Signaling Pathway Mediating Myeloma Cell Growth and Survival
The multiple myeloma (MM) bone marrow (BM) microenvironment consists of different types of accessory cells. Both soluble factors (i.e., cytokines) secreted from these cells and adhesion of MM cells to these cells play crucial roles in activation of intracellular signaling pathways mediating MM cell...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/2/216 |
| _version_ | 1797414211502997504 |
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| author | Teru Hideshima Kenneth C. Anderson |
| author_facet | Teru Hideshima Kenneth C. Anderson |
| author_sort | Teru Hideshima |
| collection | DOAJ |
| description | The multiple myeloma (MM) bone marrow (BM) microenvironment consists of different types of accessory cells. Both soluble factors (i.e., cytokines) secreted from these cells and adhesion of MM cells to these cells play crucial roles in activation of intracellular signaling pathways mediating MM cell growth, survival, migration, and drug resistance. Importantly, there is crosstalk between the signaling pathways, increasing the complexity of signal transduction networks in MM cells in the BM microenvironment, highlighting the requirement for combination treatment strategies to blocking multiple signaling pathways. |
| first_indexed | 2024-03-09T05:29:47Z |
| format | Article |
| id | doaj.art-ea2bd53f10344f919954ea3969a28fd5 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T05:29:47Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ea2bd53f10344f919954ea3969a28fd52023-12-03T12:33:46ZengMDPI AGCancers2072-66942021-01-0113221610.3390/cancers13020216Signaling Pathway Mediating Myeloma Cell Growth and SurvivalTeru Hideshima0Kenneth C. Anderson1Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02446, USAJerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02446, USAThe multiple myeloma (MM) bone marrow (BM) microenvironment consists of different types of accessory cells. Both soluble factors (i.e., cytokines) secreted from these cells and adhesion of MM cells to these cells play crucial roles in activation of intracellular signaling pathways mediating MM cell growth, survival, migration, and drug resistance. Importantly, there is crosstalk between the signaling pathways, increasing the complexity of signal transduction networks in MM cells in the BM microenvironment, highlighting the requirement for combination treatment strategies to blocking multiple signaling pathways.https://www.mdpi.com/2072-6694/13/2/216multiple myelomabone marrow microenvironmentcytokinecell adhesionsignal transduction |
| spellingShingle | Teru Hideshima Kenneth C. Anderson Signaling Pathway Mediating Myeloma Cell Growth and Survival Cancers multiple myeloma bone marrow microenvironment cytokine cell adhesion signal transduction |
| title | Signaling Pathway Mediating Myeloma Cell Growth and Survival |
| title_full | Signaling Pathway Mediating Myeloma Cell Growth and Survival |
| title_fullStr | Signaling Pathway Mediating Myeloma Cell Growth and Survival |
| title_full_unstemmed | Signaling Pathway Mediating Myeloma Cell Growth and Survival |
| title_short | Signaling Pathway Mediating Myeloma Cell Growth and Survival |
| title_sort | signaling pathway mediating myeloma cell growth and survival |
| topic | multiple myeloma bone marrow microenvironment cytokine cell adhesion signal transduction |
| url | https://www.mdpi.com/2072-6694/13/2/216 |
| work_keys_str_mv | AT teruhideshima signalingpathwaymediatingmyelomacellgrowthandsurvival AT kennethcanderson signalingpathwaymediatingmyelomacellgrowthandsurvival |