Ten SNPs May Affect Type 2 Diabetes Risk in Interaction with Prenatal Exposure to Chinese Famine
Increasing studies have demonstrated that gene and famine may interact on type 2 diabetes risk. The data derived from the cross-sectional 2010–2012 China National Nutrition and Health Survey (CNNHS) was examined to explore whether gene and famine interacted to influence type 2 diabetes risk. In tota...
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MDPI AG
2020-12-01
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| Online Access: | https://www.mdpi.com/2072-6643/12/12/3880 |
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| author | Chao Song Caicui Ding Fan Yuan Ganyu Feng Yanning Ma Ailing Liu |
| author_facet | Chao Song Caicui Ding Fan Yuan Ganyu Feng Yanning Ma Ailing Liu |
| author_sort | Chao Song |
| collection | DOAJ |
| description | Increasing studies have demonstrated that gene and famine may interact on type 2 diabetes risk. The data derived from the cross-sectional 2010–2012 China National Nutrition and Health Survey (CNNHS) was examined to explore whether gene and famine interacted to influence type 2 diabetes risk. In total, 2216 subjects were involved. The subjects born in 1960 and 1961 were selected as the famine-exposed group, whereas subjects born in 1963 were selected as the unexposed group. A Mass Array system was used to detect the genotypes of 50 related single-nucleotide polymorphisms (SNPs). Interactions were found between prenatal exposure to famine and ten SNPs (rs10401969, rs10886471, rs10946398, rs1470579, rs2796441, rs340874, rs3794991, rs5015480, rs7961581, and rs9470794) on type 2 diabetes risk after adjustments. The stratified results showed that famine exposure exacerbated the effect of CILP2-rs10401969 to fasting serum insulin (FINS), GRK5-rs10886471 to fasting plasma glucose (FPG) and FINS, IGF2BP2-rs1470579 to FINS, TLE1-rs2796441 to impaired fasting glucose (IFG), PROX1-rs340874 to impaired glucose tolerance (IGT), GATAD2A-rs3794991 to FINS, TSPAN8/LGR5-rs7961581 to FPG, and ZFAND3-rs9470794 to IGT and FINS. Famine exposure weakened the effect of CDKAL1-rs10946398 to type 2 diabetes. Famine exposure weakened the effect of HHEX-rs5015480 to IFG, but exacerbated the effect of HHEX-rs5015480 to FINS. The present study suggests that ten SNPs may affect type 2 diabetes risk in interaction with prenatal exposure to Chinese famine. |
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| spelling | doaj.art-ea2964e351ba4634a80e1c2da0541feb2023-11-21T01:30:12ZengMDPI AGNutrients2072-66432020-12-011212388010.3390/nu12123880Ten SNPs May Affect Type 2 Diabetes Risk in Interaction with Prenatal Exposure to Chinese FamineChao Song0Caicui Ding1Fan Yuan2Ganyu Feng3Yanning Ma4Ailing Liu5National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, ChinaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, ChinaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, ChinaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, ChinaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, ChinaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, ChinaIncreasing studies have demonstrated that gene and famine may interact on type 2 diabetes risk. The data derived from the cross-sectional 2010–2012 China National Nutrition and Health Survey (CNNHS) was examined to explore whether gene and famine interacted to influence type 2 diabetes risk. In total, 2216 subjects were involved. The subjects born in 1960 and 1961 were selected as the famine-exposed group, whereas subjects born in 1963 were selected as the unexposed group. A Mass Array system was used to detect the genotypes of 50 related single-nucleotide polymorphisms (SNPs). Interactions were found between prenatal exposure to famine and ten SNPs (rs10401969, rs10886471, rs10946398, rs1470579, rs2796441, rs340874, rs3794991, rs5015480, rs7961581, and rs9470794) on type 2 diabetes risk after adjustments. The stratified results showed that famine exposure exacerbated the effect of CILP2-rs10401969 to fasting serum insulin (FINS), GRK5-rs10886471 to fasting plasma glucose (FPG) and FINS, IGF2BP2-rs1470579 to FINS, TLE1-rs2796441 to impaired fasting glucose (IFG), PROX1-rs340874 to impaired glucose tolerance (IGT), GATAD2A-rs3794991 to FINS, TSPAN8/LGR5-rs7961581 to FPG, and ZFAND3-rs9470794 to IGT and FINS. Famine exposure weakened the effect of CDKAL1-rs10946398 to type 2 diabetes. Famine exposure weakened the effect of HHEX-rs5015480 to IFG, but exacerbated the effect of HHEX-rs5015480 to FINS. The present study suggests that ten SNPs may affect type 2 diabetes risk in interaction with prenatal exposure to Chinese famine.https://www.mdpi.com/2072-6643/12/12/3880diabetesfamineinteractionprenatal period |
| spellingShingle | Chao Song Caicui Ding Fan Yuan Ganyu Feng Yanning Ma Ailing Liu Ten SNPs May Affect Type 2 Diabetes Risk in Interaction with Prenatal Exposure to Chinese Famine Nutrients diabetes famine interaction prenatal period |
| title | Ten SNPs May Affect Type 2 Diabetes Risk in Interaction with Prenatal Exposure to Chinese Famine |
| title_full | Ten SNPs May Affect Type 2 Diabetes Risk in Interaction with Prenatal Exposure to Chinese Famine |
| title_fullStr | Ten SNPs May Affect Type 2 Diabetes Risk in Interaction with Prenatal Exposure to Chinese Famine |
| title_full_unstemmed | Ten SNPs May Affect Type 2 Diabetes Risk in Interaction with Prenatal Exposure to Chinese Famine |
| title_short | Ten SNPs May Affect Type 2 Diabetes Risk in Interaction with Prenatal Exposure to Chinese Famine |
| title_sort | ten snps may affect type 2 diabetes risk in interaction with prenatal exposure to chinese famine |
| topic | diabetes famine interaction prenatal period |
| url | https://www.mdpi.com/2072-6643/12/12/3880 |
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