TRAIL in the Treatment of Cancer: From Soluble Cytokine to Nanosystems
The death ligand tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF cytokine superfamily, has long been recognized for its potential as a cancer therapeutic due to its low toxicity against normal cells. However, its translation into a therapeutic molecule has...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/20/5125 |
| _version_ | 1797474542302527488 |
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| author | Hojjat Alizadeh Zeinabad Eva Szegezdi |
| author_facet | Hojjat Alizadeh Zeinabad Eva Szegezdi |
| author_sort | Hojjat Alizadeh Zeinabad |
| collection | DOAJ |
| description | The death ligand tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF cytokine superfamily, has long been recognized for its potential as a cancer therapeutic due to its low toxicity against normal cells. However, its translation into a therapeutic molecule has not been successful to date, due to its short in vivo half-life associated with insufficient tumor accumulation and resistance of tumor cells to TRAIL-induced killing. Nanotechnology has the capacity to offer solutions to these limitations. This review provides a perspective and a critical assessment of the most promising approaches to realize TRAIL’s potential as an anticancer therapeutic, including the development of fusion constructs, encapsulation, nanoparticle functionalization and tumor-targeting, and discusses the current challenges and future perspectives. |
| first_indexed | 2024-03-09T20:31:35Z |
| format | Article |
| id | doaj.art-ea35f357b93e4f938fc240ad9299b511 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T20:31:35Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ea35f357b93e4f938fc240ad9299b5112023-11-23T23:22:21ZengMDPI AGCancers2072-66942022-10-011420512510.3390/cancers14205125TRAIL in the Treatment of Cancer: From Soluble Cytokine to NanosystemsHojjat Alizadeh Zeinabad0Eva Szegezdi1Apoptosis Research Centre, Biomedical Sciences Building, School of Biological and Chemical Sciences, University of Galway, H91 W2TY Galway, IrelandApoptosis Research Centre, Biomedical Sciences Building, School of Biological and Chemical Sciences, University of Galway, H91 W2TY Galway, IrelandThe death ligand tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF cytokine superfamily, has long been recognized for its potential as a cancer therapeutic due to its low toxicity against normal cells. However, its translation into a therapeutic molecule has not been successful to date, due to its short in vivo half-life associated with insufficient tumor accumulation and resistance of tumor cells to TRAIL-induced killing. Nanotechnology has the capacity to offer solutions to these limitations. This review provides a perspective and a critical assessment of the most promising approaches to realize TRAIL’s potential as an anticancer therapeutic, including the development of fusion constructs, encapsulation, nanoparticle functionalization and tumor-targeting, and discusses the current challenges and future perspectives.https://www.mdpi.com/2072-6694/14/20/5125tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)tumor-targetingdeath receptornanoparticlescancerTRAIL resistance |
| spellingShingle | Hojjat Alizadeh Zeinabad Eva Szegezdi TRAIL in the Treatment of Cancer: From Soluble Cytokine to Nanosystems Cancers tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) tumor-targeting death receptor nanoparticles cancer TRAIL resistance |
| title | TRAIL in the Treatment of Cancer: From Soluble Cytokine to Nanosystems |
| title_full | TRAIL in the Treatment of Cancer: From Soluble Cytokine to Nanosystems |
| title_fullStr | TRAIL in the Treatment of Cancer: From Soluble Cytokine to Nanosystems |
| title_full_unstemmed | TRAIL in the Treatment of Cancer: From Soluble Cytokine to Nanosystems |
| title_short | TRAIL in the Treatment of Cancer: From Soluble Cytokine to Nanosystems |
| title_sort | trail in the treatment of cancer from soluble cytokine to nanosystems |
| topic | tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) tumor-targeting death receptor nanoparticles cancer TRAIL resistance |
| url | https://www.mdpi.com/2072-6694/14/20/5125 |
| work_keys_str_mv | AT hojjatalizadehzeinabad trailinthetreatmentofcancerfromsolublecytokinetonanosystems AT evaszegezdi trailinthetreatmentofcancerfromsolublecytokinetonanosystems |