<i>Pseudomonas aeruginosa</i> Resistance to Bacteriophages and Its Prevention by Strategic Therapeutic Cocktail Formulation
Antimicrobial resistance poses a significant threat to modern healthcare as it limits treatment options for bacterial infections, particularly impacting those with chronic conditions such as cystic fibrosis (CF). Viscous mucus accumulation in the lungs of individuals genetically predisposed to CF le...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/2/145 |
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| author | Andrew Vaitekenas Anna S. Tai Joshua P. Ramsay Stephen M. Stick Anthony Kicic |
| author_facet | Andrew Vaitekenas Anna S. Tai Joshua P. Ramsay Stephen M. Stick Anthony Kicic |
| author_sort | Andrew Vaitekenas |
| collection | DOAJ |
| description | Antimicrobial resistance poses a significant threat to modern healthcare as it limits treatment options for bacterial infections, particularly impacting those with chronic conditions such as cystic fibrosis (CF). Viscous mucus accumulation in the lungs of individuals genetically predisposed to CF leads to recurrent bacterial infections, necessitating prolonged antimicrobial chemotherapy. <i>Pseudomonas aeruginosa</i> infections are the predominant driver of CF lung disease, and airway isolates are frequently resistant to multiple antimicrobials. Bacteriophages, or phages, are viruses that specifically infect bacteria and are a promising alternative to antimicrobials for CF <i>P. aeruginosa</i> infections. However, the narrow host range of <i>P. aeruginosa</i>-targeting phages and the rapid evolution of phage resistance could limit the clinical efficacy of phage therapy. A promising approach to overcome these issues is the strategic development of mixtures of phages (cocktails). The aim is to combine phages with broad host ranges and target multiple distinct bacterial receptors to prevent the evolution of phage resistance. However, further research is required to identify and characterize phage resistance mechanisms in CF-derived <i>P. aeruginosa,</i> which differ from their non-CF counterparts. In this review, we consider the mechanisms of <i>P. aeruginosa</i> phage resistance and how these could be overcome by an effective future phage therapy formulation. |
| first_indexed | 2024-03-09T06:09:52Z |
| format | Article |
| id | doaj.art-ea16bc3038ed4ec0af3a8956ce0826a1 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T06:09:52Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-ea16bc3038ed4ec0af3a8956ce0826a12023-12-03T12:00:17ZengMDPI AGAntibiotics2079-63822021-02-0110214510.3390/antibiotics10020145<i>Pseudomonas aeruginosa</i> Resistance to Bacteriophages and Its Prevention by Strategic Therapeutic Cocktail FormulationAndrew Vaitekenas0Anna S. Tai1Joshua P. Ramsay2Stephen M. Stick3Anthony Kicic4Occupation and the Environment, School of Public Health, Curtin University, Perth, WA 6102, AustraliaDepartment of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, WA 6009, AustraliaCurtin Medical School and Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6102, AustraliaWal-Yan Respiratory Research Centre, Telethon Kids Institute, The University of Western Australia, Crawley, WA 6009, AustraliaOccupation and the Environment, School of Public Health, Curtin University, Perth, WA 6102, AustraliaAntimicrobial resistance poses a significant threat to modern healthcare as it limits treatment options for bacterial infections, particularly impacting those with chronic conditions such as cystic fibrosis (CF). Viscous mucus accumulation in the lungs of individuals genetically predisposed to CF leads to recurrent bacterial infections, necessitating prolonged antimicrobial chemotherapy. <i>Pseudomonas aeruginosa</i> infections are the predominant driver of CF lung disease, and airway isolates are frequently resistant to multiple antimicrobials. Bacteriophages, or phages, are viruses that specifically infect bacteria and are a promising alternative to antimicrobials for CF <i>P. aeruginosa</i> infections. However, the narrow host range of <i>P. aeruginosa</i>-targeting phages and the rapid evolution of phage resistance could limit the clinical efficacy of phage therapy. A promising approach to overcome these issues is the strategic development of mixtures of phages (cocktails). The aim is to combine phages with broad host ranges and target multiple distinct bacterial receptors to prevent the evolution of phage resistance. However, further research is required to identify and characterize phage resistance mechanisms in CF-derived <i>P. aeruginosa,</i> which differ from their non-CF counterparts. In this review, we consider the mechanisms of <i>P. aeruginosa</i> phage resistance and how these could be overcome by an effective future phage therapy formulation.https://www.mdpi.com/2079-6382/10/2/145phage resistancebacteriophages<i>Pseudomonas aeruginosa</i>cystic fibrosisphage therapy |
| spellingShingle | Andrew Vaitekenas Anna S. Tai Joshua P. Ramsay Stephen M. Stick Anthony Kicic <i>Pseudomonas aeruginosa</i> Resistance to Bacteriophages and Its Prevention by Strategic Therapeutic Cocktail Formulation Antibiotics phage resistance bacteriophages <i>Pseudomonas aeruginosa</i> cystic fibrosis phage therapy |
| title | <i>Pseudomonas aeruginosa</i> Resistance to Bacteriophages and Its Prevention by Strategic Therapeutic Cocktail Formulation |
| title_full | <i>Pseudomonas aeruginosa</i> Resistance to Bacteriophages and Its Prevention by Strategic Therapeutic Cocktail Formulation |
| title_fullStr | <i>Pseudomonas aeruginosa</i> Resistance to Bacteriophages and Its Prevention by Strategic Therapeutic Cocktail Formulation |
| title_full_unstemmed | <i>Pseudomonas aeruginosa</i> Resistance to Bacteriophages and Its Prevention by Strategic Therapeutic Cocktail Formulation |
| title_short | <i>Pseudomonas aeruginosa</i> Resistance to Bacteriophages and Its Prevention by Strategic Therapeutic Cocktail Formulation |
| title_sort | i pseudomonas aeruginosa i resistance to bacteriophages and its prevention by strategic therapeutic cocktail formulation |
| topic | phage resistance bacteriophages <i>Pseudomonas aeruginosa</i> cystic fibrosis phage therapy |
| url | https://www.mdpi.com/2079-6382/10/2/145 |
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