Targeting Inflammasome Activation in Viral Infection: A Therapeutic Solution?
Inflammasome activation is exclusively involved in sensing activation of innate immunity and inflammatory response during viral infection. Accumulating evidence suggests that the manipulation of inflammasome assembly or its interaction with viral proteins are critical factors in viral pathogenesis....
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| Format: | Članak |
| Jezik: | English |
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MDPI AG
2023-06-01
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| Serija: | Viruses |
| Teme: | |
| Online pristup: | https://www.mdpi.com/1999-4915/15/7/1451 |
| _version_ | 1827731625464561664 |
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| author | Chuan-Han Deng Tian-Qi Li Wei Zhang Qi Zhao Ying Wang |
| author_facet | Chuan-Han Deng Tian-Qi Li Wei Zhang Qi Zhao Ying Wang |
| author_sort | Chuan-Han Deng |
| collection | DOAJ |
| description | Inflammasome activation is exclusively involved in sensing activation of innate immunity and inflammatory response during viral infection. Accumulating evidence suggests that the manipulation of inflammasome assembly or its interaction with viral proteins are critical factors in viral pathogenesis. Results from pilot clinical trials show encouraging results of NLRP3 inflammasome suppression in reducing mortality and morbidity in SARS-CoV-2-infected patients. In this article, we summarize the up-to-date understanding of inflammasomes, including NLRP3, AIM2, NLRP1, NLRP6, and NLRC4 in various viral infections, with particular focus on RNA viruses such as SARS-CoV-2, HIV, IAV, and Zika virus and DNA viruses such as herpes simplex virus 1. We also discuss the current achievement of the mechanisms involved in viral infection-induced inflammatory response, host defense, and possible therapeutic solutions. |
| first_indexed | 2024-03-11T00:34:43Z |
| format | Article |
| id | doaj.art-ea352fb9a87d44c4b706273e2c0ad9f8 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T00:34:43Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-ea352fb9a87d44c4b706273e2c0ad9f82023-11-18T21:43:52ZengMDPI AGViruses1999-49152023-06-01157145110.3390/v15071451Targeting Inflammasome Activation in Viral Infection: A Therapeutic Solution?Chuan-Han Deng0Tian-Qi Li1Wei Zhang2Qi Zhao3Ying Wang4State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macao 999078, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macao 999078, ChinaState Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Av. Wai Long, Taipa, Macao 999078, ChinaCancer Centre, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macao 999078, ChinaInflammasome activation is exclusively involved in sensing activation of innate immunity and inflammatory response during viral infection. Accumulating evidence suggests that the manipulation of inflammasome assembly or its interaction with viral proteins are critical factors in viral pathogenesis. Results from pilot clinical trials show encouraging results of NLRP3 inflammasome suppression in reducing mortality and morbidity in SARS-CoV-2-infected patients. In this article, we summarize the up-to-date understanding of inflammasomes, including NLRP3, AIM2, NLRP1, NLRP6, and NLRC4 in various viral infections, with particular focus on RNA viruses such as SARS-CoV-2, HIV, IAV, and Zika virus and DNA viruses such as herpes simplex virus 1. We also discuss the current achievement of the mechanisms involved in viral infection-induced inflammatory response, host defense, and possible therapeutic solutions.https://www.mdpi.com/1999-4915/15/7/1451inflammasomeviral infectioninflammatory responseinnate immunityhost defensetherapy |
| spellingShingle | Chuan-Han Deng Tian-Qi Li Wei Zhang Qi Zhao Ying Wang Targeting Inflammasome Activation in Viral Infection: A Therapeutic Solution? Viruses inflammasome viral infection inflammatory response innate immunity host defense therapy |
| title | Targeting Inflammasome Activation in Viral Infection: A Therapeutic Solution? |
| title_full | Targeting Inflammasome Activation in Viral Infection: A Therapeutic Solution? |
| title_fullStr | Targeting Inflammasome Activation in Viral Infection: A Therapeutic Solution? |
| title_full_unstemmed | Targeting Inflammasome Activation in Viral Infection: A Therapeutic Solution? |
| title_short | Targeting Inflammasome Activation in Viral Infection: A Therapeutic Solution? |
| title_sort | targeting inflammasome activation in viral infection a therapeutic solution |
| topic | inflammasome viral infection inflammatory response innate immunity host defense therapy |
| url | https://www.mdpi.com/1999-4915/15/7/1451 |
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