In Vitro Innervation as an Experimental Model to Study the Expression and Functions of Acetylcholinesterase and Agrin in Human Skeletal Muscle

In Vitro Innervation as an Experimental Model to Study the Expression and Functions of Acetylcholinesterase and Agrin in Human Skeletal Muscle

Acetylcholinesterase (AChE) and agrin, a heparan-sulfate proteoglycan, reside in the basal lamina of the neuromuscular junction (NMJ) and play key roles in cholinergic transmission and synaptogenesis. Unlike most NMJ components, AChE and agrin are expressed in skeletal muscle and α-motor neurons. AC...

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Bibliographic Details
Main Authors: Katarina Mis, Zoran Grubic, Paola Lorenzon, Marina Sciancalepore, Tomaz Mars, Sergej Pirkmajer
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Molecules
Subjects:
acetylcholinesterase
in vitro innervation
human muscle
neuromuscular junction
co-cultures
agrin
apoptosis
Online Access:https://www.mdpi.com/1420-3049/22/9/1418

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