Assessment of Serum Copper, Ceruloplasmin, Copper:Ceruloplasmin ratio in Pregnant women in and around of Warangal
Background: Copper is an essential micronutrient and has an important role in foetal development. Disorders of Copper and Ceruloplasmin levels has been associated with pathological pregnancies.The determination of Copper:Ceruloplasmin ratio has been proposed as one of the better indicator of Co...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Prathima Institute of Medical Sciences
2017-12-01
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| Series: | Perspectives In Medical Research |
| Subjects: | |
| Online Access: | http://www.pimr.org.in/pullaiah_vol5-issue3-2017.PDF |
| _version_ | 1797462486288433152 |
|---|---|
| author | Pullaiah Akinepalli 1 , Narender Gaddam 2 |
| author_facet | Pullaiah Akinepalli 1 , Narender Gaddam 2 |
| author_sort | Pullaiah Akinepalli 1 , Narender Gaddam 2 |
| collection | DOAJ |
| description | Background: Copper is an essential micronutrient and
has an important role in foetal development. Disorders of
Copper and Ceruloplasmin levels has been associated with
pathological pregnancies.The determination of
Copper:Ceruloplasmin ratio has been proposed as one of the
better indicator of Copper status in pregnancy.
Objectives: The present study was undertaken to assess
the Copper status in healthy pregnant women of in and around
warangal comparing with the age matched non-pregnant
women without history of usage of oral contraceptives.
Materials & Methods: The venous samples from twenty
healthy pregnant women aged 20-40yrs in the third trimester
as study group and from twenty healthy non-pregnant women
as control group was taken to compare the levels of Serum
Copper, Ceruloplasmin and Copper:Ceruloplasmin ratio
between groups. Estimation of serum copper was done by End
point colorimetric method, Ceruloplasmin by
Immunoturbidometric assay on Auto analyzer and
Copper:Ceruloplasmin ratio is calculated by formula.
Results: A statistically significant increase(p<0.05) in
serum copper levels of pregnant women (41.64µmol/L ± 6.62)
was noticed when compared with non-pregnant women (21.46
µmol/L ± 3.59). Serum ceruloplasmin levels of pregnant women
(0.43 gm/L ± 0.07) was statistically significant increase
compared with controls (0.21 gm/L ± 0.02) (p<0.05) and a
decrease in Copper:Ceruloplasmin ratio of pregnant women
(12.87 µmol/gm ± 1.51) when compared to control group
(13.22 µmol/gm ± 1.6) was observed, not statistically
significant.
Conclusion: Serum levels of Copper and Ceruloplasmin
were significantly increased in pregnant women and
Copper:Ceruloplasmin ratio decreased but not significant
statistically. |
| first_indexed | 2024-03-09T17:37:16Z |
| format | Article |
| id | doaj.art-ea3bda0261134155baa623fc139ebe37 |
| institution | Directory Open Access Journal |
| issn | 2348-1447 2348-229X |
| language | English |
| last_indexed | 2024-03-09T17:37:16Z |
| publishDate | 2017-12-01 |
| publisher | Prathima Institute of Medical Sciences |
| record_format | Article |
| series | Perspectives In Medical Research |
| spelling | doaj.art-ea3bda0261134155baa623fc139ebe372023-11-24T11:52:41ZengPrathima Institute of Medical SciencesPerspectives In Medical Research2348-14472348-229X2017-12-01532932Assessment of Serum Copper, Ceruloplasmin, Copper:Ceruloplasmin ratio in Pregnant women in and around of WarangalPullaiah Akinepalli 1 , Narender Gaddam 20Kakatiya Medical collegeBackground: Copper is an essential micronutrient and has an important role in foetal development. Disorders of Copper and Ceruloplasmin levels has been associated with pathological pregnancies.The determination of Copper:Ceruloplasmin ratio has been proposed as one of the better indicator of Copper status in pregnancy. Objectives: The present study was undertaken to assess the Copper status in healthy pregnant women of in and around warangal comparing with the age matched non-pregnant women without history of usage of oral contraceptives. Materials & Methods: The venous samples from twenty healthy pregnant women aged 20-40yrs in the third trimester as study group and from twenty healthy non-pregnant women as control group was taken to compare the levels of Serum Copper, Ceruloplasmin and Copper:Ceruloplasmin ratio between groups. Estimation of serum copper was done by End point colorimetric method, Ceruloplasmin by Immunoturbidometric assay on Auto analyzer and Copper:Ceruloplasmin ratio is calculated by formula. Results: A statistically significant increase(p<0.05) in serum copper levels of pregnant women (41.64µmol/L ± 6.62) was noticed when compared with non-pregnant women (21.46 µmol/L ± 3.59). Serum ceruloplasmin levels of pregnant women (0.43 gm/L ± 0.07) was statistically significant increase compared with controls (0.21 gm/L ± 0.02) (p<0.05) and a decrease in Copper:Ceruloplasmin ratio of pregnant women (12.87 µmol/gm ± 1.51) when compared to control group (13.22 µmol/gm ± 1.6) was observed, not statistically significant. Conclusion: Serum levels of Copper and Ceruloplasmin were significantly increased in pregnant women and Copper:Ceruloplasmin ratio decreased but not significant statistically.http://www.pimr.org.in/pullaiah_vol5-issue3-2017.PDFcopperceruloplasmincopper: ceruloplasmin ratiopregnancy |
| spellingShingle | Pullaiah Akinepalli 1 , Narender Gaddam 2 Assessment of Serum Copper, Ceruloplasmin, Copper:Ceruloplasmin ratio in Pregnant women in and around of Warangal Perspectives In Medical Research copper ceruloplasmin copper: ceruloplasmin ratio pregnancy |
| title | Assessment of Serum Copper, Ceruloplasmin, Copper:Ceruloplasmin ratio in Pregnant women in and around of Warangal |
| title_full | Assessment of Serum Copper, Ceruloplasmin, Copper:Ceruloplasmin ratio in Pregnant women in and around of Warangal |
| title_fullStr | Assessment of Serum Copper, Ceruloplasmin, Copper:Ceruloplasmin ratio in Pregnant women in and around of Warangal |
| title_full_unstemmed | Assessment of Serum Copper, Ceruloplasmin, Copper:Ceruloplasmin ratio in Pregnant women in and around of Warangal |
| title_short | Assessment of Serum Copper, Ceruloplasmin, Copper:Ceruloplasmin ratio in Pregnant women in and around of Warangal |
| title_sort | assessment of serum copper ceruloplasmin copper ceruloplasmin ratio in pregnant women in and around of warangal |
| topic | copper ceruloplasmin copper: ceruloplasmin ratio pregnancy |
| url | http://www.pimr.org.in/pullaiah_vol5-issue3-2017.PDF |
| work_keys_str_mv | AT pullaiahakinepalli1narendergaddam2 assessmentofserumcopperceruloplasmincopperceruloplasminratioinpregnantwomeninandaroundofwarangal |