New Approaches on the Anti-Inflammatory and Cardioprotective Properties of <i>Taraxacum officinale</i> Tincture
The present research investigated the in vivo anti-inflammatory and cardioprotective activities, as well as the antioxidant potential of <i>Taraxacum officinale</i> tincture (TOT), in relation to the polyphenolic composition. Chromatographic and spectrophotometric techniques were used to...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/16/3/358 |
| _version_ | 1797609605055905792 |
|---|---|
| author | Alexandra Epure Alina E. Pârvu Laurian Vlase Daniela Benedec Daniela Hanganu Ovidiu Oniga Ana-Maria Vlase Irina Ielciu Anca Toiu Ilioara Oniga |
| author_facet | Alexandra Epure Alina E. Pârvu Laurian Vlase Daniela Benedec Daniela Hanganu Ovidiu Oniga Ana-Maria Vlase Irina Ielciu Anca Toiu Ilioara Oniga |
| author_sort | Alexandra Epure |
| collection | DOAJ |
| description | The present research investigated the in vivo anti-inflammatory and cardioprotective activities, as well as the antioxidant potential of <i>Taraxacum officinale</i> tincture (TOT), in relation to the polyphenolic composition. Chromatographic and spectrophotometric techniques were used to determine the polyphenolic profile of TOT and the antioxidant activity was preliminarily assessed in vitro by DPPH• and FRAP spectrophotometric methods. The in vivo anti-inflammatory and cardioprotective activities were studied in rat turpentine-induced inflammation and in rat isoprenaline-induced myocardial infarction (MI) models. The main polyphenolic compound identified in TOT was cichoric acid. The oxidative stress determinations showed the capacity of the dandelion tincture not only to decrease the total oxidative stress (TOS), the oxidative stress index (OSI), and the total antioxidant capacity (TAC), but also the malondialdehide (MDA), thiols (SH), and nitrites/nitrates (NOx) levels both in inflammation and MI models. In addition, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatin kinase-MB (CK-MB), and nuclear factor kappa B (NF-κB) parameters were decreased by the administration of the tincture. The results show that <i>T. officinale</i> could be considered a valuable source of natural compounds with important benefits in pathologies linked to oxidative stress. |
| first_indexed | 2024-03-11T06:03:43Z |
| format | Article |
| id | doaj.art-ea21ca4ade8f4a66ab63ff12c1585d91 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T06:03:43Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-ea21ca4ade8f4a66ab63ff12c1585d912023-11-17T13:11:41ZengMDPI AGPharmaceuticals1424-82472023-02-0116335810.3390/ph16030358New Approaches on the Anti-Inflammatory and Cardioprotective Properties of <i>Taraxacum officinale</i> TinctureAlexandra Epure0Alina E. Pârvu1Laurian Vlase2Daniela Benedec3Daniela Hanganu4Ovidiu Oniga5Ana-Maria Vlase6Irina Ielciu7Anca Toiu8Ilioara Oniga9Department of Pharmacognosy, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 V. Babeș Street, 400012 Cluj-Napoca, RomaniaDepartment of Physiopathology, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 V. Babeș Street, 400012 Cluj-Napoca, RomaniaDepartment of Pharmaceutical Technology and Biopharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 V. Babeș Street, 400012 Cluj-Napoca, RomaniaDepartment of Pharmacognosy, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 V. Babeș Street, 400012 Cluj-Napoca, RomaniaDepartment of Pharmacognosy, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 V. Babeș Street, 400012 Cluj-Napoca, RomaniaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 V. Babeș Street, 400012 Cluj-Napoca, RomaniaDepartment of Pharmaceutical Botany, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 23 Gheorghe Marinescu Street, 400337 Cluj-Napoca, RomaniaDepartment of Pharmaceutical Botany, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 23 Gheorghe Marinescu Street, 400337 Cluj-Napoca, RomaniaDepartment of Pharmacognosy, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 V. Babeș Street, 400012 Cluj-Napoca, RomaniaDepartment of