Small molecules of herbal origin for osteoarthritis treatment: in vitro and in vivo evidence
Abstract Osteoarthritis (OA) is one of the most common musculoskeletal degenerative diseases and contributes to heavy socioeconomic burden. Current pharmacological and conventional non-pharmacological therapies aim at relieving the symptoms like pain and disability rather than modifying the underlyi...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13075-022-02785-y |
| _version_ | 1828220776340258816 |
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| author | Penghui Zhang Kaihu Li Amir Kamali Reihane Ziadlou Paras Ahmad Xinluan Wang R. Geoff Richards Mauro Alini Valentina Basoli Zhen Li Sibylle Grad |
| author_facet | Penghui Zhang Kaihu Li Amir Kamali Reihane Ziadlou Paras Ahmad Xinluan Wang R. Geoff Richards Mauro Alini Valentina Basoli Zhen Li Sibylle Grad |
| author_sort | Penghui Zhang |
| collection | DOAJ |
| description | Abstract Osteoarthritis (OA) is one of the most common musculoskeletal degenerative diseases and contributes to heavy socioeconomic burden. Current pharmacological and conventional non-pharmacological therapies aim at relieving the symptoms like pain and disability rather than modifying the underlying disease. Surgical treatment and ultimately joint replacement arthroplasty are indicated in advanced stages of OA. Since the underlying mechanisms of OA onset and progression have not been fully elucidated yet, the development of novel therapeutics to prevent, halt, or reverse the disease is laborious. Recently, small molecules of herbal origin have been reported to show potent anti-inflammatory, anti-catabolic, and anabolic effects, implying their potential for treatment of OA. Herein, the molecular mechanisms of these small molecules, their effect on physiological or pathological signaling pathways, the advancement of the extraction methods, and their potential clinical translation based on in vitro and in vivo evidence are comprehensively reviewed. |
| first_indexed | 2024-04-12T16:30:35Z |
| format | Article |
| id | doaj.art-ea1e9bae08d64691baf7841e5e594eac |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-04-12T16:30:35Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-ea1e9bae08d64691baf7841e5e594eac2022-12-22T03:25:09ZengBMCArthritis Research & Therapy1478-63622022-05-0124111910.1186/s13075-022-02785-ySmall molecules of herbal origin for osteoarthritis treatment: in vitro and in vivo evidencePenghui Zhang0Kaihu Li1Amir Kamali2Reihane Ziadlou3Paras Ahmad4Xinluan Wang5R. Geoff Richards6Mauro Alini7Valentina Basoli8Zhen Li9Sibylle Grad10AO Research Institute DavosAO Research Institute DavosAO Research Institute DavosAO Research Institute DavosAO Research Institute DavosTranslational Medicine R&D Center, Shenzhen Institute of Advanced Technology, Chinese Academy of SciencesAO Research Institute DavosAO Research Institute DavosAO Research Institute DavosAO Research Institute DavosAO Research Institute DavosAbstract Osteoarthritis (OA) is one of the most common musculoskeletal degenerative diseases and contributes to heavy socioeconomic burden. Current pharmacological and conventional non-pharmacological therapies aim at relieving the symptoms like pain and disability rather than modifying the underlying disease. Surgical treatment and ultimately joint replacement arthroplasty are indicated in advanced stages of OA. Since the underlying mechanisms of OA onset and progression have not been fully elucidated yet, the development of novel therapeutics to prevent, halt, or reverse the disease is laborious. Recently, small molecules of herbal origin have been reported to show potent anti-inflammatory, anti-catabolic, and anabolic effects, implying their potential for treatment of OA. Herein, the molecular mechanisms of these small molecules, their effect on physiological or pathological signaling pathways, the advancement of the extraction methods, and their potential clinical translation based on in vitro and in vivo evidence are comprehensively reviewed.https://doi.org/10.1186/s13075-022-02785-yTraditional Chinese medicineHerbal medicineHerbal extractionTherapeutic targetCompound deliveryInflammation |
| spellingShingle | Penghui Zhang Kaihu Li Amir Kamali Reihane Ziadlou Paras Ahmad Xinluan Wang R. Geoff Richards Mauro Alini Valentina Basoli Zhen Li Sibylle Grad Small molecules of herbal origin for osteoarthritis treatment: in vitro and in vivo evidence Arthritis Research & Therapy Traditional Chinese medicine Herbal medicine Herbal extraction Therapeutic target Compound delivery Inflammation |
| title | Small molecules of herbal origin for osteoarthritis treatment: in vitro and in vivo evidence |
| title_full | Small molecules of herbal origin for osteoarthritis treatment: in vitro and in vivo evidence |
| title_fullStr | Small molecules of herbal origin for osteoarthritis treatment: in vitro and in vivo evidence |
| title_full_unstemmed | Small molecules of herbal origin for osteoarthritis treatment: in vitro and in vivo evidence |
| title_short | Small molecules of herbal origin for osteoarthritis treatment: in vitro and in vivo evidence |
| title_sort | small molecules of herbal origin for osteoarthritis treatment in vitro and in vivo evidence |
| topic | Traditional Chinese medicine Herbal medicine Herbal extraction Therapeutic target Compound delivery Inflammation |
| url | https://doi.org/10.1186/s13075-022-02785-y |
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