GDF8 Contributes to Liver Fibrogenesis and Concomitant Skeletal Muscle Wasting

GDF8 Contributes to Liver Fibrogenesis and Concomitant Skeletal Muscle Wasting

Patients with end-stage liver disease exhibit progressive skeletal muscle atrophy, highlighting a negative crosstalk between the injured liver and muscle. Our study was to determine whether TGFβ ligands function as the mediators. Acute or chronic liver injury was induced by a single or repeated admi...

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Bibliographic Details
Main Authors: Alexander Culver, Matthew Hamang, Yan Wang, Huaizhou Jiang, Jennifer Yanum, Emily White, Samer Gawrieh, Raj K. Vuppalanchi, Naga P. Chalasani, Guoli Dai, Benjamin C. Yaden
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Biomedicines
Subjects:
liver injury
muscle atrophy
TGFβ family
Gdf8
liver–muscle crosstalk
Online Access:https://www.mdpi.com/2227-9059/11/7/1909

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