Signaling pathways regulating the specification and differentiation of the osteoblast lineage
Tissue engineering is an approach to the regeneration of tissues that uses a combination of cell sources, signaling factors and scaffolds. Among these three components, signaling factors for bone regeneration have not yet been established, and it is necessary to better understand osteoblast progenit...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-06-01
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| Series: | Regenerative Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320414000030 |
| _version_ | 1819280636588851200 |
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| author | Hironori Hojo Shinsuke Ohba Ung-il Chung |
| author_facet | Hironori Hojo Shinsuke Ohba Ung-il Chung |
| author_sort | Hironori Hojo |
| collection | DOAJ |
| description | Tissue engineering is an approach to the regeneration of tissues that uses a combination of cell sources, signaling factors and scaffolds. Among these three components, signaling factors for bone regeneration have not yet been established, and it is necessary to better understand osteoblast progenitors as a target cells. Several lines of evidence have revealed that, during bone formation, mesenchymal cells are specified and differentiate into osteoblasts through several stages of precursors. The osteoblast lineage is defined by the expression of stage-specific transcription factors. The specification and differentiation are organized by a variety of signaling pathways including hedgehog (Hh), Wnt, Notch, bone morphogenetic protein (BMP) and transforming growth factor-beta (TGFβ). In this review we integrate the known functions of these signaling pathways and discuss future tasks to gain a better understanding of the signaling network in osteogenesis for tissue engineering. |
| first_indexed | 2024-12-24T00:46:57Z |
| format | Article |
| id | doaj.art-ea1a2079c26f4b2fb554222504f09b4e |
| institution | Directory Open Access Journal |
| issn | 2352-3204 |
| language | English |
| last_indexed | 2024-12-24T00:46:57Z |
| publishDate | 2015-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj.art-ea1a2079c26f4b2fb554222504f09b4e2022-12-21T17:23:47ZengElsevierRegenerative Therapy2352-32042015-06-011C576210.1016/j.reth.2014.10.002Signaling pathways regulating the specification and differentiation of the osteoblast lineageHironori Hojo0Shinsuke Ohba1Ung-il Chung2Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, 1425 San Pablo St, Los Angeles, CA 90089, USACenter for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanCenter for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanTissue engineering is an approach to the regeneration of tissues that uses a combination of cell sources, signaling factors and scaffolds. Among these three components, signaling factors for bone regeneration have not yet been established, and it is necessary to better understand osteoblast progenitors as a target cells. Several lines of evidence have revealed that, during bone formation, mesenchymal cells are specified and differentiate into osteoblasts through several stages of precursors. The osteoblast lineage is defined by the expression of stage-specific transcription factors. The specification and differentiation are organized by a variety of signaling pathways including hedgehog (Hh), Wnt, Notch, bone morphogenetic protein (BMP) and transforming growth factor-beta (TGFβ). In this review we integrate the known functions of these signaling pathways and discuss future tasks to gain a better understanding of the signaling network in osteogenesis for tissue engineering.http://www.sciencedirect.com/science/article/pii/S2352320414000030Signaling pathwaysOsteoblast lineageSpecification and differentiationTranscription factors |
| spellingShingle | Hironori Hojo Shinsuke Ohba Ung-il Chung Signaling pathways regulating the specification and differentiation of the osteoblast lineage Regenerative Therapy Signaling pathways Osteoblast lineage Specification and differentiation Transcription factors |
| title | Signaling pathways regulating the specification and differentiation of the osteoblast lineage |
| title_full | Signaling pathways regulating the specification and differentiation of the osteoblast lineage |
| title_fullStr | Signaling pathways regulating the specification and differentiation of the osteoblast lineage |
| title_full_unstemmed | Signaling pathways regulating the specification and differentiation of the osteoblast lineage |
| title_short | Signaling pathways regulating the specification and differentiation of the osteoblast lineage |
| title_sort | signaling pathways regulating the specification and differentiation of the osteoblast lineage |
| topic | Signaling pathways Osteoblast lineage Specification and differentiation Transcription factors |
| url | http://www.sciencedirect.com/science/article/pii/S2352320414000030 |
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