Routine Cerebrospinal Fluid (CSF) Parameters in Patients With Spinal Muscular Atrophy (SMA) Treated With Nusinersen

Routine Cerebrospinal Fluid (CSF) Parameters in Patients With Spinal Muscular Atrophy (SMA) Treated With Nusinersen

Background: Nusinersen is an antisense-oligonucleotide (ASO) approved for treatment of 5q-spinal muscular atrophy (SMA). Since the drug cannot cross the blood-brain barrier (BBB), it must be administered into the cerebrospinal fluid (CSF) space repeatedly by lumbar puncture. However, little is known...

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Bibliographic Details
Main Authors: Claudia D. Wurster, Jan C. Koch, Isabell Cordts, Jens Dreyhaupt, Markus Otto, Zeljko Uzelac, Simon Witzel, Benedikt Winter, Tugrul Kocak, Michael Schocke, Patrick Weydt, Kurt Wollinsky, Albert C. Ludolph, Marcus Deschauer, Paul Lingor, Hayrettin Tumani, Andreas Hermann, René Günther
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Neurology
Subjects:
spinal muscular atrophy
motor neuron disease
antisense-oligonucleotide
routine CSF parameters
lumbar puncture
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.01179/full

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