Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness
Skeletal muscle wasting in the intensive care unit (ICU) has been associated with mortality, but it is unclear whether sarcopenia, defined by skeletal muscle mass and function, is useful for detailed risk stratification after ICU discharge. In this cohort study, 72 critically ill patients with an IC...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/8/2726 |
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| author | Naoya Yanagi Tomotaka Koike Kentaro Kamiya Nobuaki Hamazaki Kohei Nozaki Takafumi Ichikawa Atsuhiko Matsunaga Masayuki Kuroiwa Masayasu Arai |
| author_facet | Naoya Yanagi Tomotaka Koike Kentaro Kamiya Nobuaki Hamazaki Kohei Nozaki Takafumi Ichikawa Atsuhiko Matsunaga Masayuki Kuroiwa Masayasu Arai |
| author_sort | Naoya Yanagi |
| collection | DOAJ |
| description | Skeletal muscle wasting in the intensive care unit (ICU) has been associated with mortality, but it is unclear whether sarcopenia, defined by skeletal muscle mass and function, is useful for detailed risk stratification after ICU discharge. In this cohort study, 72 critically ill patients with an ICU stay of ≥48 h were identified. Skeletal muscle mass was assessed from the muscle thickness (MT) of the patients’ quadriceps using ultrasound images before ICU discharge. Skeletal muscle function was assessed from the patients’ muscle strength (MS) before ICU discharge according to the Medical Research Council sum score. A diagnosis of sarcopenia in the ICU was made in patients with low MT and low MS. The study endpoint was 1-year mortality. Sarcopenia in the ICU was diagnosed in 26/72 patients (36%). After adjusting for covariates in the Cox regression, sarcopenia in the ICU was significantly associated with 1-year mortality (hazard ratio 3.82; 95% confidence interval, 1.40–10.42). Sarcopenia in the ICU, defined by low skeletal muscle mass and function, was associated with 1-year mortality in survivors of critical illness. Skeletal muscle mass and function assessed at the bedside could be used to identify higher-risk patients in the ICU. |
| first_indexed | 2024-03-10T08:30:44Z |
| format | Article |
| id | doaj.art-ea2bb26a4d904b00819574eaca05f214 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T08:30:44Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-ea2bb26a4d904b00819574eaca05f2142023-11-22T09:05:11ZengMDPI AGNutrients2072-66432021-08-01138272610.3390/nu13082726Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical IllnessNaoya Yanagi0Tomotaka Koike1Kentaro Kamiya2Nobuaki Hamazaki3Kohei Nozaki4Takafumi Ichikawa5Atsuhiko Matsunaga6Masayuki Kuroiwa7Masayasu Arai8Department of Rehabilitation Sciences, Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, JapanDepartment of Intensive Care Center, Kitasato University Hospital, Sagamihara 252-0329, JapanDepartment of Rehabilitation, School of Allied Health Sciences, Kitasato University, Sagamihara 252-0373, JapanDepartment of Rehabilitation, Kitasato University Hospital, Sagamihara 252-0329, JapanDepartment of Rehabilitation, Kitasato University Hospital, Sagamihara 252-0329, JapanDepartment of Rehabilitation, Kitasato University Hospital, Sagamihara 252-0329, JapanDepartment of Rehabilitation, School of Allied Health Sciences, Kitasato University, Sagamihara 252-0373, JapanDepartment of Anesthesiology, School of Medicine, Kitasato University, Sagamihara 252-0373, JapanDivision of Intensive Care Medicine, Department of Research and Development Center for New Medical Frontiers, School of Medicine, Kitasato University, Sagamihara 252-0373, JapanSkeletal muscle wasting in the intensive care unit (ICU) has been associated with mortality, but it is unclear whether sarcopenia, defined by skeletal muscle mass and function, is useful for detailed risk stratification after ICU discharge. In this cohort study, 72 critically ill patients with an ICU stay of ≥48 h were identified. Skeletal muscle mass was assessed from the muscle thickness (MT) of the patients’ quadriceps using ultrasound images before ICU discharge. Skeletal muscle function was assessed from the patients’ muscle strength (MS) before ICU discharge according to the Medical Research Council sum score. A diagnosis of sarcopenia in the ICU was made in patients with low MT and low MS. The study endpoint was 1-year mortality. Sarcopenia in the ICU was diagnosed in 26/72 patients (36%). After adjusting for covariates in the Cox regression, sarcopenia in the ICU was significantly associated with 1-year mortality (hazard ratio 3.82; 95% confidence interval, 1.40–10.42). Sarcopenia in the ICU, defined by low skeletal muscle mass and function, was associated with 1-year mortality in survivors of critical illness. Skeletal muscle mass and function assessed at the bedside could be used to identify higher-risk patients in the ICU.https://www.mdpi.com/2072-6643/13/8/2726critical illnesssarcopeniaskeletal muscle massskeletal muscle functionultrasound |
| spellingShingle | Naoya Yanagi Tomotaka Koike Kentaro Kamiya Nobuaki Hamazaki Kohei Nozaki Takafumi Ichikawa Atsuhiko Matsunaga Masayuki Kuroiwa Masayasu Arai Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness Nutrients critical illness sarcopenia skeletal muscle mass skeletal muscle function ultrasound |
| title | Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness |
| title_full | Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness |
| title_fullStr | Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness |
| title_full_unstemmed | Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness |
| title_short | Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness |
| title_sort | assessment of sarcopenia in the intensive care unit and 1 year mortality in survivors of critical illness |
| topic | critical illness sarcopenia skeletal muscle mass skeletal muscle function ultrasound |
| url | https://www.mdpi.com/2072-6643/13/8/2726 |
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