Cellular Signal Transductions and Their Inhibitors Derived from Deep-Sea Organisms
Not only physiological phenomena but also pathological phenomena can now be explained by the change of signal transduction in the cells of specific tissues. Commonly used cellular signal transductions are limited. They consist of the protein–tyrosine kinase dependent or independent Ras-ERK pathway,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/19/4/205 |
| _version_ | 1797538777138200576 |
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| author | Liyan Wang Kazuo Umezawa |
| author_facet | Liyan Wang Kazuo Umezawa |
| author_sort | Liyan Wang |
| collection | DOAJ |
| description | Not only physiological phenomena but also pathological phenomena can now be explained by the change of signal transduction in the cells of specific tissues. Commonly used cellular signal transductions are limited. They consist of the protein–tyrosine kinase dependent or independent Ras-ERK pathway, and the PI3K-Akt, JAK-STAT, SMAD, and NF-κB-activation pathways. In addition, biodegradation systems, such as the ubiquitin–proteasome pathway and autophagy, are also important for physiological and pathological conditions. If we can control signaling for each by a low-molecular-weight agent, it would be possible to treat diseases in new ways. At present, such cell signaling inhibitors are mainly looked for in plants, soil microorganisms, and the chemical library. The screening of bioactive metabolites from deep-sea organisms should be valuable because of the high incidence of finding novel compounds. Although it is still an emerging field, there are many successful examples, with new cell signaling inhibitors. In this review, we would like to explain the current view of the cell signaling systems important in diseases, and show the inhibitors found from deep-sea organisms, with their structures and biological activities. These inhibitors are possible candidates for anti-inflammatory agents, modulators of metabolic syndromes, antimicrobial agents, and anticancer agents. |
| first_indexed | 2024-03-10T12:36:14Z |
| format | Article |
| id | doaj.art-ea1971bddd764e9ebd04704202295d0f |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T12:36:14Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-ea1971bddd764e9ebd04704202295d0f2023-11-21T14:16:10ZengMDPI AGMarine Drugs1660-33972021-04-0119420510.3390/md19040205Cellular Signal Transductions and Their Inhibitors Derived from Deep-Sea OrganismsLiyan Wang0Kazuo Umezawa1Shenzhen Key Laboratory of Marine Bioresource and Eco-Environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, ChinaMolecular Target Medicine, School of Medicine, Aichi Medical University, Nagakute 480-1195, JapanNot only physiological phenomena but also pathological phenomena can now be explained by the change of signal transduction in the cells of specific tissues. Commonly used cellular signal transductions are limited. They consist of the protein–tyrosine kinase dependent or independent Ras-ERK pathway, and the PI3K-Akt, JAK-STAT, SMAD, and NF-κB-activation pathways. In addition, biodegradation systems, such as the ubiquitin–proteasome pathway and autophagy, are also important for physiological and pathological conditions. If we can control signaling for each by a low-molecular-weight agent, it would be possible to treat diseases in new ways. At present, such cell signaling inhibitors are mainly looked for in plants, soil microorganisms, and the chemical library. The screening of bioactive metabolites from deep-sea organisms should be valuable because of the high incidence of finding novel compounds. Although it is still an emerging field, there are many successful examples, with new cell signaling inhibitors. In this review, we would like to explain the current view of the cell signaling systems important in diseases, and show the inhibitors found from deep-sea organisms, with their structures and biological activities. These inhibitors are possible candidates for anti-inflammatory agents, modulators of metabolic syndromes, antimicrobial agents, and anticancer agents.https://www.mdpi.com/1660-3397/19/4/205cellular signal transductionbioactive metabolitedeep-sea organismsanti-inflammatory agentanticancer agent |
| spellingShingle | Liyan Wang Kazuo Umezawa Cellular Signal Transductions and Their Inhibitors Derived from Deep-Sea Organisms Marine Drugs cellular signal transduction bioactive metabolite deep-sea organisms anti-inflammatory agent anticancer agent |
| title | Cellular Signal Transductions and Their Inhibitors Derived from Deep-Sea Organisms |
| title_full | Cellular Signal Transductions and Their Inhibitors Derived from Deep-Sea Organisms |
| title_fullStr | Cellular Signal Transductions and Their Inhibitors Derived from Deep-Sea Organisms |
| title_full_unstemmed | Cellular Signal Transductions and Their Inhibitors Derived from Deep-Sea Organisms |
| title_short | Cellular Signal Transductions and Their Inhibitors Derived from Deep-Sea Organisms |
| title_sort | cellular signal transductions and their inhibitors derived from deep sea organisms |
| topic | cellular signal transduction bioactive metabolite deep-sea organisms anti-inflammatory agent anticancer agent |
| url | https://www.mdpi.com/1660-3397/19/4/205 |
| work_keys_str_mv | AT liyanwang cellularsignaltransductionsandtheirinhibitorsderivedfromdeepseaorganisms AT kazuoumezawa cellularsignaltransductionsandtheirinhibitorsderivedfromdeepseaorganisms |