The Role of Botulinum Toxin A in Treatment of Temporomandibular Joint Disorders: A Review
Temporomandibular joint disorders (TMDs) usually present with symptoms and signs such as pain, mandibular movement, dysfunction, or joint sounds. Botulinum toxin type A (BTX-A) is a biologic toxin which inhibits skeletal muscle through hindering the production of acetylcholine in the nerve endings....
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2017-09-01
|
| Series: | Journal of Dentistry |
| Subjects: | |
| Online Access: | http://dentjods.sums.ac.ir/index.php/JDSUMS/article/view/1478/1066 |
| _version_ | 1818208305838817280 |
|---|---|
| author | Rana Ataran Ayla Bahramian Zahra Jamali Vahid Pishahang Homayoon Sadeghi Barzegani Parvin Sarbakhsh Javad Yazdani |
| author_facet | Rana Ataran Ayla Bahramian Zahra Jamali Vahid Pishahang Homayoon Sadeghi Barzegani Parvin Sarbakhsh Javad Yazdani |
| author_sort | Rana Ataran |
| collection | DOAJ |
| description | Temporomandibular joint disorders (TMDs) usually present with symptoms and signs such as pain, mandibular movement, dysfunction, or joint sounds. Botulinum toxin type A (BTX-A) is a biologic toxin which inhibits skeletal muscle through hindering the production of acetylcholine in the nerve endings. This toxin is used for the treatment of hyperactivity of lateral pterygoid muscle and TMD symptoms. This comprehensive review aimed to evaluate the effect of BTX-A injections in the lateral pterygoid muscle on treatment of TMDs symptoms. In this study, online databases including Scopus, Medline, Ebsco, Cochrane, EMBASE, and Google scholar were searched for the keywords “pterygoid muscle” and “Onabotulinumtoxin A”.
Twenty-four articles were eligible to be enrolled in the study. In 4 interventional studies and 20 descriptive studies, BTX-A was used for the treatment of TMDs. The dosage and number of injections were different in each study; however, the injection methods were relatively similar. Regardless of the type, number of injections, and dosage, injection of BTX-A in lateral pterygoid seems effective in reducing the click sound and other TMJ-related muscle disorders such as pain, hyperactivity, and dysfunction. |
| first_indexed | 2024-12-12T04:42:43Z |
| format | Article |
| id | doaj.art-ea3409e9f69740a8bcf1565aeba8f177 |
| institution | Directory Open Access Journal |
| issn | 2345-6485 2345-6418 |
| language | English |
| last_indexed | 2024-12-12T04:42:43Z |
| publishDate | 2017-09-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Journal of Dentistry |
| spelling | doaj.art-ea3409e9f69740a8bcf1565aeba8f1772022-12-22T00:37:44ZengShiraz University of Medical SciencesJournal of Dentistry2345-64852345-64182017-09-01183157164The Role of Botulinum Toxin A in Treatment of Temporomandibular Joint Disorders: A ReviewRana Ataran 0Ayla Bahramian 1Zahra Jamali 2Vahid Pishahang 3Homayoon Sadeghi Barzegani 4Parvin Sarbakhsh5Javad Yazdani 6Dept. of Oral Medicine, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.Dept. of Oral Medicine, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.Dept. of Oral Medicine, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.Postgraduate Student, Dept. of Orthodontics, Islamic Azad University of Tehran, Tehran, Iran.Injury Epidemiology and Prevention Researcher, Dept. of Statistics and Epidemiology, Tabriz University of Medical Sciences, Tabriz, Iran.Dept. of Statistics and Epidemiology, Tabriz University of Medical Sciences, Tabriz, Iran.Dept. of Maxillofacial Surgery, Tabriz University of Medical Sciences, Tabriz, Iran.Temporomandibular joint disorders (TMDs) usually present with symptoms and signs such as pain, mandibular