High level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects
Abstract Fatty liver index (FLI), a predictor of nonalcoholic fatty liver disease, has been reported to be associated with several metabolic disorders. This study aimed to evaluate the relationship between FLI and new onset of diabetes mellitus (DM). We investigated the association of FLI with new o...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-92292-y |
| _version_ | 1828972395781685248 |
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| author | Yukimura Higashiura Masato Furuhashi Marenao Tanaka Satoko Takahashi Masayuki Koyama Hirofumi Ohnishi Keita Numata Takashi Hisasue Nagisa Hanawa Norihito Moniwa Kazufumi Tsuchihashi Tetsuji Miura |
| author_facet | Yukimura Higashiura Masato Furuhashi Marenao Tanaka Satoko Takahashi Masayuki Koyama Hirofumi Ohnishi Keita Numata Takashi Hisasue Nagisa Hanawa Norihito Moniwa Kazufumi Tsuchihashi Tetsuji Miura |
| author_sort | Yukimura Higashiura |
| collection | DOAJ |
| description | Abstract Fatty liver index (FLI), a predictor of nonalcoholic fatty liver disease, has been reported to be associated with several metabolic disorders. This study aimed to evaluate the relationship between FLI and new onset of diabetes mellitus (DM). We investigated the association of FLI with new onset of DM during a 10-year period in subjects who received annual health examinations (n = 28,990). After exclusion of subjects with DM at baseline and those with missing data, a total of 12,290 subjects (male/female: 7925/4365) who received health examinations were recruited. FLI was significantly higher in males than in females. During the 10-year period, DM was developed in 533 males (6.7%) and 128 females (2.9%). Multivariable Cox proportional hazard models with a restricted cubic spline showed that the risk of new onset of DM increased with a higher FLI at baseline in both sexes after adjustment of age, fasting plasma glucose, habits of alcohol drinking and current smoking, family history of DM and diagnosis of hypertension and dyslipidemia at baseline. When the subjects were divided into subgroups according to tertiles of FLI level at baseline (T1–T3) in the absence and presence of impaired fasting glucose (IFG), hazard ratios after adjustment of the confounders gradually increased from T1 to T3 and from the absence to presence of IFG in both male and female subjects. In conclusion, a high level of FLI predicts new onset of DM in a general population of both male and female individuals. |
| first_indexed | 2024-12-14T13:28:25Z |
| format | Article |
| id | doaj.art-ea37350636cd440d95ff8adf0ba9dfcb |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T13:28:25Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ea37350636cd440d95ff8adf0ba9dfcb2022-12-21T22:59:47ZengNature PortfolioScientific Reports2045-23222021-06-0111111010.1038/s41598-021-92292-yHigh level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjectsYukimura Higashiura0Masato Furuhashi1Marenao Tanaka2Satoko Takahashi3Masayuki Koyama4Hirofumi Ohnishi5Keita Numata6Takashi Hisasue7Nagisa Hanawa8Norihito Moniwa9Kazufumi Tsuchihashi10Tetsuji Miura11Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of MedicineDepartment of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of MedicineDepartment of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of MedicineDepartment of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of MedicineDepartment of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of MedicineDepartment of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of MedicineDepartment of Health Checkup and Promotion, Keijinkai Maruyama ClinicDepartment of Health Checkup and Promotion, Keijinkai Maruyama ClinicDepartment of Health Checkup and Promotion, Keijinkai Maruyama ClinicDepartment of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of MedicineDepartment of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of MedicineDepartment of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of MedicineAbstract Fatty liver index (FLI), a predictor of nonalcoholic fatty liver disease, has been reported to be associated with several metabolic disorders. This study aimed to evaluate the relationship between FLI and new onset of diabetes mellitus (DM). We investigated the association of FLI with new onset of DM during a 10-year period in subjects who received annual health examinations (n = 28,990). After exclusion of subjects with DM at baseline and those with missing data, a total of 12,290 subjects (male/female: 7925/4365) who received health examinations were recruited. FLI was significantly higher in males than in females. During the 10-year period, DM was developed in 533 males (6.7%) and 128 females (2.9%). Multivariable Cox proportional hazard models with a restricted cubic spline showed that the risk of new onset of DM increased with a higher FLI at baseline in both sexes after adjustment of age, fasting plasma glucose, habits of alcohol drinking and current smoking, family history of DM and diagnosis of hypertension and dyslipidemia at baseline. When the subjects were divided into subgroups according to tertiles of FLI level at baseline (T1–T3) in the absence and presence of impaired fasting glucose (IFG), hazard ratios after adjustment of the confounders gradually increased from T1 to T3 and from the absence to presence of IFG in both male and female subjects. In conclusion, a high level of FLI predicts new onset of DM in a general population of both male and female individuals.https://doi.org/10.1038/s41598-021-92292-y |
| spellingShingle | Yukimura Higashiura Masato Furuhashi Marenao Tanaka Satoko Takahashi Masayuki Koyama Hirofumi Ohnishi Keita Numata Takashi Hisasue Nagisa Hanawa Norihito Moniwa Kazufumi Tsuchihashi Tetsuji Miura High level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects Scientific Reports |
| title | High level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects |
| title_full | High level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects |
| title_fullStr | High level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects |
| title_full_unstemmed | High level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects |
| title_short | High level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects |
| title_sort | high level of fatty liver index predicts new onset of diabetes mellitus during a 10 year period in healthy subjects |
| url | https://doi.org/10.1038/s41598-021-92292-y |
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