Numerical analysis of the effect of trabeculae carneae models on blood flow in a left ventricle model constructed from magnetic resonance images

Although the blood flow velocity in a left ventricle (LV) has been considered to be sufficiently fast to prevent thrombus formation, internal wall structures, such as trabeculae carneae (TC) and papillary muscle, recently received attention as possible causes of reduced near-wall blood flow. As a fu...

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Main Authors: Tomomi YAMADA, Toshiyuki HAYASE, Suguru MIYAUCHI, Kenichi FUNAMOTO
Format: Article
Language:English
Published: The Japan Society of Mechanical Engineers 2018-04-01
Series:Journal of Biomechanical Science and Engineering
Subjects:
Online Access:https://www.jstage.jst.go.jp/article/jbse/13/2/13_17-00597/_pdf/-char/en
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author Tomomi YAMADA
Toshiyuki HAYASE
Suguru MIYAUCHI
Kenichi FUNAMOTO
author_facet Tomomi YAMADA
Toshiyuki HAYASE
Suguru MIYAUCHI
Kenichi FUNAMOTO
author_sort Tomomi YAMADA
collection DOAJ
description Although the blood flow velocity in a left ventricle (LV) has been considered to be sufficiently fast to prevent thrombus formation, internal wall structures, such as trabeculae carneae (TC) and papillary muscle, recently received attention as possible causes of reduced near-wall blood flow. As a fundamental consideration of this problem, this study established a method for constructing an unsteady LV model from magnetic resonance (MR) images and investigated the effect of a few simplified TC structures on the blood flow in the model. The LV model at arbitrary time steps was constructed by deforming a computational mesh generated from MR images at a reference time step. The validity of the proposed construction scheme was confirmed by comparison with the configuration of an LV model extracted from MR images. Numerical analysis was performed for the unsteady blood flow in LV models with and without two simplified TC structures. The flow field in the model with the internal structure differed from that in the model without the internal structure near the wall, and flow separation caused by the internal structure decreased wall shear stress on the rear of the internal structure. The computational results provide fundamental information for the complex interaction between the internal structures and the blood flow in an LV.
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spelling doaj.art-ea321d7e4b61475989c8c65e84b5928a2022-12-22T00:56:30ZengThe Japan Society of Mechanical EngineersJournal of Biomechanical Science and Engineering1880-98632018-04-0113217-0059717-0059710.1299/jbse.17-00597jbseNumerical analysis of the effect of trabeculae carneae models on blood flow in a left ventricle model constructed from magnetic resonance imagesTomomi YAMADA0Toshiyuki HAYASE1Suguru MIYAUCHI2Kenichi FUNAMOTO3Graduate School of Biomedical Engineering, Tohoku UniversityInstitute of Fluid Science, Tohoku UniversityInstitute of Fluid Science, Tohoku UniversityFrontier Research Institute for Interdisciplinary Sciences, Tohoku UniversityAlthough the blood flow velocity in a left ventricle (LV) has been considered to be sufficiently fast to prevent thrombus formation, internal wall structures, such as trabeculae carneae (TC) and papillary muscle, recently received attention as possible causes of reduced near-wall blood flow. As a fundamental consideration of this problem, this study established a method for constructing an unsteady LV model from magnetic resonance (MR) images and investigated the effect of a few simplified TC structures on the blood flow in the model. The LV model at arbitrary time steps was constructed by deforming a computational mesh generated from MR images at a reference time step. The validity of the proposed construction scheme was confirmed by comparison with the configuration of an LV model extracted from MR images. Numerical analysis was performed for the unsteady blood flow in LV models with and without two simplified TC structures. The flow field in the model with the internal structure differed from that in the model without the internal structure near the wall, and flow separation caused by the internal structure decreased wall shear stress on the rear of the internal structure. The computational results provide fundamental information for the complex interaction between the internal structures and the blood flow in an LV.https://www.jstage.jst.go.jp/article/jbse/13/2/13_17-00597/_pdf/-char/enheart thrombusmagnetic resonance imagingcomputational fluid dynamicstrabeculae carneaewall shear stress
spellingShingle Tomomi YAMADA
Toshiyuki HAYASE
Suguru MIYAUCHI
Kenichi FUNAMOTO
Numerical analysis of the effect of trabeculae carneae models on blood flow in a left ventricle model constructed from magnetic resonance images
Journal of Biomechanical Science and Engineering
heart thrombus
magnetic resonance imaging
computational fluid dynamics
trabeculae carneae
wall shear stress
title Numerical analysis of the effect of trabeculae carneae models on blood flow in a left ventricle model constructed from magnetic resonance images
title_full Numerical analysis of the effect of trabeculae carneae models on blood flow in a left ventricle model constructed from magnetic resonance images
title_fullStr Numerical analysis of the effect of trabeculae carneae models on blood flow in a left ventricle model constructed from magnetic resonance images
title_full_unstemmed Numerical analysis of the effect of trabeculae carneae models on blood flow in a left ventricle model constructed from magnetic resonance images
title_short Numerical analysis of the effect of trabeculae carneae models on blood flow in a left ventricle model constructed from magnetic resonance images
title_sort numerical analysis of the effect of trabeculae carneae models on blood flow in a left ventricle model constructed from magnetic resonance images
topic heart thrombus
magnetic resonance imaging
computational fluid dynamics
trabeculae carneae
wall shear stress
url https://www.jstage.jst.go.jp/article/jbse/13/2/13_17-00597/_pdf/-char/en
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