A C57BL/6J Fancg-KO Mouse Model Generated by CRISPR/Cas9 Partially Captures the Human Phenotype

A C57BL/6J Fancg-KO Mouse Model Generated by CRISPR/Cas9 Partially Captures the Human Phenotype

Fanconi anemia (FA) develops due to a mutation in one of the FANC genes that are involved in the repair of interstrand crosslinks (ICLs). FANCG, a member of the FA core complex, is essential for ICL repair. Previous FANCG-deficient mouse models were generated with drug-based selection cassettes in m...

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Bibliographic Details
Main Authors: Ronak Shah, Paul C. M. van den Berk, Colin E. J. Pritchard, Ji-Ying Song, Maaike Kreft, Bas Pilzecker, Heinz Jacobs
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
fanconi anemia (FA)
FANCG
interstrand crosslink (ICL)
DNA damage response
genetically engineered mouse model (GEMM)
CRISPR/Cas9
Online Access:https://www.mdpi.com/1422-0067/24/13/11129

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