Midkine: The Who, What, Where, and When of a Promising Neurotrophic Therapy for Perinatal Brain Injury

Midkine: The Who, What, Where, and When of a Promising Neurotrophic Therapy for Perinatal Brain Injury

Midkine (MK) is a small secreted heparin-binding protein highly expressed during embryonic/fetal development which, through interactions with multiple cell surface receptors promotes growth through effects on cell proliferation, migration, and differentiation. MK is upregulated in the adult central...

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Bibliographic Details
Main Authors: Emily Ross-Munro, Faith Kwa, Jenny Kreiner, Madhavi Khore, Suzanne L. Miller, Mary Tolcos, Bobbi Fleiss, David W. Walker
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Neurology
Subjects:
midkine
neurotrophins
hypoxia
neuroinflammation
perinatal brain damage
preterm birth
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2020.568814/full

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