Postinfectious Onset of Myasthenia Gravis in a COVID-19 Patient
Objective: We report the case of a young woman with postinfectious onset of myasthenia gravis after COVID-19 with mild respiratory symptoms and anosmia/ageusia 1 month before admission to our neurological department.Methods: Patient data were derived from medical records of Hannover Medical School,...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-10-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.576153/full |
| _version_ | 1818880428149309440 |
|---|---|
| author | Meret Huber Sophia Rogozinski Wolfram Puppe Carsten Framme Günter Höglinger Karsten Hufendiek Florian Wegner |
| author_facet | Meret Huber Sophia Rogozinski Wolfram Puppe Carsten Framme Günter Höglinger Karsten Hufendiek Florian Wegner |
| author_sort | Meret Huber |
| collection | DOAJ |
| description | Objective: We report the case of a young woman with postinfectious onset of myasthenia gravis after COVID-19 with mild respiratory symptoms and anosmia/ageusia 1 month before admission to our neurological department.Methods: Patient data were derived from medical records of Hannover Medical School, Germany. Written informed consent was obtained from the patient.Results: The 21-year-old female patient presented with subacute, vertically shifted double vision evoked by right sided partial oculomotor paresis and ptosis. About 4 weeks earlier she had suffered from mild respiratory symptoms, aching limbs and head without fever, accompanied by anosmia/ageusia. During the persistence of the latter symptoms for around 10 days the patient had already noticed “tired eyes” and fluctuating double vision. Clinical assessment including a positive test with edrophonium chloride and increased acetylcholine receptor antibodies related the ocular manifestation etiologically to myasthenia gravis. Antibodies (IgA/IgG) against SARS-CoV-2 using three different serological tests (Abbott, DiaSorin, Euroimmun) were detected in serum suggesting this specific coronavirus as previously infectious agent in our patient. The myasthenic syndrome was treated successfully with intravenous immunoglobulins and oral pyridostigmine.Conclusion: This is the first case presentation of postinfectious myasthenia gravis as neurological complication in a COVID-19 patient. |
| first_indexed | 2024-12-19T14:45:48Z |
| format | Article |
| id | doaj.art-ea3cdc39f6424f46a10c716f0bf7c1ac |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-19T14:45:48Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-ea3cdc39f6424f46a10c716f0bf7c1ac2022-12-21T20:16:57ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-10-011110.3389/fneur.2020.576153576153Postinfectious Onset of Myasthenia Gravis in a COVID-19 PatientMeret Huber0Sophia Rogozinski1Wolfram Puppe2Carsten Framme3Günter Höglinger4Karsten Hufendiek5Florian Wegner6Department of Neurology, Hannover Medical School, Hanover, GermanyDepartment of Neurology, Hannover Medical School, Hanover, GermanyInstitute of Virology, Hannover Medical School, Hanover, GermanyDepartment of Ophthalmology, Hannover Medical School, Hanover, GermanyDepartment of Neurology, Hannover Medical School, Hanover, GermanyDepartment of Ophthalmology, Hannover Medical School, Hanover, GermanyDepartment of Neurology, Hannover Medical School, Hanover, GermanyObjective: We report the case of a young woman with postinfectious onset of myasthenia gravis after COVID-19 with mild respiratory symptoms and anosmia/ageusia 1 month before admission to our neurological department.Methods: Patient data were derived from medical records of Hannover Medical School, Germany. Written informed consent was obtained from the patient.Results: The 21-year-old female patient presented with subacute, vertically shifted double vision evoked by right sided partial oculomotor paresis and ptosis. About 4 weeks earlier she had suffered from mild respiratory symptoms, aching limbs and head without fever, accompanied by anosmia/ageusia. During the persistence of the latter symptoms for around 10 days the patient had already noticed “tired eyes” and fluctuating double vision. Clinical assessment including a positive test with edrophonium chloride and increased acetylcholine receptor antibodies related the ocular manifestation etiologically to myasthenia gravis. Antibodies (IgA/IgG) against SARS-CoV-2 using three different serological tests (Abbott, DiaSorin, Euroimmun) were detected in serum suggesting this specific coronavirus as previously infectious agent in our patient. The myasthenic syndrome was treated successfully with intravenous immunoglobulins and oral pyridostigmine.Conclusion: This is the first case presentation of postinfectious myasthenia gravis as neurological complication in a COVID-19 patient.https://www.frontiersin.org/article/10.3389/fneur.2020.576153/fullanosmia/ageusiaCOVID-19diplopianeurological manifestationpostinfectious myasthenia gravisSARS-CoV-2 |
| spellingShingle | Meret Huber Sophia Rogozinski Wolfram Puppe Carsten Framme Günter Höglinger Karsten Hufendiek Florian Wegner Postinfectious Onset of Myasthenia Gravis in a COVID-19 Patient Frontiers in Neurology anosmia/ageusia COVID-19 diplopia neurological manifestation postinfectious myasthenia gravis SARS-CoV-2 |
| title | Postinfectious Onset of Myasthenia Gravis in a COVID-19 Patient |
| title_full | Postinfectious Onset of Myasthenia Gravis in a COVID-19 Patient |
| title_fullStr | Postinfectious Onset of Myasthenia Gravis in a COVID-19 Patient |
| title_full_unstemmed | Postinfectious Onset of Myasthenia Gravis in a COVID-19 Patient |
| title_short | Postinfectious Onset of Myasthenia Gravis in a COVID-19 Patient |
| title_sort | postinfectious onset of myasthenia gravis in a covid 19 patient |
| topic | anosmia/ageusia COVID-19 diplopia neurological manifestation postinfectious myasthenia gravis SARS-CoV-2 |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.576153/full |
| work_keys_str_mv | AT merethuber postinfectiousonsetofmyastheniagravisinacovid19patient AT sophiarogozinski postinfectiousonsetofmyastheniagravisinacovid19patient AT wolframpuppe postinfectiousonsetofmyastheniagravisinacovid19patient AT carstenframme postinfectiousonsetofmyastheniagravisinacovid19patient AT gunterhoglinger postinfectiousonsetofmyastheniagravisinacovid19patient AT karstenhufendiek postinfectiousonsetofmyastheniagravisinacovid19patient AT florianwegner postinfectiousonsetofmyastheniagravisinacovid19patient |