Systematic review of cardiovascular neurocristopathy—contemporary insights and future perspectives
IntroductionNeural crest cells (NCCs) are multipotent and are attributed to the combination of complex multimodal gene regulatory mechanisms. Cardiac neural crest (CNC) cells, originating from the dorsal neural tube, are pivotal architects of the cardio-neuro-vascular domain, which orchestrates the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1333265/full |
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| author | Osama Soliman Osama Soliman Yogesh Acharya Yogesh Acharya Martine Gilard Martine Gilard Garry Duffy Garry Duffy William Wijns William Wijns Venkatesh Kannan Venkatesh Kannan Sherif Sultan Sherif Sultan Sherif Sultan |
| author_facet | Osama Soliman Osama Soliman Yogesh Acharya Yogesh Acharya Martine Gilard Martine Gilard Garry Duffy Garry Duffy William Wijns William Wijns Venkatesh Kannan Venkatesh Kannan Sherif Sultan Sherif Sultan Sherif Sultan |
| author_sort | Osama Soliman |
| collection | DOAJ |
| description | IntroductionNeural crest cells (NCCs) are multipotent and are attributed to the combination of complex multimodal gene regulatory mechanisms. Cardiac neural crest (CNC) cells, originating from the dorsal neural tube, are pivotal architects of the cardio-neuro-vascular domain, which orchestrates the embryogenesis of critical cardiac and vascular structures. Remarkably, while the scientific community compiled a comprehensive inventory of neural crest derivatives by the early 1980s, our understanding of the CNC's role in various cardiovascular disease processes still needs to be explored. This review delves into the differentiation of NCC, specifically the CNC cells, and explores the diverse facets of non-syndromic cardiovascular neurocristopathies.MethodsA systematic review was conducted as per the PRISMA Statement. Three prominent databases, PubMed, Scopus, and Embase, were searched, which yielded 1,840 studies. We excluded 1,796 studies, and the final selection of 44 studies formed the basis of this comprehensive review.ResultsNeurocristopathies are a group of genetic disorders that affect the development of cells derived from the NC. Cardiovascular neurocristopathy, i.e., cardiopathy and vasculopathy, associated with the NCC could occur in the form of (1) cardiac septation disorders, mainly the aortico-pulmonary septum; (2) great vessels and vascular disorders; (3) myocardial dysfunction; and (4) a combination of all three phenotypes. This could result from abnormalities in NCC migration, differentiation, or proliferation leading to structural abnormalities and are attributed to genetic, familial, sporadic or acquired causes.DiscussionPhenotypic characteristics of cardiovascular neurocristopathies, such as bicuspid aortic valve and thoracic aortic aneurysm, share a common embryonic origin and are surprisingly prevalent in the general population, necessitating further research to identify the underlying pathogenic and genetic factors responsible for these cardiac anomalies. Such discoveries are essential for enhancing diagnostic screening and refining therapeutic interventions, ultimately improving the lives of individuals affected by these conditions. |
| first_indexed | 2024-04-24T11:31:31Z |
| format | Article |
| id | doaj.art-ea26a7fefed143498b2ef5d799528cf1 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-24T11:31:31Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-ea26a7fefed143498b2ef5d799528cf12024-04-10T10:21:06ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-04-011110.3389/fcvm.2024.13332651333265Systematic review of cardiovascular neurocristopathy—contemporary insights and future perspectivesOsama Soliman0Osama Soliman1Yogesh Acharya2Yogesh Acharya3Martine Gilard4Martine Gilard5Garry Duffy6Garry Duffy7William Wijns8William Wijns9Venkatesh Kannan10Venkatesh Kannan11Sherif Sultan12Sherif Sultan13Sherif Sultan14Department of Cardiology, Galway University Hospital, Galway, IrelandCORRIB-CURAM-Vascular Group Collaborators, University of Galway, Galway, IrelandCORRIB-CURAM-Vascular Group Collaborators, University of Galway, Galway, IrelandWestern Vascular Institute, Department of Vascular and Endovascular Surgery, University Hospital Galway, University of Galway, Galway, IrelandCORRIB-CURAM-Vascular Group Collaborators, University of Galway, Galway, IrelandDepartment of Cardiology, La Cavale Blanche Hospital, Brest, FranceCORRIB-CURAM-Vascular Group Collaborators, University of Galway, Galway, IrelandAnatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, University of