Ratiometric delivery of two therapeutic candidates with inherently dissimilar physicochemical property through pH-sensitive core–shell nanoparticles targeting the heterogeneous tumor cells of glioma

Ratiometric delivery of two therapeutic candidates with inherently dissimilar physicochemical property through pH-sensitive core–shell nanoparticles targeting the heterogeneous tumor cells of glioma

Currently, combination drug therapy is one of the most effective approaches to glioma treatment. However, due to the inherent dissimilar pharmacokinetics of individual drugs and blood brain barriers, it was difficult for the concomitant drugs to simultaneously be delivered to glioma in an optimal do...

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Bibliographic Details
Main Authors: He-Lin Xu, Zi-Liang Fan, De-Li ZhuGe, Meng-Qi Tong, Bi-Xin Shen, Meng-Ting Lin, Qun-Yan Zhu, Bing-Hui Jin, Yasin Sohawon, Qing Yao, Ying-Zheng Zhao
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Drug Delivery
Subjects:
ratiometric delivery
dissimilar pharmacokinetics
combination therapy
heterogeneity
targeting
Online Access:http://dx.doi.org/10.1080/10717544.2018.1474974

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