Impact of Endemic Infections on HIV Susceptibility in Sub-Saharan Africa
Abstract Human immunodeficiency virus (HIV) remains a leading cause of global morbidity with the highest burden in Sub-Saharan Africa (SSA). For reasons that are incompletely understood, the likelihood of HIV transmission is several fold higher in SSA than in higher income countries, and most of the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | Tropical Diseases, Travel Medicine and Vaccines |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40794-019-0097-5 |
| _version_ | 1819052768195772416 |
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| author | Sergey Yegorov Vineet Joag Ronald M. Galiwango Sara V. Good Brenda Okech Rupert Kaul |
| author_facet | Sergey Yegorov Vineet Joag Ronald M. Galiwango Sara V. Good Brenda Okech Rupert Kaul |
| author_sort | Sergey Yegorov |
| collection | DOAJ |
| description | Abstract Human immunodeficiency virus (HIV) remains a leading cause of global morbidity with the highest burden in Sub-Saharan Africa (SSA). For reasons that are incompletely understood, the likelihood of HIV transmission is several fold higher in SSA than in higher income countries, and most of these infections are acquired by young women. Residents of SSA are also exposed to a variety of endemic infections, such as malaria and various helminthiases that could influence mucosal and systemic immunology. Since these immune parameters are important determinants of HIV acquisition and progression, this review explores the possible effects of endemic infections on HIV susceptibility and summarizes current knowledge of the epidemiology and underlying immunological mechanisms by which endemic infections could impact HIV acquisition. A better understanding of the interaction between endemic infections and HIV may enhance HIV prevention programs in SSA. |
| first_indexed | 2024-12-21T12:25:05Z |
| format | Article |
| id | doaj.art-ea39e2b7ba0e4c7285447cec25c7e910 |
| institution | Directory Open Access Journal |
| issn | 2055-0936 |
| language | English |
| last_indexed | 2024-12-21T12:25:05Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Tropical Diseases, Travel Medicine and Vaccines |
| spelling | doaj.art-ea39e2b7ba0e4c7285447cec25c7e9102022-12-21T19:04:12ZengBMCTropical Diseases, Travel Medicine and Vaccines2055-09362019-11-015111810.1186/s40794-019-0097-5Impact of Endemic Infections on HIV Susceptibility in Sub-Saharan AfricaSergey Yegorov0Vineet Joag1Ronald M. Galiwango2Sara V. Good3Brenda Okech4Rupert Kaul5Departments of Immunology and Medicine, University of TorontoDepartment of Microbiology and Immunology, University of MinnesotaDepartments of Immunology and Medicine, University of TorontoGenetics & Genome Biology, The Hospital for Sick Children, Peter Gilgan Centre for Research and LearningUVRI-IAVI HIV Vaccine ProgramDepartments of Immunology and Medicine, University of TorontoAbstract Human immunodeficiency virus (HIV) remains a leading cause of global morbidity with the highest burden in Sub-Saharan Africa (SSA). For reasons that are incompletely understood, the likelihood of HIV transmission is several fold higher in SSA than in higher income countries, and most of these infections are acquired by young women. Residents of SSA are also exposed to a variety of endemic infections, such as malaria and various helminthiases that could influence mucosal and systemic immunology. Since these immune parameters are important determinants of HIV acquisition and progression, this review explores the possible effects of endemic infections on HIV susceptibility and summarizes current knowledge of the epidemiology and underlying immunological mechanisms by which endemic infections could impact HIV acquisition. A better understanding of the interaction between endemic infections and HIV may enhance HIV prevention programs in SSA.https://doi.org/10.1186/s40794-019-0097-5HIV susceptibilityHIV risk factorsSub-Saharan Africaparasitic infectionsmalariahelminthiases |
| spellingShingle | Sergey Yegorov Vineet Joag Ronald M. Galiwango Sara V. Good Brenda Okech Rupert Kaul Impact of Endemic Infections on HIV Susceptibility in Sub-Saharan Africa Tropical Diseases, Travel Medicine and Vaccines HIV susceptibility HIV risk factors Sub-Saharan Africa parasitic infections malaria helminthiases |
| title | Impact of Endemic Infections on HIV Susceptibility in Sub-Saharan Africa |
| title_full | Impact of Endemic Infections on HIV Susceptibility in Sub-Saharan Africa |
| title_fullStr | Impact of Endemic Infections on HIV Susceptibility in Sub-Saharan Africa |
| title_full_unstemmed | Impact of Endemic Infections on HIV Susceptibility in Sub-Saharan Africa |
| title_short | Impact of Endemic Infections on HIV Susceptibility in Sub-Saharan Africa |
| title_sort | impact of endemic infections on hiv susceptibility in sub saharan africa |
| topic | HIV susceptibility HIV risk factors Sub-Saharan Africa parasitic infections malaria helminthiases |
| url | https://doi.org/10.1186/s40794-019-0097-5 |
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