Two‐Year Changes in Proteinuria and the Risk of Stroke in the Chinese Population: A Prospective Cohort Study
BackgroundWhether changes in proteinuria are associated with incident stroke in the general population is unclear. This study aimed to investigate the association between changes in proteinuria and incident stroke and its subtypes. Methods and ResultsThe current study included 60 940 Chinese partici...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-07-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.117.006271 |
| _version_ | 1818315078778224640 |
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| author | Anxin Wang Xiaoxue Liu Zhaoping Su Shuohua Chen Nan Zhang Shouling Wu Yongjun Wang Yilong Wang |
| author_facet | Anxin Wang Xiaoxue Liu Zhaoping Su Shuohua Chen Nan Zhang Shouling Wu Yongjun Wang Yilong Wang |
| author_sort | Anxin Wang |
| collection | DOAJ |
| description | BackgroundWhether changes in proteinuria are associated with incident stroke in the general population is unclear. This study aimed to investigate the association between changes in proteinuria and incident stroke and its subtypes. Methods and ResultsThe current study included 60 940 Chinese participants (mean age, 50.69 years) who were free of stroke at the time of surveys (2006–2007 and 2008–2009). Participants were divided into 4 categories according to 2‐year changes in proteinuria: no proteinuria, remittent proteinuria, incident proteinuria, and persistent proteinuria. Cox proportional hazards models were used to calculate hazard ratios and their 95% CIs for stroke. After a median follow‐up period of 6.92 years, 1769 individuals developed stroke. After adjustment for confounding factors, incident proteinuria and persistent proteinuria were associated with increased risk of stroke (hazard ratio, 1.46 [95% CI, 1.26–1.68] and hazard ratio, 1.71 [95% CI, 1.42–2.06], respectively) compared with no proteinuria, which were higher than proteinuria detected at one single point (hazard ratio, 1.25; 95% CI, 1.09–1.43). The effect size for risk of stroke subtypes including ischemic stroke and hemorrhagic stroke was similar. ConclusionsChanges in proteinuria exposure, particularly persistent proteinuria, are more likely to reflect the risk of stroke, compared with proteinuria collected at a single time point in the general population. |
| first_indexed | 2024-12-13T08:59:49Z |
| format | Article |
| id | doaj.art-ea2453d3dad142d5bd856ef375a59687 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-13T08:59:49Z |
| publishDate | 2017-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-ea2453d3dad142d5bd856ef375a596872022-12-21T23:53:11ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802017-07-016710.1161/JAHA.117.006271Two‐Year Changes in Proteinuria and the Risk of Stroke in the Chinese Population: A Prospective Cohort StudyAnxin Wang0Xiaoxue Liu1Zhaoping Su2Shuohua Chen3Nan Zhang4Shouling Wu5Yongjun Wang6Yilong Wang7Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Tangshan People's Hospital, North China University of Science and Technology, Tangshan, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaBackgroundWhether changes in proteinuria are associated with incident stroke in the general population is unclear. This study aimed to investigate the association between changes in proteinuria and incident stroke and its subtypes. Methods and ResultsThe current study included 60 940 Chinese participants (mean age, 50.69 years) who were free of stroke at the time of surveys (2006–2007 and 2008–2009). Participants were divided into 4 categories according to 2‐year changes in proteinuria: no proteinuria, remittent proteinuria, incident proteinuria, and persistent proteinuria. Cox proportional hazards models were used to calculate hazard ratios and their 95% CIs for stroke. After a median follow‐up period of 6.92 years, 1769 individuals developed stroke. After adjustment for confounding factors, incident proteinuria and persistent proteinuria were associated with increased risk of stroke (hazard ratio, 1.46 [95% CI, 1.26–1.68] and hazard ratio, 1.71 [95% CI, 1.42–2.06], respectively) compared with no proteinuria, which were higher than proteinuria detected at one single point (hazard ratio, 1.25; 95% CI, 1.09–1.43). The effect size for risk of stroke subtypes including ischemic stroke and hemorrhagic stroke was similar. ConclusionsChanges in proteinuria exposure, particularly persistent proteinuria, are more likely to reflect the risk of stroke, compared with proteinuria collected at a single time point in the general population.https://www.ahajournals.org/doi/10.1161/JAHA.117.006271change in proteinuriacohort studyhemorrhageischemic strokeproteinuria |
| spellingShingle | Anxin Wang Xiaoxue Liu Zhaoping Su Shuohua Chen Nan Zhang Shouling Wu Yongjun Wang Yilong Wang Two‐Year Changes in Proteinuria and the Risk of Stroke in the Chinese Population: A Prospective Cohort Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease change in proteinuria cohort study hemorrhage ischemic stroke proteinuria |
| title | Two‐Year Changes in Proteinuria and the Risk of Stroke in the Chinese Population: A Prospective Cohort Study |
| title_full | Two‐Year Changes in Proteinuria and the Risk of Stroke in the Chinese Population: A Prospective Cohort Study |
| title_fullStr | Two‐Year Changes in Proteinuria and the Risk of Stroke in the Chinese Population: A Prospective Cohort Study |
| title_full_unstemmed | Two‐Year Changes in Proteinuria and the Risk of Stroke in the Chinese Population: A Prospective Cohort Study |
| title_short | Two‐Year Changes in Proteinuria and the Risk of Stroke in the Chinese Population: A Prospective Cohort Study |
| title_sort | two year changes in proteinuria and the risk of stroke in the chinese population a prospective cohort study |
| topic | change in proteinuria cohort study hemorrhage ischemic stroke proteinuria |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.117.006271 |
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