The relation between serum levels of interleukin 10 and interferon-gamma with oral candidiasis in type 2 diabetes mellitus patients
Abstract Background Type 2 Diabetes mellitus (T2DM) is one of the most common endocrine diseases that weakens the immune system. Candida albicans, is part of the natural oral flora and increases in cases of compromised immune systems. The exact cause of the increased prevalence of candidiasis in pat...
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-022-01217-x |
| _version_ | 1797985514405494784 |
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| author | Atefe Halimi Nazanin Mortazavi Ali Memarian Maryam Zahedi Farhad Niknejad Ahmad Sohrabi Shakiba Javadian Sarraf |
| author_facet | Atefe Halimi Nazanin Mortazavi Ali Memarian Maryam Zahedi Farhad Niknejad Ahmad Sohrabi Shakiba Javadian Sarraf |
| author_sort | Atefe Halimi |
| collection | DOAJ |
| description | Abstract Background Type 2 Diabetes mellitus (T2DM) is one of the most common endocrine diseases that weakens the immune system. Candida albicans, is part of the natural oral flora and increases in cases of compromised immune systems. The exact cause of the increased prevalence of candidiasis in patients with T2DM is still unclear. The study aimed to correlate serum interleukin 10 (IL-10) and interferon-gamma cytokines (IFN-γ) with oral candidiasis in T2DM. Methods In this case–control study, 81 patients with T2DM and 41 non-diabetic individuals aged 30 to 70 years participated. Demographic information, a Blood sample (for blood glucose and cytokine tests), and an oral cotton swab sample from each individual were obtained. The samples were then incubated in a Sabroud dextrose agar medium. Colony growth was calculated and the type of yeast species in individuals with oral candidiasis was identified by culture in CHROMagar Candida medium. IL-10 and IFN-γ were measured by ELISA kit and the data were analyzed using SPSS-18. Results An overall of 122 participants comprised 73.77% females and 26.22% males. An increase in interleukin-10 by 40% and a decrease in IFN-γ by 6% can increase oral candidiasis prevalence among diabetic patients. Candida albicans was the most prevalent Candida species (spp.) in the diabetic and non-diabetic groups. The presence of oral candidiasis was not associated with HbA1c or FBS levels in both groups. Conclusion In the diabetic population, an increase in IL-10 or a decrease in IFN-γ may be associated with an increased risk of oral candidiasis. |
| first_indexed | 2024-04-11T07:19:21Z |
| format | Article |
| id | doaj.art-ea2ff0cf13254c13a05bf392fa6da8d1 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-04-11T07:19:21Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-ea2ff0cf13254c13a05bf392fa6da8d12022-12-22T04:37:49ZengBMCBMC Endocrine Disorders1472-68232022-11-012211610.1186/s12902-022-01217-xThe relation between serum levels of interleukin 10 and interferon-gamma with oral candidiasis in type 2 diabetes mellitus patientsAtefe Halimi0Nazanin Mortazavi1Ali Memarian2Maryam Zahedi3Farhad Niknejad4Ahmad Sohrabi5Shakiba Javadian Sarraf6Dental Research Center, Golestan University of Medical SciencesDental Research Center, Golestan University of Medical SciencesStem Cell Research Center, Golestan University of Medical SciencesDepartment of Internal Medicine, Endocrinology and Metabolic Disorders, Clinical Research Development Unit (CRDU), Sayad Shirazi Hospital, Golestan University of Medical SciencesLaboratory Sciences Research Center, Golestan University of Medical SciencesCancer Control Research Center, Cancer Control Foundation, Iran University of Medical SciencesDental Research Center, Golestan University of Medical SciencesAbstract Background Type 2 Diabetes mellitus (T2DM) is one of the most common endocrine diseases that weakens the immune system. Candida albicans, is part of the natural oral flora and increases in cases of compromised immune systems. The exact cause of the increased prevalence of candidiasis in patients with T2DM is still unclear. The study aimed to correlate serum interleukin 10 (IL-10) and interferon-gamma cytokines (IFN-γ) with oral candidiasis in T2DM. Methods In this case–control study, 81 patients with T2DM and 41 non-diabetic individuals aged 30 to 70 years participated. Demographic information, a Blood sample (for blood glucose and cytokine tests), and an oral cotton swab sample from each individual were obtained. The samples were then incubated in a Sabroud dextrose agar medium. Colony growth was calculated and the type of yeast species in individuals with oral candidiasis was identified by culture in CHROMagar Candida medium. IL-10 and IFN-γ were measured by ELISA kit and the data were analyzed using SPSS-18. Results An overall of 122 participants comprised 73.77% females and 26.22% males. An increase in interleukin-10 by 40% and a decrease in IFN-γ by 6% can increase oral candidiasis prevalence among diabetic patients. Candida albicans was the most prevalent Candida species (spp.) in the diabetic and non-diabetic groups. The presence of oral candidiasis was not associated with HbA1c or FBS levels in both groups. Conclusion In the diabetic population, an increase in IL-10 or a decrease in IFN-γ may be associated with an increased risk of oral candidiasis.https://doi.org/10.1186/s12902-022-01217-xInterferon-gammaInterleukin-10Oral candidiasisType 2 Diabetes Mellitus |
| spellingShingle | Atefe Halimi Nazanin Mortazavi Ali Memarian Maryam Zahedi Farhad Niknejad Ahmad Sohrabi Shakiba Javadian Sarraf The relation between serum levels of interleukin 10 and interferon-gamma with oral candidiasis in type 2 diabetes mellitus patients BMC Endocrine Disorders Interferon-gamma Interleukin-10 Oral candidiasis Type 2 Diabetes Mellitus |
| title | The relation between serum levels of interleukin 10 and interferon-gamma with oral candidiasis in type 2 diabetes mellitus patients |
| title_full | The relation between serum levels of interleukin 10 and interferon-gamma with oral candidiasis in type 2 diabetes mellitus patients |
| title_fullStr | The relation between serum levels of interleukin 10 and interferon-gamma with oral candidiasis in type 2 diabetes mellitus patients |
| title_full_unstemmed | The relation between serum levels of interleukin 10 and interferon-gamma with oral candidiasis in type 2 diabetes mellitus patients |
| title_short | The relation between serum levels of interleukin 10 and interferon-gamma with oral candidiasis in type 2 diabetes mellitus patients |
| title_sort | relation between serum levels of interleukin 10 and interferon gamma with oral candidiasis in type 2 diabetes mellitus patients |
| topic | Interferon-gamma Interleukin-10 Oral candidiasis Type 2 Diabetes Mellitus |
| url | https://doi.org/10.1186/s12902-022-01217-x |
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