Galway, Galway, IrelandDepartment of Cardiology, Galway University Hospital, Galway, IrelandCORRIB-CURAM-Vascular Group Collaborators, University of Galway, Galway, IrelandCORRIB-CURAM-Vascular Group Collaborators, University of Galway, Galway, IrelandIrish Centre for High-End Computing (ICHEC), University of Galway, Galway, IrelandCORRIB-CURAM-Vascular Group Collaborators, University of Galway, Galway, IrelandWestern Vascular Institute, Department of Vascular and Endovascular Surgery, University Hospital Galway, University of Galway, Galway, IrelandDepartment of Vascular Surgery and Endovascular Surgery, Galway Clinic, Doughiska, Royal College of Surgeons in Ireland and University of Galway Affiliated Hospital, Galway, IrelandIntroductionNeural crest cells (NCCs) are multipotent and are attributed to the combination of complex multimodal gene regulatory mechanisms. Cardiac neural crest (CNC) cells, originating from the dorsal neural tube, are pivotal architects of the cardio-neuro-vascular domain, which orchestrates the embryogenesis of critical cardiac and vascular structures. Remarkably, while the scientific community compiled a comprehensive inventory of neural crest derivatives by the early 1980s, our understanding of the CNC's role in various cardiovascular disease processes still needs to be explored. This review delves into the differentiation of NCC, specifically the CNC cells, and explores the diverse facets of non-syndromic cardiovascular neurocristopathies.MethodsA systematic review was conducted as per the PRISMA Statement. Three prominent databases, PubMed, Scopus, and Embase, were searched, which yielded 1,840 studies. We excluded 1,796 studies, and the final selection of 44 studies formed the basis of this comprehensive review.ResultsNeurocristopathies are a group of genetic disorders that affect the development of cells derived from the NC. Cardiovascular neurocristopathy, i.e., cardiopathy and vasculopathy, associated with the NCC could occur in the form of (1) cardiac septation disorders, mainly the aortico-pulmonary septum; (2) great vessels and vascular disorders; (3) myocardial dysfunction; and (4) a combination of all three phenotypes. This could result from abnormalities in NCC migration, differentiation, or proliferation leading to structural abnormalities and are attributed to genetic, familial, sporadic or acquired causes.DiscussionPhenotypic characteristics of cardiovascular neurocristopathies, such as bicuspid aortic valve and thoracic aortic aneurysm, share a common embryonic origin and are surprisingly prevalent in the general population, necessitating further research to identify the underlying pathogenic and genetic factors responsible for these cardiac anomalies. Such discoveries are essential for enhancing diagnostic screening and refining therapeutic interventions, ultimately improving the lives of individuals affected by these conditions.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1333265/fullneural crest cellscardiac neural crest cellscardiovascular neurocristopathycardiac neurocristopathyvascular neurocristopathyaortopathy |
| spellingShingle | Osama Soliman Osama Soliman Yogesh Acharya Yogesh Acharya Martine Gilard Martine Gilard Garry Duffy Garry Duffy William Wijns William Wijns Venkatesh Kannan Venkatesh Kannan Sherif Sultan Sherif Sultan Sherif Sultan Systematic review of cardiovascular neurocristopathy—contemporary insights and future perspectives Frontiers in Cardiovascular Medicine neural crest cells cardiac neural crest cells cardiovascular neurocristopathy cardiac neurocristopathy vascular neurocristopathy aortopathy |
| title | Systematic review of cardiovascular neurocristopathy—contemporary insights and future perspectives |
| title_full | Systematic review of cardiovascular neurocristopathy—contemporary insights and future perspectives |
| title_fullStr | Systematic review of cardiovascular neurocristopathy—contemporary insights and future perspectives |
| title_full_unstemmed | Systematic review of cardiovascular neurocristopathy—contemporary insights and future perspectives |
| title_short | Systematic review of cardiovascular neurocristopathy—contemporary insights and future perspectives |
| title_sort | systematic review of cardiovascular neurocristopathy contemporary insights and future perspectives |
| topic | neural crest cells cardiac neural crest cells cardiovascular neurocristopathy cardiac neurocristopathy vascular neurocristopathy aortopathy |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1333265/full |
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