The association between renal accumulation of pancreatic amyloid-forming amylin and renal hypoxia
Chronic kidney disease (CKD) is increasing worldwide and is associated with diabetic states (obesity, prediabetes and type-2 diabetes mellitus). The kidney is intrinsically susceptible to low oxygen (hypoxia) and renal hypoxia plays a vital role in the progression of CKD. Recent studies suggest an a...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1104662/full |
| _version_ | 1797904878428749824 |
|---|---|
| author | Nirmal Verma Florin Despa |
| author_facet | Nirmal Verma Florin Despa |
| author_sort | Nirmal Verma |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is increasing worldwide and is associated with diabetic states (obesity, prediabetes and type-2 diabetes mellitus). The kidney is intrinsically susceptible to low oxygen (hypoxia) and renal hypoxia plays a vital role in the progression of CKD. Recent studies suggest an association between CKD and renal deposition of amyloid-forming amylin secreted from the pancreas. Renal accumulation of amyloid-forming amylin is associated with hypertension, mitochondrial dysfunction, increased production of reactive oxygen species (ROS) and activation of hypoxia signaling in the kidney. In this review we will discuss potential associations between renal amylin amyloid accumulation, hypertension, and mechanism of hypoxia-induced kidney dysfunction, including activation of hypoxia-inducible factors (HIFs) and mitochondrial dysfunction. |
| first_indexed | 2024-04-10T09:55:56Z |
| format | Article |
| id | doaj.art-ea2bf78fbfee4656858a4d32290dd5c6 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T09:55:56Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-ea2bf78fbfee4656858a4d32290dd5c62023-02-16T12:30:24ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-02-011410.3389/fendo.2023.11046621104662The association between renal accumulation of pancreatic amyloid-forming amylin and renal hypoxiaNirmal VermaFlorin DespaChronic kidney disease (CKD) is increasing worldwide and is associated with diabetic states (obesity, prediabetes and type-2 diabetes mellitus). The kidney is intrinsically susceptible to low oxygen (hypoxia) and renal hypoxia plays a vital role in the progression of CKD. Recent studies suggest an association between CKD and renal deposition of amyloid-forming amylin secreted from the pancreas. Renal accumulation of amyloid-forming amylin is associated with hypertension, mitochondrial dysfunction, increased production of reactive oxygen species (ROS) and activation of hypoxia signaling in the kidney. In this review we will discuss potential associations between renal amylin amyloid accumulation, hypertension, and mechanism of hypoxia-induced kidney dysfunction, including activation of hypoxia-inducible factors (HIFs) and mitochondrial dysfunction.https://www.frontiersin.org/articles/10.3389/fendo.2023.1104662/fullkidney diseasemitochondriareactive oxygen specieshypoxiaamylin |
| spellingShingle | Nirmal Verma Florin Despa The association between renal accumulation of pancreatic amyloid-forming amylin and renal hypoxia Frontiers in Endocrinology kidney disease mitochondria reactive oxygen species hypoxia amylin |
| title | The association between renal accumulation of pancreatic amyloid-forming amylin and renal hypoxia |
| title_full | The association between renal accumulation of pancreatic amyloid-forming amylin and renal hypoxia |
| title_fullStr | The association between renal accumulation of pancreatic amyloid-forming amylin and renal hypoxia |
| title_full_unstemmed | The association between renal accumulation of pancreatic amyloid-forming amylin and renal hypoxia |
| title_short | The association between renal accumulation of pancreatic amyloid-forming amylin and renal hypoxia |
| title_sort | association between renal accumulation of pancreatic amyloid forming amylin and renal hypoxia |
| topic | kidney disease mitochondria reactive oxygen species hypoxia amylin |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1104662/full |
| work_keys_str_mv | AT nirmalverma theassociationbetweenrenalaccumulationofpancreaticamyloidformingamylinandrenalhypoxia AT florindespa theassociationbetweenrenalaccumulationofpancreaticamyloidformingamylinandrenalhypoxia AT nirmalverma associationbetweenrenalaccumulationofpancreaticamyloidformingamylinandrenalhypoxia AT florindespa associationbetweenrenalaccumulationofpancreaticamyloidformingamylinandrenalhypoxia |