The rectum, anal sphincter and puborectalis muscle show different contraction wave forms during prolonged measurement with a simulated feces
Abstract Contractile patterns in rectum, puborectalis muscle and anal sphincter must be studied to understand defecation. Six subjects had contractile waveforms studied with Fecobionics. Symptom questionnaires, balloon expulsion test and anorectal manometry were done for reference. The Fecobionics b...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-50655-7 |
| _version_ | 1827388581277073408 |
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| author | Daming Sun Kar Man Lo Ssu-Chi Chen Wing Wa Leung Cherry Wong Tony Mak Simon Ng Kaori Futaba Hans Gregersen |
| author_facet | Daming Sun Kar Man Lo Ssu-Chi Chen Wing Wa Leung Cherry Wong Tony Mak Simon Ng Kaori Futaba Hans Gregersen |
| author_sort | Daming Sun |
| collection | DOAJ |
| description | Abstract Contractile patterns in rectum, puborectalis muscle and anal sphincter must be studied to understand defecation. Six subjects had contractile waveforms studied with Fecobionics. Symptom questionnaires, balloon expulsion test and anorectal manometry were done for reference. The Fecobionics bag was filled in rectum to urge-to-defecate volume and measurements were done for 4 h before the subjects attempted to evacuate the device. Pressures and bend angle (BA) variations were analyzed with Fast Fourier Transformation. Four normal subjects exhibited low frequency waves (< 0.06 Hz) for pressures and BA. The waves were uncoordinated between recordings, except for rear and bag pressures. Peak wave amplitudes occurred at 0.02–0.04 Hz. Pressures and the BA differed for peak 1 (p < 0.001) and peak 2 amplitudes (p < 0.005). The front pressure amplitude was bigger than the others (rear and BA, p < 0.05; bag, p < 0.005) for peak 1, and bigger than bag pressure (p < 0.005) and BA (p < 0.05) for peak 2. One subject was considered constipated with lower front pressure amplitudes compared to normal subjects and increased amplitudes for other parameters. The sixth subject was hyperreactive and differed from the other subjects. In conclusion, the rectum, anal sphincter and puborectalis muscle showed different contraction waves during prolonged measurements. The data call for larger studies to better understand normal defecation, feces-withholding patterns, and the implications on anorectal disorders. |
| first_indexed | 2024-03-08T16:20:55Z |
| format | Article |
| id | doaj.art-ea34cd381345486dadbcbb70525efca7 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T16:20:55Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ea34cd381345486dadbcbb70525efca72024-01-07T12:23:49ZengNature PortfolioScientific Reports2045-23222024-01-0114111110.1038/s41598-023-50655-7The rectum, anal sphincter and puborectalis muscle show different contraction wave forms during prolonged measurement with a simulated fecesDaming Sun0Kar Man Lo1Ssu-Chi Chen2Wing Wa Leung3Cherry Wong4Tony Mak5Simon Ng6Kaori Futaba7Hans Gregersen8Chongqing Engineering Research Center of Medical Electronics and Information Technology, Chongqing University of Posts and TelecommunicationsCalifornia Medical Innovations InstituteDepartment of Surgery, The Chinese University of Hong KongDepartment of Surgery, The Chinese University of Hong KongDepartment of Surgery, The Chinese University of Hong KongDepartment of Surgery, The Chinese University of Hong KongDepartment of Surgery, The Chinese University of Hong KongDepartment of Surgery, The Chinese University of Hong KongCalifornia Medical Innovations InstituteAbstract Contractile patterns in rectum, puborectalis muscle and anal sphincter must be studied to understand defecation. Six subjects had contractile waveforms studied with Fecobionics. Symptom questionnaires, balloon expulsion test and anorectal manometry were done for reference. The Fecobionics bag was filled in rectum to urge-to-defecate volume and measurements were done for 4 h before the subjects attempted to evacuate the device. Pressures and bend angle (BA) variations were analyzed with Fast Fourier Transformation. Four normal subjects exhibited low frequency waves (< 0.06 Hz) for pressures and BA. The waves were uncoordinated between recordings, except for rear and bag pressures. Peak wave amplitudes occurred at 0.02–0.04 Hz. Pressures and the BA differed for peak 1 (p < 0.001) and peak 2 amplitudes (p < 0.005). The front pressure amplitude was bigger than the others (rear and BA, p < 0.05; bag, p < 0.005) for peak 1, and bigger than bag pressure (p < 0.005) and BA (p < 0.05) for peak 2. One subject was considered constipated with lower front pressure amplitudes compared to normal subjects and increased amplitudes for other parameters. The sixth subject was hyperreactive and differed from the other subjects. In conclusion, the rectum, anal sphincter and puborectalis muscle showed different contraction waves during prolonged measurements. The data call for larger studies to better understand normal defecation, feces-withholding patterns, and the implications on anorectal disorders.https://doi.org/10.1038/s41598-023-50655-7 |
| spellingShingle | Daming Sun Kar Man Lo Ssu-Chi Chen Wing Wa Leung Cherry Wong Tony Mak Simon Ng Kaori Futaba Hans Gregersen The rectum, anal sphincter and puborectalis muscle show different contraction wave forms during prolonged measurement with a simulated feces Scientific Reports |
| title | The rectum, anal sphincter and puborectalis muscle show different contraction wave forms during prolonged measurement with a simulated feces |
| title_full | The rectum, anal sphincter and puborectalis muscle show different contraction wave forms during prolonged measurement with a simulated feces |
| title_fullStr | The rectum, anal sphincter and puborectalis muscle show different contraction wave forms during prolonged measurement with a simulated feces |
| title_full_unstemmed | The rectum, anal sphincter and puborectalis muscle show different contraction wave forms during prolonged measurement with a simulated feces |
| title_short | The rectum, anal sphincter and puborectalis muscle show different contraction wave forms during prolonged measurement with a simulated feces |
| title_sort | rectum anal sphincter and puborectalis muscle show different contraction wave forms during prolonged measurement with a simulated feces |
| url | https://doi.org/10.1038/s41598-023-50655-7 |
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