Gamma-glutamyltransferase, possible novel biomarker in colon diverticulosis: a case-control study
The gamma-glutamyltransferase (GGT) is recognized in medical practice as a useful indicator for the detection of liver lesions, especially those induced by the excessive consumption of alcoholic or cholesterol-associated drinks. The present study, although it includes a very small number of cases di...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-01-01
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| Series: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/14756366.2018.1428802 |
| _version_ | 1798043028979449856 |
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| author | Constantin Bălăeţ Bogdan Ioan Coculescu Gheorghe Manole Maria Bălăeţ Gabi Valeriu Dincă |
| author_facet | Constantin Bălăeţ Bogdan Ioan Coculescu Gheorghe Manole Maria Bălăeţ Gabi Valeriu Dincă |
| author_sort | Constantin Bălăeţ |
| collection | DOAJ |
| description | The gamma-glutamyltransferase (GGT) is recognized in medical practice as a useful indicator for the detection of liver lesions, especially those induced by the excessive consumption of alcoholic or cholesterol-associated drinks. The present study, although it includes a very small number of cases diagnosed with colon diverticulosis-diverticulitis associated with polyposis at the same intestinal level, identifies the presence of increased circulating concentrations of this enzyme in the serum. Its serum levels are tracked “dynamically” throughout a year after the diagnosis and start of the therapy. The study calls into question the release of the enzyme from the edge of the enterocytes’ brush-like edge, leading to the pathogenic disturbance of regional redox homeostasis. The hypothesis gives the circulating values of GGT predictive value for cellular oxidative stress, as well as for indirectly expressing the glutathione level in cytosol. |
| first_indexed | 2024-04-11T22:43:55Z |
| format | Article |
| id | doaj.art-ea18c042076e47e99b8400d9beedf37e |
| institution | Directory Open Access Journal |
| issn | 1475-6366 1475-6374 |
| language | English |
| last_indexed | 2024-04-11T22:43:55Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Enzyme Inhibition and Medicinal Chemistry |
| spelling | doaj.art-ea18c042076e47e99b8400d9beedf37e2022-12-22T03:58:51ZengTaylor & Francis GroupJournal of Enzyme Inhibition and Medicinal Chemistry1475-63661475-63742018-01-0133142843210.1080/14756366.2018.14288021428802Gamma-glutamyltransferase, possible novel biomarker in colon diverticulosis: a case-control studyConstantin Bălăeţ0Bogdan Ioan Coculescu1Gheorghe Manole2Maria Bălăeţ3Gabi Valeriu Dincă4Bioterra UniversityBioterra UniversityTitu Maiorescu UniversityImperial College LondonTitu Maiorescu UniversityThe gamma-glutamyltransferase (GGT) is recognized in medical practice as a useful indicator for the detection of liver lesions, especially those induced by the excessive consumption of alcoholic or cholesterol-associated drinks. The present study, although it includes a very small number of cases diagnosed with colon diverticulosis-diverticulitis associated with polyposis at the same intestinal level, identifies the presence of increased circulating concentrations of this enzyme in the serum. Its serum levels are tracked “dynamically” throughout a year after the diagnosis and start of the therapy. The study calls into question the release of the enzyme from the edge of the enterocytes’ brush-like edge, leading to the pathogenic disturbance of regional redox homeostasis. The hypothesis gives the circulating values of GGT predictive value for cellular oxidative stress, as well as for indirectly expressing the glutathione level in cytosol.http://dx.doi.org/10.1080/14756366.2018.1428802Gamma-glutamyltransferaseinflammation markercolon polyposisoxidative stress |
| spellingShingle | Constantin Bălăeţ Bogdan Ioan Coculescu Gheorghe Manole Maria Bălăeţ Gabi Valeriu Dincă Gamma-glutamyltransferase, possible novel biomarker in colon diverticulosis: a case-control study Journal of Enzyme Inhibition and Medicinal Chemistry Gamma-glutamyltransferase inflammation marker colon polyposis oxidative stress |
| title | Gamma-glutamyltransferase, possible novel biomarker in colon diverticulosis: a case-control study |
| title_full | Gamma-glutamyltransferase, possible novel biomarker in colon diverticulosis: a case-control study |
| title_fullStr | Gamma-glutamyltransferase, possible novel biomarker in colon diverticulosis: a case-control study |
| title_full_unstemmed | Gamma-glutamyltransferase, possible novel biomarker in colon diverticulosis: a case-control study |
| title_short | Gamma-glutamyltransferase, possible novel biomarker in colon diverticulosis: a case-control study |
| title_sort | gamma glutamyltransferase possible novel biomarker in colon diverticulosis a case control study |
| topic | Gamma-glutamyltransferase inflammation marker colon polyposis oxidative stress |
| url | http://dx.doi.org/10.1080/14756366.2018.1428802 |
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