A Mendelian randomization investigation of the causal association between the gut microbiota and sleep disorders
BackgroundIncreasing numbers of people are suffering from sleep disorders. The gut microbiota of these individuals differs significantly. However, no reports are available on the causal associations between specific gut microbiota and sleep disorders.MethodsData on gut genera were obtained from the...
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1372827/full |
| _version_ | 1797249313273806848 |
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| author | Wei Yan Zhenzhen Zhuang Yuhao Gao Yuntao Wang Daikun He Daikun He Daikun He |
| author_facet | Wei Yan Zhenzhen Zhuang Yuhao Gao Yuntao Wang Daikun He Daikun He Daikun He |
| author_sort | Wei Yan |
| collection | DOAJ |
| description | BackgroundIncreasing numbers of people are suffering from sleep disorders. The gut microbiota of these individuals differs significantly. However, no reports are available on the causal associations between specific gut microbiota and sleep disorders.MethodsData on gut genera were obtained from the MiBioGen consortium. Twenty-four cohorts with 18,340 individuals of European origin were included. Sleep disorder data, which included 216,454 European individuals, were retrieved from the FinnGen Biobank. Subsequently, two-sample Mendelian randomization was performed to analyze associations between sleep disorders and specific components of the gut microbiota.ResultsInverse variance weighting (IVW) revealed a negative correlation between Coprobacter and sleep disorders (OR = 0.797, 95% CI = 0.66–0.96, and p = 0.016), a positive correlation between Lachnospiraceae and sleep disorders (OR = 1.429, 95% CI = 1.03–1.98, and p = 0.032), a negative association between Oscillospira and sleep disorders (OR = 0.745, 95% CI = 0.56–0.98, and p = 0.038), and a negative association between Peptococcus and sleep disorders (OR = 0.858, 95% CI = 0.74–0.99, p = 0.039).ConclusionA significant causal relationship was found between four specific gut microbiota and sleep disorders. One family, Lachnospiraceae, was observed to increase the risk of sleep disorders, while three genera, namely, Coprobacter, Oscillospira, and Peptococcus, could reduce the risk of sleep disorders. However, further investigations are needed to confirm the specific mechanisms by which the gut microbiota affects sleep. |
| first_indexed | 2024-04-24T20:28:30Z |
| format | Article |
| id | doaj.art-ea1f00a47be9470a91631f9dc56bf814 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-24T20:28:30Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-ea1f00a47be9470a91631f9dc56bf8142024-03-22T04:45:52ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-03-011510.3389/fmicb.2024.13728271372827A Mendelian randomization investigation of the causal association between the gut microbiota and sleep disordersWei Yan0Zhenzhen Zhuang1Yuhao Gao2Yuntao Wang3Daikun He4Daikun He5Daikun He6Department of General Practice, Jinshan Hospital, Fudan University, Shanghai, ChinaDepartment of General Practice, Jinshan Hospital, Fudan University, Shanghai, ChinaDepartment of General Practice, Jinshan Hospital, Fudan University, Shanghai, ChinaDepartment of General Practice, Jinshan Hospital, Fudan University, Shanghai, ChinaDepartment of General Practice, Jinshan Hospital, Fudan University, Shanghai, ChinaDepartment of General Practice, Zhongshan Hospital, Fudan University, Shanghai, ChinaCenter of Emergency and Critical Care Medicine, Jinshan Hospital, Fudan University, Shanghai, ChinaBackgroundIncreasing numbers of people are suffering from sleep disorders. The gut microbiota of these individuals differs significantly. However, no reports are available on the causal associations between specific gut microbiota and sleep disorders.MethodsData on gut genera were obtained from the MiBioGen consortium. Twenty-four cohorts with 18,340 individuals of European origin were included. Sleep disorder data, which included 216,454 European individuals, were retrieved from the FinnGen Biobank. Subsequently, two-sample Mendelian randomization was performed to analyze associations between sleep disorders and specific components of the gut microbiota.ResultsInverse variance weighting (IVW) revealed a negative correlation between Coprobacter and sleep disorders (OR = 0.797, 95% CI = 0.66–0.96, and p = 0.016), a positive correlation between Lachnospiraceae and sleep disorders (OR = 1.429, 95% CI = 1.03–1.98, and p = 0.032), a negative association between Oscillospira and sleep disorders (OR = 0.745, 95% CI = 0.56–0.98, and p = 0.038), and a negative association between Peptococcus and sleep disorders (OR = 0.858, 95% CI = 0.74–0.99, p = 0.039).ConclusionA significant causal relationship was found between four specific gut microbiota and sleep disorders. One family, Lachnospiraceae, was observed to increase the risk of sleep disorders, while three genera, namely, Coprobacter, Oscillospira, and Peptococcus, could reduce the risk of sleep disorders. However, further investigations are needed to confirm the specific mechanisms by which the gut microbiota affects sleep.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1372827/fullcausal associationgut microbiotagut-brain axisMendelian randomizationsleep disorders |
| spellingShingle | Wei Yan Zhenzhen Zhuang Yuhao Gao Yuntao Wang Daikun He Daikun He Daikun He A Mendelian randomization investigation of the causal association between the gut microbiota and sleep disorders Frontiers in Microbiology causal association gut microbiota gut-brain axis Mendelian randomization sleep disorders |
| title | A Mendelian randomization investigation of the causal association between the gut microbiota and sleep disorders |
| title_full | A Mendelian randomization investigation of the causal association between the gut microbiota and sleep disorders |
| title_fullStr | A Mendelian randomization investigation of the causal association between the gut microbiota and sleep disorders |
| title_full_unstemmed | A Mendelian randomization investigation of the causal association between the gut microbiota and sleep disorders |
| title_short | A Mendelian randomization investigation of the causal association between the gut microbiota and sleep disorders |
| title_sort | mendelian randomization investigation of the causal association between the gut microbiota and sleep disorders |
| topic | causal association gut microbiota gut-brain axis Mendelian randomization sleep disorders |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1372827/full |
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