The Multi-Scale Impact of the Alzheimer’s Disease on the Topology Diversity of Astrocytes Molecular Communications Nanonetworks
The Internet of Bio-Nano-Things is a new paradigm that can bring novel remotely controlled actuation and sensing techniques inside the human body. Toward precise bionano sensing techniques in the brain, we investigate the challenges of modeling spatial distribution of astrocyte networks by developin...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IEEE
2018-01-01
|
| Series: | IEEE Access |
| Subjects: | |
| Online Access: | https://ieeexplore.ieee.org/document/8573759/ |
| _version_ | 1819163004209463296 |
|---|---|
| author | Michael Taynnan Barros Walisson Silva Carlos Danilo Miranda Regis |
| author_facet | Michael Taynnan Barros Walisson Silva Carlos Danilo Miranda Regis |
| author_sort | Michael Taynnan Barros |
| collection | DOAJ |
| description | The Internet of Bio-Nano-Things is a new paradigm that can bring novel remotely controlled actuation and sensing techniques inside the human body. Toward precise bionano sensing techniques in the brain, we investigate the challenges of modeling spatial distribution of astrocyte networks by developing a mathematical framework that lays the groundwork for future early detection techniques of the neurodegenerative disease. In this paper, we investigate the effect of the β-amyloid plaques in astrocytes with Alzheimer's disease. We developed a computation model of healthy and Alzheimer's diseases astrocytes networks from the state-of-the-art models and results that account for the intracellular pathways, IP3 dynamics, gap junctions, voltage-gated calcium channels, and astrocytes volumes. We also implemented different types of astrocytes network topologies, including shortcut networks, regular degree networks, Erdös Rényi networks, and link radius networks. A proposed multi-scale stochastic computational model captures the relationship between the intracellular and intercellular scales. Finally, we designed and evaluated a singlehop communication system with frequency modulation using metrics such as propagation extend, molecular delay, and channel gain. The results show that the more unstable but at the same time lower level oscillations of Alzheimer's astrocyte networks can create a multi-scale effect on communication between astrocytes with increased molecular delay and lower channel gain compared to healthy astrocytes, with an elevated impact on Erdös Rényi network and link radius network topologies. |
| first_indexed | 2024-12-22T17:37:14Z |
| format | Article |
| id | doaj.art-ea1caafc846140108cca0d23700a43b9 |
| institution | Directory Open Access Journal |
| issn | 2169-3536 |
| language | English |
| last_indexed | 2024-12-22T17:37:14Z |
| publishDate | 2018-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Access |
| spelling | doaj.art-ea1caafc846140108cca0d23700a43b92022-12-21T18:18:30ZengIEEEIEEE Access2169-35362018-01-016789047891710.1109/ACCESS.2018.28855188573759The Multi-Scale Impact of the Alzheimer’s Disease on the Topology Diversity of Astrocytes Molecular Communications NanonetworksMichael Taynnan Barros0https://orcid.org/0000-0002-9765-7660Walisson Silva1Carlos Danilo Miranda Regis2Telecommunication Software and Systems Group, Waterford Institute of Technology, Waterford, IrelandFederal Institute of Education, Science and Technology of Paraíba, João Pessoa, BrazilFederal Institute of Education, Science and Technology of Paraíba, João Pessoa, BrazilThe Internet of Bio-Nano-Things is a new paradigm that can bring novel remotely controlled actuation and sensing techniques inside the human body. Toward precise bionano sensing techniques in the brain, we investigate the challenges of modeling spatial distribution of astrocyte networks by developing a mathematical framework that lays the groundwork for future early detection techniques of the neurodegenerative disease. In this paper, we investigate the effect of the β-amyloid plaques in astrocytes with Alzheimer's disease. We developed a computation model of healthy and Alzheimer's diseases astrocytes networks from the state-of-the-art models and results that account for the intracellular pathways, IP3 dynamics, gap junctions, voltage-gated calcium channels, and astrocytes volumes. We also implemented different types of astrocytes network topologies, including shortcut networks, regular degree networks, Erdös Rényi networks, and link radius networks. A proposed multi-scale stochastic computational model captures the relationship between the intracellular and intercellular scales. Finally, we designed and evaluated a singlehop communication system with frequency modulation using metrics such as propagation extend, molecular delay, and channel gain. The results show that the more unstable but at the same time lower level oscillations of Alzheimer's astrocyte networks can create a multi-scale effect on communication between astrocytes with increased molecular delay and lower channel gain compared to healthy astrocytes, with an elevated impact on Erdös Rényi network and link radius network topologies.https://ieeexplore.ieee.org/document/8573759/Molecular communicationsnanonetworksbionano sensingcommunication theoryAlzheimer’s |
| spellingShingle | Michael Taynnan Barros Walisson Silva Carlos Danilo Miranda Regis The Multi-Scale Impact of the Alzheimer’s Disease on the Topology Diversity of Astrocytes Molecular Communications Nanonetworks IEEE Access Molecular communications nanonetworks bionano sensing communication theory Alzheimer’s |
| title | The Multi-Scale Impact of the Alzheimer’s Disease on the Topology Diversity of Astrocytes Molecular Communications Nanonetworks |
| title_full | The Multi-Scale Impact of the Alzheimer’s Disease on the Topology Diversity of Astrocytes Molecular Communications Nanonetworks |
| title_fullStr | The Multi-Scale Impact of the Alzheimer’s Disease on the Topology Diversity of Astrocytes Molecular Communications Nanonetworks |
| title_full_unstemmed | The Multi-Scale Impact of the Alzheimer’s Disease on the Topology Diversity of Astrocytes Molecular Communications Nanonetworks |
| title_short | The Multi-Scale Impact of the Alzheimer’s Disease on the Topology Diversity of Astrocytes Molecular Communications Nanonetworks |
| title_sort | multi scale impact of the alzheimer x2019 s disease on the topology diversity of astrocytes molecular communications nanonetworks |
| topic | Molecular communications nanonetworks bionano sensing communication theory Alzheimer’s |
| url | https://ieeexplore.ieee.org/document/8573759/ |
| work_keys_str_mv | AT michaeltaynnanbarros themultiscaleimpactofthealzheimerx2019sdiseaseonthetopologydiversityofastrocytesmolecularcommunicationsnanonetworks AT walissonsilva themultiscaleimpactofthealzheimerx2019sdiseaseonthetopologydiversityofastrocytesmolecularcommunicationsnanonetworks AT carlosdanilomirandaregis themultiscaleimpactofthealzheimerx2019sdiseaseonthetopologydiversityofastrocytesmolecularcommunicationsnanonetworks AT michaeltaynnanbarros multiscaleimpactofthealzheimerx2019sdiseaseonthetopologydiversityofastrocytesmolecularcommunicationsnanonetworks AT walissonsilva multiscaleimpactofthealzheimerx2019sdiseaseonthetopologydiversityofastrocytesmolecularcommunicationsnanonetworks AT carlosdanilomirandaregis multiscaleimpactofthealzheimerx2019sdiseaseonthetopologydiversityofastrocytesmolecularcommunicationsnanonetworks |