Assessment of Serum Copper, Ceruloplasmin, Copper:Ceruloplasmin ratio in Pregnant women in and around of Warangal
Background: Copper is an essential micronutrient and has an important role in foetal development. Disorders of Copper and Ceruloplasmin levels has been associated with pathological pregnancies.The determination of Copper:Ceruloplasmin ratio has been proposed as one of the better indicator of Co...
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| Format: | Article |
| Language: | English |
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Prathima Institute of Medical Sciences
2017-12-01
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| Series: | Perspectives In Medical Research |
| Subjects: | |
| Online Access: | http://www.pimr.org.in/pullaiah_vol5-issue3-2017.PDF |
| Summary: | Background: Copper is an essential micronutrient and
has an important role in foetal development. Disorders of
Copper and Ceruloplasmin levels has been associated with
pathological pregnancies.The determination of
Copper:Ceruloplasmin ratio has been proposed as one of the
better indicator of Copper status in pregnancy.
Objectives: The present study was undertaken to assess
the Copper status in healthy pregnant women of in and around
warangal comparing with the age matched non-pregnant
women without history of usage of oral contraceptives.
Materials & Methods: The venous samples from twenty
healthy pregnant women aged 20-40yrs in the third trimester
as study group and from twenty healthy non-pregnant women
as control group was taken to compare the levels of Serum
Copper, Ceruloplasmin and Copper:Ceruloplasmin ratio
between groups. Estimation of serum copper was done by End
point colorimetric method, Ceruloplasmin by
Immunoturbidometric assay on Auto analyzer and
Copper:Ceruloplasmin ratio is calculated by formula.
Results: A statistically significant increase(p<0.05) in
serum copper levels of pregnant women (41.64µmol/L ± 6.62)
was noticed when compared with non-pregnant women (21.46
µmol/L ± 3.59). Serum ceruloplasmin levels of pregnant women
(0.43 gm/L ± 0.07) was statistically significant increase
compared with controls (0.21 gm/L ± 0.02) (p<0.05) and a
decrease in Copper:Ceruloplasmin ratio of pregnant women
(12.87 µmol/gm ± 1.51) when compared to control group
(13.22 µmol/gm ± 1.6) was observed, not statistically
significant.
Conclusion: Serum levels of Copper and Ceruloplasmin
were significantly increased in pregnant women and
Copper:Ceruloplasmin ratio decreased but not significant
statistically. |
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| ISSN: | 2348-1447 2348-229X |