Curcumin Delays Retinal Degeneration by Regulating Microglia Activation in the Retina of rd1 Mice
Background/Aims: Retinitis pigmentosa (RP) is characterized by degeneration of photoreceptors, and there are currently no effective treatments for this disease. However, curcumin has shown neuroprotectant efficacy in a RP rat and swine model, and thus, may have neuroprotective effects in this diseas...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cell Physiol Biochem Press GmbH & Co KG
2017-11-01
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| Series: | Cellular Physiology and Biochemistry |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/485085 |
| _version_ | 1818008176637771776 |
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| author | Yanhe Wang Zhiyuan Yin Lixiong Gao Dayu Sun Xisu Hu Langyue Xue Jiaman Dai YuXiao Zeng Siyu Chen Boju Pan Min Chen Jing Xie Haiwei Xu |
| author_facet | Yanhe Wang Zhiyuan Yin Lixiong Gao Dayu Sun Xisu Hu Langyue Xue Jiaman Dai YuXiao Zeng Siyu Chen Boju Pan Min Chen Jing Xie Haiwei Xu |
| author_sort | Yanhe Wang |
| collection | DOAJ |
| description | Background/Aims: Retinitis pigmentosa (RP) is characterized by degeneration of photoreceptors, and there are currently no effective treatments for this disease. However, curcumin has shown neuroprotectant efficacy in a RP rat and swine model, and thus, may have neuroprotective effects in this disease. Methods: Immunofluorescence staining, electroretinogram recordings, and behavioral tests were used to analyze the effects of curcumin and the underlying mechanism in retinal degeneration 1 (rd1) mice. Results: The number of apoptotic cells in the retina of rd1 mice at postnatal day 14 significantly decreased with curcumin treatment and visual function was improved. The activation of microglia and secretion of chemokines and matrix metalloproteinases in the retina were inhibited by curcumin. These effects were also observed in a co-culture of BV2 microglial cells and retina-derived 661W cells. Conclusions: Curcumin delayed retinal degeneration by suppressing microglia activation in the retina of rd1 mice. Thus, it may be an effective treatment for neurodegenerative disorders such as RP. |
| first_indexed | 2024-04-14T05:25:46Z |
| format | Article |
| id | doaj.art-ea3ad331c3cc4dbc9d5efeb6e77d38dd |
| institution | Directory Open Access Journal |
| issn | 1015-8987 1421-9778 |
| language | English |
| last_indexed | 2024-04-14T05:25:46Z |
| publishDate | 2017-11-01 |
| publisher | Cell Physiol Biochem Press GmbH & Co KG |
| record_format | Article |
| series | Cellular Physiology and Biochemistry |
| spelling | doaj.art-ea3ad331c3cc4dbc9d5efeb6e77d38dd2022-12-22T02:10:00ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782017-11-0144247949310.1159/000485085485085Curcumin Delays Retinal Degeneration by Regulating Microglia Activation in the Retina of rd1 MiceYanhe WangZhiyuan YinLixiong GaoDayu SunXisu HuLangyue XueJiaman DaiYuXiao ZengSiyu ChenBoju PanMin ChenJing XieHaiwei XuBackground/Aims: Retinitis pigmentosa (RP) is characterized by degeneration of photoreceptors, and there are currently no effective treatments for this disease. However, curcumin has shown neuroprotectant efficacy in a RP rat and swine model, and thus, may have neuroprotective effects in this disease. Methods: Immunofluorescence staining, electroretinogram recordings, and behavioral tests were used to analyze the effects of curcumin and the underlying mechanism in retinal degeneration 1 (rd1) mice. Results: The number of apoptotic cells in the retina of rd1 mice at postnatal day 14 significantly decreased with curcumin treatment and visual function was improved. The activation of microglia and secretion of chemokines and matrix metalloproteinases in the retina were inhibited by curcumin. These effects were also observed in a co-culture of BV2 microglial cells and retina-derived 661W cells. Conclusions: Curcumin delayed retinal degeneration by suppressing microglia activation in the retina of rd1 mice. Thus, it may be an effective treatment for neurodegenerative disorders such as RP.https://www.karger.com/Article/FullText/485085Retinitis pigmentosaCurcuminMicrogliard1 miceVisual function |
| spellingShingle | Yanhe Wang Zhiyuan Yin Lixiong Gao Dayu Sun Xisu Hu Langyue Xue Jiaman Dai YuXiao Zeng Siyu Chen Boju Pan Min Chen Jing Xie Haiwei Xu Curcumin Delays Retinal Degeneration by Regulating Microglia Activation in the Retina of rd1 Mice Cellular Physiology and Biochemistry Retinitis pigmentosa Curcumin Microglia rd1 mice Visual function |
| title | Curcumin Delays Retinal Degeneration by Regulating Microglia Activation in the Retina of rd1 Mice |
| title_full | Curcumin Delays Retinal Degeneration by Regulating Microglia Activation in the Retina of rd1 Mice |
| title_fullStr | Curcumin Delays Retinal Degeneration by Regulating Microglia Activation in the Retina of rd1 Mice |
| title_full_unstemmed | Curcumin Delays Retinal Degeneration by Regulating Microglia Activation in the Retina of rd1 Mice |
| title_short | Curcumin Delays Retinal Degeneration by Regulating Microglia Activation in the Retina of rd1 Mice |
| title_sort | curcumin delays retinal degeneration by regulating microglia activation in the retina of rd1 mice |
| topic | Retinitis pigmentosa Curcumin Microglia rd1 mice Visual function |
| url | https://www.karger.com/Article/FullText/485085 |
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