movement, dysfunction, or joint sounds. Botulinum toxin type A (BTX-A) is a biologic toxin which inhibits skeletal muscle through hindering the production of acetylcholine in the nerve endings. This toxin is used for the treatment of hyperactivity of lateral pterygoid muscle and TMD symptoms. This comprehensive review aimed to evaluate the effect of BTX-A injections in the lateral pterygoid muscle on treatment of TMDs symptoms. In this study, online databases including Scopus, Medline, Ebsco, Cochrane, EMBASE, and Google scholar were searched for the keywords “pterygoid muscle” and “Onabotulinumtoxin A”. Twenty-four articles were eligible to be enrolled in the study. In 4 interventional studies and 20 descriptive studies, BTX-A was used for the treatment of TMDs. The dosage and number of injections were different in each study; however, the injection methods were relatively similar. Regardless of the type, number of injections, and dosage, injection of BTX-A in lateral pterygoid seems effective in reducing the click sound and other TMJ-related muscle disorders such as pain, hyperactivity, and dysfunction.http://dentjods.sums.ac.ir/index.php/JDSUMS/article/view/1478/1066●Temporomandibular Joint ● Pterygoid Muscles ● Botulinum Toxin |
| spellingShingle | Rana Ataran Ayla Bahramian Zahra Jamali Vahid Pishahang Homayoon Sadeghi Barzegani Parvin Sarbakhsh Javad Yazdani The Role of Botulinum Toxin A in Treatment of Temporomandibular Joint Disorders: A Review Journal of Dentistry ●Temporomandibular Joint ● Pterygoid Muscles ● Botulinum Toxin |
| title | The Role of Botulinum Toxin A in Treatment of Temporomandibular Joint Disorders: A Review |
| title_full | The Role of Botulinum Toxin A in Treatment of Temporomandibular Joint Disorders: A Review |
| title_fullStr | The Role of Botulinum Toxin A in Treatment of Temporomandibular Joint Disorders: A Review |
| title_full_unstemmed | The Role of Botulinum Toxin A in Treatment of Temporomandibular Joint Disorders: A Review |
| title_short | The Role of Botulinum Toxin A in Treatment of Temporomandibular Joint Disorders: A Review |
| title_sort | role of botulinum toxin a in treatment of temporomandibular joint disorders a review |
| topic | ●Temporomandibular Joint ● Pterygoid Muscles ● Botulinum Toxin |
| url | http://dentjods.sums.ac.ir/index.php/JDSUMS/article/view/1478/1066 |
| work_keys_str_mv | AT ranaataran theroleofbotulinumtoxinaintreatmentoftemporomandibularjointdisordersareview AT aylabahramian theroleofbotulinumtoxinaintreatmentoftemporomandibularjointdisordersareview AT zahrajamali theroleofbotulinumtoxinaintreatmentoftemporomandibularjointdisordersareview AT vahidpishahang theroleofbotulinumtoxinaintreatmentoftemporomandibularjointdisordersareview AT homayoonsadeghibarzegani theroleofbotulinumtoxinaintreatmentoftemporomandibularjointdisordersareview AT parvinsarbakhsh theroleofbotulinumtoxinaintreatmentoftemporomandibularjointdisordersareview AT javadyazdani theroleofbotulinumtoxinaintreatmentoftemporomandibularjointdisordersareview AT ranaataran roleofbotulinumtoxinaintreatmentoftemporomandibularjointdisordersareview AT aylabahramian roleofbotulinumtoxinaintreatmentoftemporomandibularjointdisordersareview AT zahrajamali roleofbotulinumtoxinaintreatmentoftemporomandibularjointdisordersareview AT vahidpishahang roleofbotulinumtoxinaintreatmentoftemporomandibularjointdisordersareview AT homayoonsadeghibarzegani roleofbotulinumtoxinaintreatmentoftemporomandibularjointdisordersareview AT parvinsarbakhsh roleofbotulinumtoxinaintreatmentoftemporomandibularjointdisordersareview AT javadyazdani roleofbotulinumtoxinaintreatmentoftemporomandibularjointdisordersareview |