SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication
To ensure genome stability, cells need to restrict DNA replication to once per cell cycle. Here the authors show that Cyclin F interacts with and targets the licensing factor CDC6 for degradation, preventing re-firing of replication origins.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2016-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10530 |
| _version_ | 1828901942040985600 |
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| author | David Walter Saskia Hoffmann Eirini-Stavroula Komseli Juri Rappsilber Vassilis Gorgoulis Claus Storgaard Sørensen |
| author_facet | David Walter Saskia Hoffmann Eirini-Stavroula Komseli Juri Rappsilber Vassilis Gorgoulis Claus Storgaard Sørensen |
| author_sort | David Walter |
| collection | DOAJ |
| description | To ensure genome stability, cells need to restrict DNA replication to once per cell cycle. Here the authors show that Cyclin F interacts with and targets the licensing factor CDC6 for degradation, preventing re-firing of replication origins. |
| first_indexed | 2024-12-13T16:07:25Z |
| format | Article |
| id | doaj.art-ea2c7f82640b4cec8dd591558f03042e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:07:25Z |
| publishDate | 2016-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ea2c7f82640b4cec8dd591558f03042e2022-12-21T23:39:01ZengNature PortfolioNature Communications2041-17232016-01-017111010.1038/ncomms10530SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replicationDavid Walter0Saskia Hoffmann1Eirini-Stavroula Komseli2Juri Rappsilber3Vassilis Gorgoulis4Claus Storgaard Sørensen5Biotech Research and Innovation Centre (BRIC), University of CopenhagenBiotech Research and Innovation Centre (BRIC), University of CopenhagenDepartment of Histology and Embryology, School of Medicine, University of AthensWellcome Trust Centre for Cell Biology, University of EdinburghDepartment of Histology and Embryology, School of Medicine, University of AthensBiotech Research and Innovation Centre (BRIC), University of CopenhagenTo ensure genome stability, cells need to restrict DNA replication to once per cell cycle. Here the authors show that Cyclin F interacts with and targets the licensing factor CDC6 for degradation, preventing re-firing of replication origins.https://doi.org/10.1038/ncomms10530 |
| spellingShingle | David Walter Saskia Hoffmann Eirini-Stavroula Komseli Juri Rappsilber Vassilis Gorgoulis Claus Storgaard Sørensen SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication Nature Communications |
| title | SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication |
| title_full | SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication |
| title_fullStr | SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication |
| title_full_unstemmed | SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication |
| title_short | SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication |
| title_sort | scfcyclin f dependent degradation of cdc6 suppresses dna re replication |
| url | https://doi.org/10.1038/ncomms10530 |
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