Increasing the Level of IRS-1 and Insulin Pathway Sensitivity by Natural Product Carainterol A
Carainterol A is a eudesmane sesquiterpenoid extracted from Caragana intermedia. We have reported that carainterol A showed potent glucose consumption activity in C2C12 muscle cells and the db/db mouse model. However, the mechanism of the hypoglycemic effect of carainterol A remains elusive. In this...
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| Format: | Article |
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MDPI AG
2016-09-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/21/10/1303 |
| _version_ | 1818191773854334976 |
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| author | Kaiqing Ma Yanhong Miao Yao Gao Junsheng Tian Li Gao Deyong Ye Xuemei Qin |
| author_facet | Kaiqing Ma Yanhong Miao Yao Gao Junsheng Tian Li Gao Deyong Ye Xuemei Qin |
| author_sort | Kaiqing Ma |
| collection | DOAJ |
| description | Carainterol A is a eudesmane sesquiterpenoid extracted from Caragana intermedia. We have reported that carainterol A showed potent glucose consumption activity in C2C12 muscle cells and the db/db mouse model. However, the mechanism of the hypoglycemic effect of carainterol A remains elusive. In this article, we present a network pharmacology approach to predict the target and signaling pathway of carainterol A which was subsequently validated in HepG2 cells. It was demonstrated that carainterol A could increase the protein levels of IRS-1 and the downstream protein kinase AKT phosphorylation at a low micromolar level. These findings suggest that carainterol A can be a valuable lead compound and a promising chemical probe for the insulin signaling pathway. |
| first_indexed | 2024-12-12T00:19:57Z |
| format | Article |
| id | doaj.art-ea2ec303df604d929a0c6d394f13efac |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-12T00:19:57Z |
| publishDate | 2016-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ea2ec303df604d929a0c6d394f13efac2022-12-22T00:44:46ZengMDPI AGMolecules1420-30492016-09-012110130310.3390/molecules21101303molecules21101303Increasing the Level of IRS-1 and Insulin Pathway Sensitivity by Natural Product Carainterol AKaiqing Ma0Yanhong Miao1Yao Gao2Junsheng Tian3Li Gao4Deyong Ye5Xuemei Qin6Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, ChinaModern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, ChinaModern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, ChinaModern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, ChinaModern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, ChinaDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, ChinaModern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, ChinaCarainterol A is a eudesmane sesquiterpenoid extracted from Caragana intermedia. We have reported that carainterol A showed potent glucose consumption activity in C2C12 muscle cells and the db/db mouse model. However, the mechanism of the hypoglycemic effect of carainterol A remains elusive. In this article, we present a network pharmacology approach to predict the target and signaling pathway of carainterol A which was subsequently validated in HepG2 cells. It was demonstrated that carainterol A could increase the protein levels of IRS-1 and the downstream protein kinase AKT phosphorylation at a low micromolar level. These findings suggest that carainterol A can be a valuable lead compound and a promising chemical probe for the insulin signaling pathway.http://www.mdpi.com/1420-3049/21/10/1303carainterol Anetwork pharmacologyinsulin receptor substrate 1insulin signaling pathway |
| spellingShingle | Kaiqing Ma Yanhong Miao Yao Gao Junsheng Tian Li Gao Deyong Ye Xuemei Qin Increasing the Level of IRS-1 and Insulin Pathway Sensitivity by Natural Product Carainterol A Molecules carainterol A network pharmacology insulin receptor substrate 1 insulin signaling pathway |
| title | Increasing the Level of IRS-1 and Insulin Pathway Sensitivity by Natural Product Carainterol A |
| title_full | Increasing the Level of IRS-1 and Insulin Pathway Sensitivity by Natural Product Carainterol A |
| title_fullStr | Increasing the Level of IRS-1 and Insulin Pathway Sensitivity by Natural Product Carainterol A |
| title_full_unstemmed | Increasing the Level of IRS-1 and Insulin Pathway Sensitivity by Natural Product Carainterol A |
| title_short | Increasing the Level of IRS-1 and Insulin Pathway Sensitivity by Natural Product Carainterol A |
| title_sort | increasing the level of irs 1 and insulin pathway sensitivity by natural product carainterol a |
| topic | carainterol A network pharmacology insulin receptor substrate 1 insulin signaling pathway |
| url | http://www.mdpi.com/1420-3049/21/10/1303 |
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