Pearl-inspired graphene oxide-collagen microgel with multi-layer mineralization through microarray chips for bone defect repair
Biomineralization of natural polymers in simulated body fluid (SBF) can significantly improve its biocompatibility, osteoconductivity, and osteoinductivity because of the hydroxyapatite (HAp) deposition. Nevertheless, the superficial HAp crystal deposition hamper the deep inorganic ions exchange in...
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Elsevier
2022-06-01
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Series: | Materials Today Bio |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006422001053 |
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author | Chuchao Zhou Chao Luo Shaokai Liu Shangxuan Jiang Xin Liu Jialun Li Xinyue Zhang Xiaoyan Wu Jiaming Sun Zhenxing Wang |
author_facet | Chuchao Zhou Chao Luo Shaokai Liu Shangxuan Jiang Xin Liu Jialun Li Xinyue Zhang Xiaoyan Wu Jiaming Sun Zhenxing Wang |
author_sort | Chuchao Zhou |
collection | DOAJ |
description | Biomineralization of natural polymers in simulated body fluid (SBF) can significantly improve its biocompatibility, osteoconductivity, and osteoinductivity because of the hydroxyapatite (HAp) deposition. Nevertheless, the superficial HAp crystal deposition hamper the deep inorganic ions exchange in porous microgels, thus gradually leading to a nonuniform regeneration effect. Inspired by the pearl forming process, this article uses the microarray chips to fabricate the multi-layer mineralized graphene oxide (GO)-collagen (Col)-hydroxyapatite (HAp) microgel, denoted as MMGCH. These fabricated MMGCH microgels exhibit porous structure and uniform HAp distribution. Furthermore, the suitable microenvironment offered by microgel promotes the time-dependent proliferation and osteogenic differentiation of stem cells, which resulted in upregulated osteogenesis-related genes and proteins, such as alkaline phosphatase, osteocalcin, and collagen-1. Finally, the MMGCH microgels possess favorable bone regeneration capacities both in cranial bone defects and mandibular bone defects via providing a suitable microenvironment for host-derived cells to form new bone tissues. This work presents a biomimetic means aiming to achieve full-thickness and uniform HAp deposition in hydrogel for bone defect repair. |
first_indexed | 2024-04-12T07:59:20Z |
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id | doaj.art-ea223f8fc3b4423c988d38c8d1868a71 |
institution | Directory Open Access Journal |
issn | 2590-0064 |
language | English |
last_indexed | 2024-04-12T07:59:20Z |
publishDate | 2022-06-01 |
publisher | Elsevier |
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series | Materials Today Bio |
spelling | doaj.art-ea223f8fc3b4423c988d38c8d1868a712022-12-22T03:41:23ZengElsevierMaterials Today Bio2590-00642022-06-0115100307Pearl-inspired graphene oxide-collagen microgel with multi-layer mineralization through microarray chips for bone defect repairChuchao Zhou0Chao Luo1Shaokai Liu2Shangxuan Jiang3Xin Liu4Jialun Li5Xinyue Zhang6Xiaoyan Wu7Jiaming Sun8Zhenxing Wang9Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Department of Plastic Surgery, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan, 430060, ChinaDepartment of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, ChinaDepartment of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, ChinaDepartment of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, ChinaDepartment of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, ChinaDepartment of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, ChinaDepartment of Pediatric, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, ChinaDepartment of Pediatric, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, ChinaDepartment of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Corresponding author.Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Corresponding author.Biomineralization of natural polymers in simulated body fluid (SBF) can significantly improve its biocompatibility, osteoconductivity, and osteoinductivity because of the hydroxyapatite (HAp) deposition. Nevertheless, the superficial HAp crystal deposition hamper the deep inorganic ions exchange in porous microgels, thus gradually leading to a nonuniform regeneration effect. Inspired by the pearl forming process, this article uses the microarray chips to fabricate the multi-layer mineralized graphene oxide (GO)-collagen (Col)-hydroxyapatite (HAp) microgel, denoted as MMGCH. These fabricated MMGCH microgels exhibit porous structure and uniform HAp distribution. Furthermore, the suitable microenvironment offered by microgel promotes the time-dependent proliferation and osteogenic differentiation of stem cells, which resulted in upregulated osteogenesis-related genes and proteins, such as alkaline phosphatase, osteocalcin, and collagen-1. Finally, the MMGCH microgels possess favorable bone regeneration capacities both in cranial bone defects and mandibular bone defects via providing a suitable microenvironment for host-derived cells to form new bone tissues. This work presents a biomimetic means aiming to achieve full-thickness and uniform HAp deposition in hydrogel for bone defect repair.http://www.sciencedirect.com/science/article/pii/S2590006422001053Microarry chipGraphene oxideHydroxyapatitePearl-inspiredMulti-layer mineralization |
spellingShingle | Chuchao Zhou Chao Luo Shaokai Liu Shangxuan Jiang Xin Liu Jialun Li Xinyue Zhang Xiaoyan Wu Jiaming Sun Zhenxing Wang Pearl-inspired graphene oxide-collagen microgel with multi-layer mineralization through microarray chips for bone defect repair Materials Today Bio Microarry chip Graphene oxide Hydroxyapatite Pearl-inspired Multi-layer mineralization |
title | Pearl-inspired graphene oxide-collagen microgel with multi-layer mineralization through microarray chips for bone defect repair |
title_full | Pearl-inspired graphene oxide-collagen microgel with multi-layer mineralization through microarray chips for bone defect repair |
title_fullStr | Pearl-inspired graphene oxide-collagen microgel with multi-layer mineralization through microarray chips for bone defect repair |
title_full_unstemmed | Pearl-inspired graphene oxide-collagen microgel with multi-layer mineralization through microarray chips for bone defect repair |
title_short | Pearl-inspired graphene oxide-collagen microgel with multi-layer mineralization through microarray chips for bone defect repair |
title_sort | pearl inspired graphene oxide collagen microgel with multi layer mineralization through microarray chips for bone defect repair |
topic | Microarry chip Graphene oxide Hydroxyapatite Pearl-inspired Multi-layer mineralization |
url | http://www.sciencedirect.com/science/article/pii/S2590006422001053 |
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