Specific alterations of gut microbiota in patients with membranous nephropathy: A systematic review and meta-analysis
Background: The pathogenesis of idiopathic membranous nephropathy (IMN) has not yet been thoroughly clarified, and gut dysbiosis may be a contributor to IMN. However, the characterization of gut microbiota in patients with IMN remains uncertain.Methods: Cochrane Library, PubMed, China National Knowl...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.909491/full |
| _version_ | 1811192235374411776 |
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| author | Yumeng Zhang Yumeng Zhang Jin Zhao Yunlong Qin Yunlong Qin Yuwei Wang Yuwei Wang Zixian Yu Xiaoxuan Ning Shiren Sun |
| author_facet | Yumeng Zhang Yumeng Zhang Jin Zhao Yunlong Qin Yunlong Qin Yuwei Wang Yuwei Wang Zixian Yu Xiaoxuan Ning Shiren Sun |
| author_sort | Yumeng Zhang |
| collection | DOAJ |
| description | Background: The pathogenesis of idiopathic membranous nephropathy (IMN) has not yet been thoroughly clarified, and gut dysbiosis may be a contributor to IMN. However, the characterization of gut microbiota in patients with IMN remains uncertain.Methods: Cochrane Library, PubMed, China National Knowledge Internet, Web of Science, and Embase were used to search for studies through 18 May 2022. A meta-analysis based on the standardized mean difference (SMD) with 95% confidence interval (CI) was conducted on the alpha diversity index. The between-group comparison of the relative abundance of gut microbiota taxa and the beta diversity were extracted and qualitatively analyzed.Results: Five studies were included involving 290 patients with IMN, 100 healthy controls (HCs), and 129 patients with diabetic kidney disease (DKD). The quantitative combination of alpha diversity indices indicated that although bacterial richness was impaired [ACE, SMD = 0.12, (−0.28, 0.52), p = 0.55, I2 = 0%; Chao1, SMD = −0.34, (−0.62, −0.06), p < 0.05, I2 = 36%], overall diversity was preserved [Shannon, SMD = −0.16, (−0.64, 0.31), p = 0.50, I2 = 53%; Simpson, SMD = 0.27, (−0.08, 0.61), p = 0.13, I2 = 0%]. The beta diversity was significantly varied compared to HCs or DKD patients. Compared to HCs, the abundance of Proteobacteria increased, while that of Firmicutes decreased at the phylum level. Furthermore, the abundance of Lachnospira were depleted, while those of Streptococcus were enriched at the genus level. Proteobacteria and Streptococcus were also increased compared to DKD patients.Conclusions: The expansion of Proteobacteria and depletion of Lachnospira may be critical features of the altered gut microbiota in patients with IMN. This condition may play an important role in the pathogenesis of IMN and could provide bacterial targets for diagnosis and therapy. |
| first_indexed | 2024-04-11T23:49:11Z |
| format | Article |
| id | doaj.art-ea34ea127bfb4019ad56c077bfc5ce6b |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-11T23:49:11Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Physiology |
| spelling | doaj.art-ea34ea127bfb4019ad56c077bfc5ce6b2022-12-22T03:56:34ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-11-011310.3389/fphys.2022.909491909491Specific alterations of gut microbiota in patients with membranous nephropathy: A systematic review and meta-analysisYumeng Zhang0Yumeng Zhang1Jin Zhao2Yunlong Qin3Yunlong Qin4Yuwei Wang5Yuwei Wang6Zixian Yu7Xiaoxuan Ning8Shiren Sun9Department of Postgraduate Student, Xi’an Medical University, Xi’an, ChinaDepartment of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, ChinaDepartment of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, ChinaDepartment of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, ChinaDepartment of Nephrology, 980th Hospital of People’s Liberation Army Joint Logistic Support Force (Bethune International Peace Hospital), Shijiazhuang, Hebei, ChinaDepartment of Postgraduate Student, Xi’an Medical University, Xi’an, ChinaDepartment of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, ChinaDepartment of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, ChinaDepartment of Geriatric, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, ChinaDepartment of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, ChinaBackground: The pathogenesis of idiopathic membranous nephropathy (IMN) has not yet been thoroughly clarified, and gut dysbiosis may be a contributor to IMN. However, the characterization of gut microbiota in patients with IMN remains uncertain.Methods: Cochrane Library, PubMed, China National Knowledge Internet, Web of Science, and Embase were used to search for studies through 18 May 2022. A meta-analysis based on the standardized mean difference (SMD) with 95% confidence interval (CI) was conducted on the alpha diversity index. The between-group comparison of the relative abundance of gut microbiota taxa and the beta diversity were extracted and qualitatively analyzed.Results: Five studies were included involving 290 patients with IMN, 100 healthy controls (HCs), and 129 patients with diabetic kidney disease (DKD). The quantitative combination of alpha diversity indices indicated that although bacterial richness was impaired [ACE, SMD = 0.12, (−0.28, 0.52), p = 0.55, I2 = 0%; Chao1, SMD = −0.34, (−0.62, −0.06), p < 0.05, I2 = 36%], overall diversity was preserved [Shannon, SMD = −0.16, (−0.64, 0.31), p = 0.50, I2 = 53%; Simpson, SMD = 0.27, (−0.08, 0.61), p = 0.13, I2 = 0%]. The beta diversity was significantly varied compared to HCs or DKD patients. Compared to HCs, the abundance of Proteobacteria increased, while that of Firmicutes decreased at the phylum level. Furthermore, the abundance of Lachnospira were depleted, while those of Streptococcus were enriched at the genus level. Proteobacteria and Streptococcus were also increased compared to DKD patients.Conclusions: The expansion of Proteobacteria and depletion of Lachnospira may be critical features of the altered gut microbiota in patients with IMN. This condition may play an important role in the pathogenesis of IMN and could provide bacterial targets for diagnosis and therapy.https://www.frontiersin.org/articles/10.3389/fphys.2022.909491/fullgut microbiotamembranous nephropathykidney diseasemeta-analysissystematic review |
| spellingShingle | Yumeng Zhang Yumeng Zhang Jin Zhao Yunlong Qin Yunlong Qin Yuwei Wang Yuwei Wang Zixian Yu Xiaoxuan Ning Shiren Sun Specific alterations of gut microbiota in patients with membranous nephropathy: A systematic review and meta-analysis Frontiers in Physiology gut microbiota membranous nephropathy kidney disease meta-analysis systematic review |
| title | Specific alterations of gut microbiota in patients with membranous nephropathy: A systematic review and meta-analysis |
| title_full | Specific alterations of gut microbiota in patients with membranous nephropathy: A systematic review and meta-analysis |
| title_fullStr | Specific alterations of gut microbiota in patients with membranous nephropathy: A systematic review and meta-analysis |
| title_full_unstemmed | Specific alterations of gut microbiota in patients with membranous nephropathy: A systematic review and meta-analysis |
| title_short | Specific alterations of gut microbiota in patients with membranous nephropathy: A systematic review and meta-analysis |
| title_sort | specific alterations of gut microbiota in patients with membranous nephropathy a systematic review and meta analysis |
| topic | gut microbiota membranous nephropathy kidney disease meta-analysis systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.909491/full |
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