Pharmacognosy, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 V. Babeș Street, 400012 Cluj-Napoca, RomaniaThe present research investigated the in vivo anti-inflammatory and cardioprotective activities, as well as the antioxidant potential of <i>Taraxacum officinale</i> tincture (TOT), in relation to the polyphenolic composition. Chromatographic and spectrophotometric techniques were used to determine the polyphenolic profile of TOT and the antioxidant activity was preliminarily assessed in vitro by DPPH• and FRAP spectrophotometric methods. The in vivo anti-inflammatory and cardioprotective activities were studied in rat turpentine-induced inflammation and in rat isoprenaline-induced myocardial infarction (MI) models. The main polyphenolic compound identified in TOT was cichoric acid. The oxidative stress determinations showed the capacity of the dandelion tincture not only to decrease the total oxidative stress (TOS), the oxidative stress index (OSI), and the total antioxidant capacity (TAC), but also the malondialdehide (MDA), thiols (SH), and nitrites/nitrates (NOx) levels both in inflammation and MI models. In addition, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatin kinase-MB (CK-MB), and nuclear factor kappa B (NF-κB) parameters were decreased by the administration of the tincture. The results show that <i>T. officinale</i> could be considered a valuable source of natural compounds with important benefits in pathologies linked to oxidative stress.https://www.mdpi.com/1424-8247/16/3/358<i>Taraxacum officinale</i>cardioprotectiveanti-inflammatoryantioxidantpolyphenolscichoric acid |
| spellingShingle | Alexandra Epure Alina E. Pârvu Laurian Vlase Daniela Benedec Daniela Hanganu Ovidiu Oniga Ana-Maria Vlase Irina Ielciu Anca Toiu Ilioara Oniga New Approaches on the Anti-Inflammatory and Cardioprotective Properties of <i>Taraxacum officinale</i> Tincture Pharmaceuticals <i>Taraxacum officinale</i> cardioprotective anti-inflammatory antioxidant polyphenols cichoric acid |
| title | New Approaches on the Anti-Inflammatory and Cardioprotective Properties of <i>Taraxacum officinale</i> Tincture |
| title_full | New Approaches on the Anti-Inflammatory and Cardioprotective Properties of <i>Taraxacum officinale</i> Tincture |
| title_fullStr | New Approaches on the Anti-Inflammatory and Cardioprotective Properties of <i>Taraxacum officinale</i> Tincture |
| title_full_unstemmed | New Approaches on the Anti-Inflammatory and Cardioprotective Properties of <i>Taraxacum officinale</i> Tincture |
| title_short | New Approaches on the Anti-Inflammatory and Cardioprotective Properties of <i>Taraxacum officinale</i> Tincture |
| title_sort | new approaches on the anti inflammatory and cardioprotective properties of i taraxacum officinale i tincture |
| topic | <i>Taraxacum officinale</i> cardioprotective anti-inflammatory antioxidant polyphenols cichoric acid |
| url | https://www.mdpi.com/1424-8247/16/3/358 |
| work_keys_str_mv | AT alexandraepure newapproachesontheantiinflammatoryandcardioprotectivepropertiesofitaraxacumofficinaleitincture AT alinaeparvu newapproachesontheantiinflammatoryandcardioprotectivepropertiesofitaraxacumofficinaleitincture AT laurianvlase newapproachesontheantiinflammatoryandcardioprotectivepropertiesofitaraxacumofficinaleitincture AT danielabenedec newapproachesontheantiinflammatoryandcardioprotectivepropertiesofitaraxacumofficinaleitincture AT danielahanganu newapproachesontheantiinflammatoryandcardioprotectivepropertiesofitaraxacumofficinaleitincture AT ovidiuoniga newapproachesontheantiinflammatoryandcardioprotectivepropertiesofitaraxacumofficinaleitincture AT anamariavlase newapproachesontheantiinflammatoryandcardioprotectivepropertiesofitaraxacumofficinaleitincture AT irinaielciu newapproachesontheantiinflammatoryandcardioprotectivepropertiesofitaraxacumofficinaleitincture AT ancatoiu newapproachesontheantiinflammatoryandcardioprotectivepropertiesofitaraxacumofficinaleitincture AT ilioaraoniga newapproachesontheantiinflammatoryandcardioprotectivepropertiesofitaraxacumofficinaleitincture |