The Efficacy of Intravitreal Bevacizumab in Vitreous Hemorrhage of Diabetic Subjects
Objectives: To evaluate the efficacy of intravitreal bevacizumab (IVB) in the resolution of vitreous hemorrhage (VH) secondary to proliferative diabetic retinopathy (PDR). Materials and Methods: Seventy eyes of 70 patients (43 male, mean age 55.6±12.2 years) diagnosed with VH secondary to PDR were...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2016-10-01
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| Series: | Türk Oftalmoloji Dergisi |
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| Online Access: | http://www.oftalmoloji.org/article_11058/The-Efficacy-Of-Intravitreal-Bevacizumab-In-Vitreous-Hemorrhage-Of-Diabetic-Subjects |
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| author | Cengiz Alagöz Yusuf Yıldırım Murat Kocamaz Ökkeş Baz Uğur Çiçek Burcu Çelik Halil İbrahim Demirkale Ahmet Taylan Yazıcı Muhittin Taşkapılı |
| author_facet | Cengiz Alagöz Yusuf Yıldırım Murat Kocamaz Ökkeş Baz Uğur Çiçek Burcu Çelik Halil İbrahim Demirkale Ahmet Taylan Yazıcı Muhittin Taşkapılı |
| author_sort | Cengiz Alagöz |
| collection | DOAJ |
| description | Objectives: To evaluate the efficacy of intravitreal bevacizumab (IVB) in the resolution of vitreous hemorrhage (VH) secondary to proliferative diabetic retinopathy (PDR).
Materials and Methods: Seventy eyes of 70 patients (43 male, mean age 55.6±12.2 years) diagnosed with VH secondary to PDR were evaluated retrospectively. Demographic characteristics of the patients, baseline and final clinical results, and the interventions the patients were subject to were recorded. The patients who received IVB injections (group 1, n=29) were compared to those who did not receive injections (group 2, n=41) in terms of VH clearance time and surgery rates.
Results: The mean follow-up time was 14.5±6.1 months in group 1 and 18.4±9.6 months in group 2 (p=0.185). The mean visual acuity was similar between the groups at baseline and at the last visit (for all p>0.05). Panretinal photocoagulation could be applied in 86% of subjects in group 1 and in 58% in group 2 within the first month (p=0.016). VH clearance time was not different between the groups (2.3±2.1 months in group 1 and 3.4±2.6 months in group 2, p=0.146). The number of subjects requiring surgery was 7 (24%) in group 1 and 20 (48.8%) in group 2 (p=0.048).
Conclusion: IVB was found effective in cases with VH secondary to PDR in terms of reducing the need for surgery and increasing the rate of subjects to whom panretinal photocoagulation could be applied in the early period, although there was no impact on final visual acuity. |
| first_indexed | 2024-04-10T11:35:55Z |
| format | Article |
| id | doaj.art-ea1c00f7714d47c4937fb4682550ea8d |
| institution | Directory Open Access Journal |
| issn | 1300-0659 2147-2661 |
| language | English |
| last_indexed | 2024-04-10T11:35:55Z |
| publishDate | 2016-10-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Oftalmoloji Dergisi |
| spelling | doaj.art-ea1c00f7714d47c4937fb4682550ea8d2023-02-15T16:17:51ZengGalenos YayineviTürk Oftalmoloji Dergisi1300-06592147-26612016-10-0146522122510.4274/tjo.82542The Efficacy of Intravitreal Bevacizumab in Vitreous Hemorrhage of Diabetic SubjectsCengiz Alagöz0Yusuf Yıldırım1Murat Kocamaz2Ökkeş Baz3Uğur Çiçek4Burcu Çelik5Halil İbrahim Demirkale6Ahmet Taylan Yazıcı7Muhittin Taşkapılı8Beyoğlu Eye Training and Research Hospital, İstanbul, TurkeyBeyoğlu Eye Training and Research Hospital, İstanbul, TurkeyBeyoğlu Eye Training and Research Hospital, İstanbul, TurkeyBeyoğlu Eye Training and Research Hospital, İstanbul, TurkeyBeyoğlu Eye Training and Research Hospital, İstanbul, TurkeyBeyoğlu Eye Training and Research Hospital, İstanbul, TurkeyBeyoğlu Eye Training and Research Hospital, İstanbul, TurkeyBeyoğlu Eye Training and Research Hospital, İstanbul, TurkeyBeyoğlu Eye Training and Research Hospital, İstanbul, TurkeyObjectives: To evaluate the efficacy of intravitreal bevacizumab (IVB) in the resolution of vitreous hemorrhage (VH) secondary to proliferative diabetic retinopathy (PDR). Materials and Methods: Seventy eyes of 70 patients (43 male, mean age 55.6±12.2 years) diagnosed with VH secondary to PDR were evaluated retrospectively. Demographic characteristics of the patients, baseline and final clinical results, and the interventions the patients were subject to were recorded. The patients who received IVB injections (group 1, n=29) were compared to those who did not receive injections (group 2, n=41) in terms of VH clearance time and surgery rates. Results: The mean follow-up time was 14.5±6.1 months in group 1 and 18.4±9.6 months in group 2 (p=0.185). The mean visual acuity was similar between the groups at baseline and at the last visit (for all p>0.05). Panretinal photocoagulation could be applied in 86% of subjects in group 1 and in 58% in group 2 within the first month (p=0.016). VH clearance time was not different between the groups (2.3±2.1 months in group 1 and 3.4±2.6 months in group 2, p=0.146). The number of subjects requiring surgery was 7 (24%) in group 1 and 20 (48.8%) in group 2 (p=0.048). Conclusion: IVB was found effective in cases with VH secondary to PDR in terms of reducing the need for surgery and increasing the rate of subjects to whom panretinal photocoagulation could be applied in the early period, although there was no impact on final visual acuity.http://www.oftalmoloji.org/article_11058/The-Efficacy-Of-Intravitreal-Bevacizumab-In-Vitreous-Hemorrhage-Of-Diabetic-SubjectsProliferative diabetic retinopathyvitreous hemorrhageintravitreal bevacizumab |
| spellingShingle | Cengiz Alagöz Yusuf Yıldırım Murat Kocamaz Ökkeş Baz Uğur Çiçek Burcu Çelik Halil İbrahim Demirkale Ahmet Taylan Yazıcı Muhittin Taşkapılı The Efficacy of Intravitreal Bevacizumab in Vitreous Hemorrhage of Diabetic Subjects Türk Oftalmoloji Dergisi Proliferative diabetic retinopathy vitreous hemorrhage intravitreal bevacizumab |
| title | The Efficacy of Intravitreal Bevacizumab in Vitreous Hemorrhage of Diabetic Subjects |
| title_full | The Efficacy of Intravitreal Bevacizumab in Vitreous Hemorrhage of Diabetic Subjects |
| title_fullStr | The Efficacy of Intravitreal Bevacizumab in Vitreous Hemorrhage of Diabetic Subjects |
| title_full_unstemmed | The Efficacy of Intravitreal Bevacizumab in Vitreous Hemorrhage of Diabetic Subjects |
| title_short | The Efficacy of Intravitreal Bevacizumab in Vitreous Hemorrhage of Diabetic Subjects |
| title_sort | efficacy of intravitreal bevacizumab in vitreous hemorrhage of diabetic subjects |
| topic | Proliferative diabetic retinopathy vitreous hemorrhage intravitreal bevacizumab |
| url | http://www.oftalmoloji.org/article_11058/The-Efficacy-Of-Intravitreal-Bevacizumab-In-Vitreous-Hemorrhage-Of-Diabetic-Subjects |
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