms of the various factors physically and chemically contributing to sol-gel transition via which gels have been formed. The various factors are as follows: several different non-covalent interactions resulting in physical crosslinking (the electrostatic interactions (e.g., the ionic and hydrogen bonds), hydrophobic interactions, π-interactions, and van der Waals forces), in-situ chemical reactions inducing chemical crosslinking (the Diels Alder click reactions, Michael reactions, Schiff base reactions, or enzyme-or photo-mediated reactions), and external stimuli (temperatures, pHs, lights, electric/magnetic fields, ultrasounds, or biomolecular species (e.g., enzyme)). Finally, their applications with accompanying therapeutic agents and notable properties used were reviewed as well. Conclusion Injectable hydrogels, of which network morphology and properties could be tuned, have shown to control the load and release of therapeutic agents, consequently producing significant therapeutic efficacy. Accordingly, they are believed to be successful and promising biomaterials as scaffolds and carriers of therapeutic agents for disease and cancer therapy and tissue engineering. |
| first_indexed | 2024-03-07T17:26:43Z |
| format | Article |
| id | doaj.art-ea163846ba6b42bfab6b466b80053bf7 |
| institution | Directory Open Access Journal |
| issn | 2055-7124 |
| language | English |
| last_indexed | 2024-03-07T17:26:43Z |
| publishDate | 2018-09-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Biomaterials Research |
| spelling | doaj.art-ea163846ba6b42bfab6b466b80053bf72024-03-02T19:05:16ZengAmerican Association for the Advancement of Science (AAAS)Biomaterials Research2055-71242018-09-0122111410.1186/s40824-018-0138-6Injectable hydrogels delivering therapeutic agents for disease treatment and tissue engineeringJin Hyun Lee0Polymer Technology Institute, Sungkyunkwan UniversityAbstract Background Injectable hydrogels have been extensively researched for the use as scaffolds or as carriers of therapeutic agents such as drugs, cells, proteins, and bioactive molecules in the treatment of diseases and cancers and the repair and regeneration of tissues. It is because they have the injectability with minimal invasiveness and usability for irregularly shaped sites, in addition to typical advantages of conventional hydrogels such as biocompatibility, permeability to oxygen and nutrient, properties similar to the characteristics of the native extracellular matrix, and porous structure allowing therapeutic agents to be loaded. Main body In this article, recent studies of injectable hydrogel systems applicable for therapeutic agent delivery, disease/cancer therapy, and tissue engineering have reviewed in terms of the various factors physically and chemically contributing to sol-gel transition via which gels have been formed. The various factors are as follows: several different non-covalent interactions resulting in physical crosslinking (the electrostatic interactions (e.g., the ionic and hydrogen bonds), hydrophobic interactions, π-interactions, and van der Waals forces), in-situ chemical reactions inducing chemical crosslinking (the Diels Alder click reactions, Michael reactions, Schiff base reactions, or enzyme-or photo-mediated reactions), and external stimuli (temperatures, pHs, lights, electric/magnetic fields, ultrasounds, or biomolecular species (e.g., enzyme)). Finally, their applications with accompanying therapeutic agents and notable properties used were reviewed as well. Conclusion Injectable hydrogels, of which network morphology and properties could be tuned, have shown to control the load and release of therapeutic agents, consequently producing significant therapeutic efficacy. Accordingly, they are believed to be successful and promising biomaterials as scaffolds and carriers of therapeutic agents for disease and cancer therapy and tissue engineering.http://link.springer.com/article/10.1186/s40824-018-0138-6Injectable hydrogelsTherapeutic agent deliveryCrosslinking reactionDisease and cancer therapyTissue repair and regeneration |
| spellingShingle | Jin Hyun Lee Injectable hydrogels delivering therapeutic agents for disease treatment and tissue engineering Biomaterials Research Injectable hydrogels Therapeutic agent delivery Crosslinking reaction Disease and cancer therapy Tissue repair and regeneration |
| title | Injectable hydrogels delivering therapeutic agents for disease treatment and tissue engineering |
| title_full | Injectable hydrogels delivering therapeutic agents for disease treatment and tissue engineering |
| title_fullStr | Injectable hydrogels delivering therapeutic agents for disease treatment and tissue engineering |
| title_full_unstemmed | Injectable hydrogels delivering therapeutic agents for disease treatment and tissue engineering |
| title_short | Injectable hydrogels delivering therapeutic agents for disease treatment and tissue engineering |
| title_sort | injectable hydrogels delivering therapeutic agents for disease treatment and tissue engineering |
| topic | Injectable hydrogels Therapeutic agent delivery Crosslinking reaction Disease and cancer therapy Tissue repair and regeneration |
| url | http://link.springer.com/article/10.1186/s40824-018-0138-6 |
| work_keys_str_mv | AT jinhyunlee injectablehydrogelsdeliveringtherapeuticagentsfordiseasetreatmentandtissueengineering |